A5088904911- Vasculitis and related conditions
- IgG4-Related and Inflammatory Diseases
- Otitis Media and Relapsing Polychondritis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neuroendocrine Tumor Research Advances
- Renal Diseases and Glomerulopathies
- Systemic Lupus Erythematosus Research
- IL-33, ST2, and ILC Pathways
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Inflammasome and immune disorders
- Vascular Malformations and Hemangiomas
- T-cell and B-cell Immunology
- Soft tissue tumor case studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Leptospirosis research and findings
- Cell Adhesion Molecules Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autoimmune and Inflammatory Disorders Research
- Sarcoidosis and Beryllium Toxicity Research
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal disorders and treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Ocular Diseases and Behçet’s Syndrome
- Eosinophilic Disorders and Syndromes
- Musculoskeletal synovial abnormalities and treatments
Kyoto University
2021-2024
Kurashiki Central Hospital
2017-2024
Kitano Hospital
2021
Weatherford College
2020
Horiba (Japan)
2020
Despite the importance of IL-23 in mucosal host defense and disease pathogenesis, mechanisms regulating development IL-23–producing mononuclear phagocytes remain poorly understood. Here, we employed an Il23aVenus reporter strain to investigate developmental identity functional regulation cells. We showed that flagellin stimulation or Citrobacter rodentium infection led robust induction EpCAM+ DCIR2+ CD103− cDC2s, termed cDCIL23, which was confined gut-associated lymphoid tissues, including...
Abstract Recent large observational studies of antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV) show that severe infection is a major cause death and the majority infections occur during early phase initiating remission-induction therapy. Many risk factors for have been suggested, but these inconsistent. Nevertheless, infectious in elderly patients with AAV not adequately investigated previous studies. In this retrospective study, we examined potential predictors within 90...
Pulmonary artery involvement (PAI) in Takayasu arteritis (TAK) can lead to severe complications, but the relationship between two has not been fully clarified.We retrospectively investigated 166 consecutive patients with TAK who attended Kyoto University Hospital from 1997 2018. The demographic data, clinical symptoms and signs, comorbidities, treatments, imaging findings were compared without PAI. was diagnosed based on American College of Rheumatology Classification Criteria (1990) or...
Rationale: Thrombocytepenia, anasarca, fever, renal insufficiency, and organomegaly (TAFRO) syndrome is a novel disease entity characterized by constellation of symptoms (thrombocytopenia, organomegaly). Here, we describe the development TAFRO syndrome-like features during treatment rheumatoid arthritis with Janus kinase (JAK) inhibitor. Patient concerns: In this report, 74-year-old woman treated JAK inhibitor (tofacitinib) for was admitted because fever thrombocytopenia. Diagnoses: On...
Abstract We aimed to investigate the efficacy of plasma exchange on severe anti‐neutrophil cytoplasmic antibody‐associated vasculitis (AAV). Of 182 patients with AAV in our hospital, 12 life‐threatening organ damage (rapidly progressive glomerulonephritis and/or diffuse alveolar hemorrhage) underwent centrifuge‐based therapeutic and immunosuppressive therapy. Twenty‐four matched for age, serum creatinine, severity vasculitis, who received high‐dose glucocorticoids or without...
<h3>Background</h3> Behcet9s disease is a systemic vasculitis with oral and genital aphthous ulcers, ocular involvements, skin manifestations, arthritis, gastrointestinal neurogenic diseases vascular involvements. Patients are known to distribute along the ancient Silk Road, including Japan. <h3>Objectives</h3> We evaluate clinical features of in <h3>Methods</h3> retrospectively investigated 223 patients (108 males 115 females) who fulfilled International Criteria for Disease (ICBD) from...
<h3>Background:</h3> IgG4-related disease (IgG4RD) is a chronic and systemic that characterised by multiple organ inflammation, elevated serum IgG4, storiform fibrosis. IgG4RD often presents with enlargement can affect the submandibular glands, lacrimal orbits, pancreas, bile ducts, retroperitoneum, lungs, kidneys, aorta pachymeninges [1]. One of most commonly involved organs glands. However, methods for evaluating severity treatment response sialadenitis have not been established....
A 55-year-old-man presented with low-grade fever, general fatigue, appetite loss and body weight loss. An electrocardiogram (ECG) showed the presence of long QT syndrome (LQTS), laboratory tests revealed elevated serum immunoglobulin G4 (IgG4) concentration adrenal insufficiency. Imaging studies lymphadenopathy, salivary lacrimal gland enlargement, interstitial pneumonia, multiple bilateral kidney nodules, periaortitis, enlargement pituitary stalk. Histological examination lip infiltration...
Abstract BackgroundPulmonary artery involvement (PAI) in Takayasu arteritis (TAK) can lead to severe complications, but the relationship between two has not been fully clarified.MethodsWe retrospectively investigated 166 consecutive patients with TAK who attended Kyoto University Hospital from 1997 2018. The demographic data, clinical symptoms and signs, comorbidities, treatments, imaging findings were compared without PAI. was diagnosed based on American College of Rheumatology...
ABSTRACT Ig (immunoglobulin) G4-related disease (Ig4-RD) affects several organs, including salivary glands, lacrimal pancreas, biliary ducts, and retroperitoneum. A 72-year-old woman was examined for hypereosinophilia, high levels of IgG4, polyneuropathy, liver dysfunction, enlargement lymph nodes beaded dilation the bile ducts. We diagnosed Ig4-RD based on biopsies nodes, liver, submandibular gland. The symptoms patient improved after glucocorticoid treatment. This a novel atypical case...
<h3>Background</h3> We sometimes experience the cases with fever and muscle pain of lower limbs without any other specific features. There are sporadic case reports eosinophilic fasciitis limb restricted vasculitis. However, few compare discuss such cases. <h3>Objectives</h3> To describe clinical features, MRI findings, histopathology, diagnosis response to treatment these <h3>Methods</h3> retrospectively analyzed features 28 patients who were admitted our hospital because from 2004 2016....
<h3>Background</h3> The introduction of treatment regimens comprising cyclophosphamide or rituximab combined with corticosteroids has brought about dramatic improvements in the prognosis ANCA-associated vasculitis.<sup>1</sup> Severe infectious events, especially early phase treatment, associated risk death have been reported past several studies.<sup>2,3</sup> <h3>Objectives</h3> We retrospectively investigated association between mortality and severe infection patients antineutrophil...
<h3>Background</h3> Colour doppler ultrasonography (CDU) in temporal arteries (TA) is useful for diagnosis and follow-up of giant cell arteritis (GCA).<sup>1</sup> However, the usefulness CDU carotid (CA) GCA not fully understood.<sup> 2</sup> <h3>Objectives</h3> We investigated retrospectively relationship between clinical features vessel wall thickness TA CA on at baseline during follow-up. <h3>Methods</h3> recruited patients with newly diagnosed our hospital from January 2004 to July...
<h3>Background</h3> IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory condition characterized by tumefactive lesions and, often but not always, elevated serum IgG4 levels [1]. Glucocorticoids (GC) are usually used as induction therapy for IgG4-RD. However, relapse occurs following GC tapering, and predictors of remain unclear. <h3>Objectives</h3> To identify IgG4-RD after therapy. <h3>Methods</h3> We retrospectively reviewed 57 patients diagnosed with treated in our hospital...