A5101902524- Reproductive tract infections research
- Effects and risks of endocrine disrupting chemicals
- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Carcinogens and Genotoxicity Assessment
- Cervical Cancer and HPV Research
- Parasitic Infections and Diagnostics
- Metabolomics and Mass Spectrometry Studies
- Toxoplasma gondii Research Studies
- Aldose Reductase and Taurine
- Adolescent Sexual and Reproductive Health
- Galectins and Cancer Biology
- Adipokines, Inflammation, and Metabolic Diseases
- Wnt/β-catenin signaling in development and cancer
- Natural product bioactivities and synthesis
- PI3K/AKT/mTOR signaling in cancer
- Pluripotent Stem Cells Research
- Heme Oxygenase-1 and Carbon Monoxide
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemistry and Bioactive Compounds
- Nuclear Receptors and Signaling
- HIV, Drug Use, Sexual Risk
- Drug Transport and Resistance Mechanisms
Guilin Medical University
2020-2025
University of South China
2011-2021
Morehouse School of Medicine
1993-2016
Stockholm University College of Music Education
2002
National Center for Infectious Diseases
1993
Perfluorooctane sulfonate (PFOS), a ubiquitous environmental pollutant, is neurotoxic to mammalian species. However, the underlying mechanism of its neurotoxicity was unclear. We hypothesized that PFOS suppresses BDNF expression produce effects by inhibiting ERK-CREB pathway. SH-SY5Y human neuroblastoma cells were exposed various concentrations examine role BDNF-ERK-CREB signalling pathway in PFOS-induced apoptosis and cytotoxicity. Furthermore, ascertain which reduces signalling, we...
The liver is the primary target organ for perfluorooctane sulphonate (PFOS), a recently discovered persistent organic pollutant. However, mechanisms mediating hepatotoxicity remain unclear. Herein, we explored relationship between reactive oxygen species (ROS) and autophagy apoptosis induced by PFOS in L-02 cells, which are incubated with different concentrations of (0, 50, 100, 150, 200, or 250 μmol/L) 24 48 hrs at 37°C. results indicated that exposure decreased cell activities, enhanced...
ABSTRACT Perfluorooctanyl sulfonate (PFOS), a cardiac toxicity compound, has been widely detected in the environment and organisms. However, toxic mechanism is not clear. Our previous study indicated that prenatal PFOS exposure led to swollen mitochondrial with vacuolar structure loss of cristae offsping's heart. The purpose this was investigate effect on apoptosis developing heart mitochondria‐mediated pathway. Pregnant Sprague‐Dawley (SD) rats were exposed at doses 0.1, 0.6, 2.0 mg/kg‐d...
Perfluorooctane sulfonate (PFOS), a new kind of persistent organic pollutant, is widely distributed in the environment and exists various organisms, where it also neurotoxic compound. However, potential mechanism its neurotoxicity still unclear. To examine role epigenetics induced by PFOS, SK-N-SH cells were treated with different concentrations PFOS or control medium (0.1% DMSO) for 48 h. The mRNA levels DNA methyltransferases (DNMTs) Brain-derived neurotrophic factor (BDNF), microRNA-16,...
Bisphenol S (BPS) is an environmental endocrine disruptor widely used in industrial production. BPS induces oxidative stress and exhibits male reproductive toxicity mice, but the mechanisms by which impairs steroid hormone synthesis are not fully understood. Nuclear factor erythroid 2-related 2(Nrf2)/HO-1 signaling a key pathway improving cellular antioxidant defense capacities. Therefore, this study explored effects of exposure to on testosterone adult mice its with regard Nrf2/HO-1...
Abstract Bisphenol S (BPS) is associated with neurotoxicity, but its molecular mechanisms are unclear. Our aim was to investigate the role of brain‐derived neurotrophic factor (BDNF)/tyrosine kinase B (TrkB)/cAMP‐response element‐binding protein (CREB) signaling pathway in BPS‐induced cytotoxicity SK‐N‐SH cells. The cells were treated various concentrations BPS, and cell viability, apoptosis rate, mitochondrial membrane potential (MMP), BDNF, cleaved‐caspase‐3, B‐cell lymphoma 2 (Bcl‐2),...
Bisphenol S (BPS) is an environmental pollutant that can accumulate in the human body and cause harm. Puerarin (PUE) a flavonoid with anti-inflammatory antioxidant effects. In this study, we used 50 mg/kg/d BPS as poison PUE intervention for model mice 42 d. exposure significantly increased levels of impairment mice’s liver function, T-CHO, TG, LDL-C, ALT, AST group were (p < 0.05). Additionally, caused inflammatory cell infiltration tissue enhanced oxidative stress response, level MDA...
The reproductive toxicity of bisphenol S (BPS) in male mammals and its possible mechanism are not clear. We investigated the effects action BPS on adult C57BL/6 mice. found that exposure to 200-mg/kg resulted a significant decrease sperm count caput/corpus cauda epididymis, significantly decreased motility, increased deformity. Histological evaluation revealed caused spermatozoa lumen seminiferous tubules reduction proportion Stage VII or VIII BPS-treated groups. Furthermore, ultrastructure...
AbstractTo determine the effects of protein malnutrition on severity and duration infection with Giardia lamblia, Mongolian gerbils were pair-fed a pelleted control (C) diet (20% protein) low-protein (.5%; LP) for 3 weeks before after being infected 100,(MM) cysts orallv. Weight loss, fecal fat, enteropooling. cyst excretion all greater in LP than C animals. During peak upper intestinal intraepithelial lymphocyte infiltration, crypt enlargement, villus enterocyte migration animals, as was...
Abstract Background The flowers and dried fruit spikes of Prunella vulgaris L. ( P. L.) have been widely used in traditional Chinese medicine food. is regarded as a good option for treating uterine myoma (UM). However, scientific evidence anti-UM activity the extract (PVE) lacking. present study aimed to characterize chemical composition PVE evaluate pharmacodynamics mechanism against UM. Methods was analyzed by GC-MS. MTT screen cell proliferation toxicity. Double fluorescence flow...
Abstract. The effect of radiation on TK is more complicated than would be expected from earlier results bone marrow cells ( Feinendegen et al. 1984 , Int. J. Radiat. Biol. 45, 205). activity increased at 0.01 Gy and then decreased up to 1 in mouse spleen. In contrast the for spleen, an increase 0.1 was seen thymus. dephosphorylated TK1 (TK1a) both spleen thymus reduced 50% after irradiation 0.5–1 Gy. degree phosphorylation (TK1b/TK1a ratio) changed but not TK2 liver 3 h 5 by about 60%....
Chlamydophila psittaci ( C. ) is a human zoonotic pathogen, which could result in severe respiratory disease. In the present study, we investigated role and mechanism of type III secretion system (T3SS) regulating inflammatory response host cells. -infected THP-1 cells were incubated with specific T3SS inhibitor INP0007, inhibitors ERK, p38, or JNK, levels cytokines analyzed using Q-PCR ELISA. The JNK phosphorylation by Western blot. Our results verified that INP0007 inhibited chlamydial...
Ulcerative colitis (UC) is the most common inflammatory bowel disease, and its incidence has increased in recent years. Recent clinical experimental data indicate that gut microbiota plays a pivotal role pathogenesis of UC. Chlamydia establishes stable persistent colonization gastrointestinal tract without apparent pathogenicity to or extragastrointestinal tissues. However, detailed effects on tissue remain unknown. The primary aim this study investigate muridarum (C. muridarum) development...
The study is to investigate the effect of anti-caspase treatment on anti-chlamydia immune response in mice. Both humoral and aspects cell-mediated against Chlamydia trachomatis were studied. Antibody was measured using ELISA technique identify all common isotypes, cytokine PCR technique. antibody levels (IgG, IgG1, IgG2a IgA) Z-VAD-FMK treated group significantly higher than nontreated group. results [showed a amount antibodies Ig G2a Original Research Article
Objective To study the possible molecular mechanism of IL-10 in promoting Chlamydia muridarum infection mice. Methods C57BL/6 wild-type and gene knockout (IL-10-/-) mice were infected with muridarum. Indirect immunofluorescence assay was used to detect growth intestinal genital tracts. The severity diseases assessed by hydrosalpinx scoring. Expression IFN-γ IL-2 blood measured ELISA. Results Compared group, clearance tracts IL-10-/- significantly faster, expression increased...