A5090653722- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Inflammasome and immune disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Parvovirus B19 Infection Studies
- Respiratory Support and Mechanisms
- interferon and immune responses
- Medical Imaging and Pathology Studies
- Systemic Sclerosis and Related Diseases
- Adolescent and Pediatric Healthcare
- Cytomegalovirus and herpesvirus research
- Calcium signaling and nucleotide metabolism
- Medical Imaging Techniques and Applications
- Cardiovascular Syncope and Autonomic Disorders
- Non-Invasive Vital Sign Monitoring
- Heart Rate Variability and Autonomic Control
- IL-33, ST2, and ILC Pathways
- Metabolism and Genetic Disorders
- Pluripotent Stem Cells Research
- Thyroid Cancer Diagnosis and Treatment
- T-cell and B-cell Immunology
- Pancreatic function and diabetes
- Circadian rhythm and melatonin
- Glioma Diagnosis and Treatment
Kyoto University
1998-2024
Gifu University
2017-2024
National Institute of Allergy and Infectious Diseases
2021
Aichi Medical University
2018-2019
Kariya Toyota General Hospital
2015
Yokohama City University
2011-2014
Kitano Hospital
2011-2013
Kyoto University Institute for Chemical Research
1998
Instituto de Investigaciones Químicas
1998
Royal Victoria Hospital
1966
The aim of this study was to determine the usefulness three-lead electrocardiogram (ECG) during neonatal resuscitation.Both pulse oximetry (PO) and ECG were applied immediately after delivery measure heart rate (HR). We reviewed video recordings respective monitors, checked time at which each monitor started display reliable values.In 20 deliveries, showed HR much earlier than PO (median 38 s vs 122 delivery). displayed throughout resuscitation. able confirm effectiveness initial respiratory...
Mutations in the C-terminal region of CDC42 gene cause severe neonatal-onset autoinflammation. Effectiveness IL-1β–blocking therapy indicates that pathology involves abnormal inflammasome activation; however, mechanism underlying autoinflammation remains to be elucidated. Using induced-pluripotent stem cells established from patients carrying CDC42R186C, we found patient-derived secreted larger amounts IL-1β response pyrin-activating stimuli. Aberrant palmitoylation and localization...
For long QT syndrome (LQTS), recent progress in genome-sequencing technologies enabled the identification of rare genomic variants with diagnostic, prognostic, and therapeutic implications. However, pathogenic stratification identified remains challenging, especially uncertain significance. This study aimed to propose a phenotypic cell-based diagnostic assay for identifying LQTS recognize high-throughput manner suitable screening. We investigated response LQT2-induced pluripotent stem cell...
Summary Haemophagocytic lymphohistiocytosis ( HLH ) is a life‐threatening syndrome of immune dysregulation and classified as primary or secondary according to the underlying aetiology. The treatment strategies recommended for these two groups differ substantially; however, it thought be impossible predict causes using conventional laboratory tests. Recent studies show that serum levels soluble interleukin‐2 receptor sIL 2R) ferritin are useful differentiating some forms . present study...
Patients with activated phosphatidylinositol 3-kinase delta (PI3Kδ) syndrome (APDS) present sinopulmonary infections, lymphadenopathy, and cytomegalvirus (CMV) and/or Epstein-Barr virus (EBV) viremia, yet why patients fail to clear certain chronic viral infections remains incompletely understood. Using patient samples a mouse model (Pik3cdE1020K/+ mice), we demonstrate that, upon activation, Pik3cdE1020K/+ CD8+ T cells exhibit exaggerated features of effector populations both in vitro after...
Over the last decade, novel anticancer drugs have improved prognosis for recurrent or metastatic squamous cell carcinoma of head and neck (RM-SCCHN). However, this has increased healthcare expenditures placed a heavy burden on patients society. This study investigated frequency use costs select palliative chemotherapy regimens in Japan.
Purpose: The purpose of the present study was to investigate F-18 FDG uptake patterns, and see whether joint reflected disease activity in patients with collagen vascular diseases (CVD)-associated arthritis. Materials Methods: A total 72 CVD-associated arthritis 30 control subjects who underwent PET or PET/CT were retrospectively investigated. images 12 major joints, 7 minor extra-articular accumulation assessed. We investigated patterns relationships between degree distribution, clinical...
Dried blood spots (DBS) are widely used for screening biomolecular profiles, including enzymatic activities. However, detection of minor proteins in DBS by liquid chromatography–mass spectrometry (LC-MS/MS) without pre-enrichment remains challenging because the coexistence large quantities hydrophilic proteins. In this study, we address problem developing a simple method using sodium carbonate precipitation (SCP). SCP enriches hydrophobic from DBS, allowing substantial removal soluble...
To investigate the mechanism of antioxidative effects sesamin in vivo, 32 male ddY mice were administered with 10 mg/kg or 100 (S10, S100), vitamin E (VE100) control sample (C). They subjected to 30 min swimming exercise 2 h after administration by using a new forced-swimming apparatus, i. e. an adjustable-current pool. Exercise resulted significant increase plasma lipid peroxides (LPO) C and VE100 (p < 0.01), but not S10 S100. S100 showed significantly higher total glutathione peroxidase...
LipB, the lipase activator protein of Pseudomonas aeruginosa TE3285, was overproduced in Escherichia coli, and purified 4.9-fold over crude extract presence SDS. The LipB reactivated from P. TE3285 denatured with guanidine hydrochloride, its reactivation did not involve multiple turnover. In this reactivation, a 1: 1 complex between detected cross-linking experiment, suggesting that still binds to after reactivation. Calcium ion essential for formation addition EDTA caused inactivation bound...
Abstract Purpose This study aimed to evaluate the MRI features of main histological subtypes thyroid cancer and enable differentiation between anaplastic carcinoma (ATC), poorly differentiated (PDTC), papillary (PTC). Materials methods included 79 patients with histopathologically proven (14 ATCs, 8 PDTCs, 57 PTCs) who underwent neck MRI. images were retrospectively reviewed compared three pathologies. Results The maximum diameter was larger in ATCs PDTCs than PTCs (65.2 mm 38.4 vs. 26.0 mm,...
Abstract Dumping syndrome is infrequently reported, but known to occur after N issen fundoplication in children. However, it may be difficult both diagnose and manage. Here we presented four infants who received for severe gastroesophageal reflux disease, two of whom developed dumping whilst the other did not. Continuous glucose monitoring ( CGM ) was very useful clearly detect large glycemic fluctuation around each feeding. also helpful prove effect treatment avoid abnormal levels. We...
Abstract A 5‐year‐old boy with glioblastoma relapsed soon after postoperative irradiation in combination temozolomide. Second‐line chemotherapy was also ineffective; therefore, the bevacizumab and irinotecan were given a third gross‐total resection of tumor. Treatment interrupted for 1 month due to development posterior reversible encephalopathy syndrome, but re‐initiated at lower dose prolonged intervals between treatments. The patient alive disease free 2 years initial diagnosis....
SummaryArterial blood gas tensions, pulse and pressure were monitored repeatedly in 7 normal young men while they breathed 99% oxygen at 3 atmospheres a hyperbaric chamber for periods of up to hours. There was evidence that 6 these subjects hyperventilated during the exposure. Arterial Pco2 began fall first 5 minutes exposure continued decline 35 mm Hg 90 minutes. It tended remain constant rest Po2 rose 2000 remained this level. The rate fell by 25% level least 2 hours when it increase....
This study evaluated the respiratory motion of lung parenchyma using dynamic magnetic resonance imaging and clarified differences between healthy individuals patients with chronic obstructive pulmonary disease (COPD).The comprised 6 volunteers 42 diagnosed smoking-related COPD. We captured 80 sequential frames from mid-sagittal portion right while repeating forced deep breathing a balanced fast-field echo sequence (repetition time, 2.2 ms; 1.1 slice thickness, 10 mm; field view, 450 matrix...
Small cell neuroendocrine carcinoma of the head and neck is a rarely occurring poorly differentiated high-grade malignant neoplasm characterized by highly active proliferation tumor cells. There are no established therapies for this disease. To clarify clinical course develop effective treatment(s) carcinoma, we reviewed data 8 patients small treated us between 2006 2014 at Department Otolaryngology, Gifu University School Medicine our affiliated hospitals. The consisted 3 men 5 women,...