A5100367703- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Urban Transport and Accessibility
- Coronary Interventions and Diagnostics
- Transportation Planning and Optimization
- Parathyroid Disorders and Treatments
- Nephrotoxicity and Medicinal Plants
- Spinal Cord Injury Research
- Traffic control and management
- Atherosclerosis and Cardiovascular Diseases
- Renal Diseases and Glomerulopathies
- Electron Spin Resonance Studies
- Nuclear Receptors and Signaling
- Hearing, Cochlea, Tinnitus, Genetics
- Exercise and Physiological Responses
- Advanced MRI Techniques and Applications
- Kruppel-like factors research
- Vascular Anomalies and Treatments
- Autophagy in Disease and Therapy
- Pulmonary Hypertension Research and Treatments
- Anesthesia and Neurotoxicity Research
- Macrophage Migration Inhibitory Factor
- Ocular Surface and Contact Lens
Shandong Eye Hospital
2025
Shandong First Medical University
2025
Shanghai Jiao Tong University
2014-2024
Shanghai Chest Hospital
2021-2024
Inner Mongolia People's Hospital
2022
Beijing Fengtai Hospital
2021
Beijing University of Chinese Medicine
2021
Renji Hospital
2015-2017
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
Tulane University
2014
The multiclass network equilibrium problem is investigated under a tradable credit scheme. social planner initially distributes certain number of credits to all eligible travelers, charges link-specific from travelers using that link, and allows for free trading the among travelers. Travelers are assumed be heterogeneous with continuously distributed value time (VOT). For given scheme VOT distribution, combined user market formulated into an infinite-dimensional variational inequality...
Background Contrast‐induced acute kidney injury ( CI ‐ AKI ) is typically defined by an increase in serum creatinine after intravascular administration of contrast medium. Because unreliable indicator changes function, we assessed whether circulating micro RNA s (mi s) could serve as biomarkers for early detection . Methods and Results Using a rat model , first evaluated the mi profile plasma kidney. Three species with >1.5‐fold samples rats, including ‐188, ‐30a, ‐30e, were selected...
Allograft rejection remains a major cause of failure in high-risk corneal transplants, but the underlying mechanisms are not fully understood. This study aimed to investigate contribution transplantation stress-induced cellular senescence allograft and elucidate associated molecular mechanisms. Age-matched murine models were established. Cellular was evaluated using senescence-associated β-galactosidase (SA-β-Gal) staining, western blot, immunofluorescence staining. The role analyzed p16...
Statins are a promising new strategy to prevent contrast‐induced acute kidney injury (CI‐AKI). In this study we compared the ameliorative effect of different statins in rat model CI‐AKI. Sprague‐Dawley rats were divided into five groups: control group; CI‐AKI + rosuvastatin group (10 mg/kg/day); simvastatin (80 and atorvastatin (20 mg/kg/day). was induced by dehydration for 72 hours, followed furosemide intramuscular injection 20 minutes before low‐osmolar contrast media (CM) intravenous...
Shear stress, particularly low and oscillatory shear plays a critical pathophysiological role in vascular remodeling-related cardiovascular diseases. Growing evidence suggests that the orphan nuclear receptor Nur77 [also known as TR3 or subfamily 4, group A, member 1 (NR4A1)] is expressed diseased human tissue an important physiology pathology. In present study, we used mouse model of flow-dependent remodeling by partial ligation left common carotid artery (LCCA) to define exact induced...
Contrast-induced acute kidney injury (CI-AKI) was traditionally defined as an increase in serum creatinine (sCr) after contrast media exposure. Recently, cystatin C (sCyC) has been proposed alternative to detect changes renal function. The clinical implications of combining sCyC and sCr diagnose CI-AKI remain unknown.One thousand seventy-one consecutive patients undergoing coronary angiography/intervention were prospectively enrolled. SCyC assessed at baseline 24 48 hours determined by...
Microinflammation plays a crucial role in podocyte dysfunction diabetic nephropathy, but its regulatory mechanism is still unclear. This study aimed at discussing the mechanisms underlying effect of miRNA-155 on injury to determine potential as therapeutic target. Cultured immortalized mouse podocytes and KK-Ay mice models were treated with miR-155 inhibitor. Western blotting, real-time PCR, ELISA, immunofluorescence, Luciferase reporter assay used analyze markers inflammation cytokines...
The aim of this study was to assess the preventive effect xuezhikang (XZK) replace atorvastatin on contrast media-induced acute kidney injury (CI-AKI).The male Sprague-Dawley rats were divided into five groups: group 1 (sham), injected with normal saline; 2 (XZK), treated XZK; 3 media (CM), CM; 4 (CM + ATO), CM pretreatment atorvastatin; 5 XZK), XZK. Twenty-four hours after injection saline or CM, blood sample and kidneys collected for measurement biochemical parameters, oxidative stress...
Abstract Background: The aim of the study was to evaluate efficacy nicorandil and alprostadil on myocardial protection in patients undergoing elective percutaneous coronary intervention (PCI). Methods: In this prospective, single-blinded, randomized controlled study, 90 consecutive scheduled for PCI de novo lesions were assigned nicorandil, alprostadil, nitroglycerin groups a 1:1:1 ratio. Drugs administered intracoronary via targeted perfusion microcatheter. primary endpoint thrombolysis...
Macrophage apoptosis coupled with a defective phagocytic clearance of the apoptotic cells promotes plaque necrosis in advanced atherosclerosis, which causes acute atherothrombotic vascular disease. Nonsteroidal anti-inflammatory drug sulindac derivative K-80003 treatment was previously reported to dramatically attenuate atherosclerotic progression and destabilization. However, underlying mechanisms are not fully understood. This study aimed determine role on macrophage elucidate...
ASL has been widely used in neuroimaging studies to measure the metabolic activity of local brain microstructure due its advantages no radiation damage, introduction exogenous contrast agent, high repeatability and fast scanning time. In this study, perfusion imaging was analyze changes cerebral blood during normal sleep deprivation.
INTRODUCTION Ectopically located hyperfunctioning parathyroid gland(s) are responsible for approximately 6–16% of hyperparathyroidism cases, in which about 6% can be ascribed to ectopic growth the mediastinal site.[1] Treatment adenomas usually requires resection. There various techniques resect glands, mainly depended on gland's location. However, choosing correct type treatment cases difficult since there no commonly accepted guidelines selection. Here, we reported a male patient, whose...
Background: It remains controversial whether contrast-associated acute kidney injury (CA-AKI) is associated with long-term major adverse events (MAKE) in patients ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Methods: By the Acute Kidney Injury Network (AKIN) criteria, CA-AKI was defined as an increase serum creatinine ≥ 0.3 mg/dL or 50% from baseline within 48 h after PCI; 0.5 25% 72 by contrast-induced nephropathy (CIN)...
Objective With a GcneChip(R) cxpression analysis,98 known gencs and 31 exprcssed sequence tags (ESTs) were found to be differentially expressed between KK/Ta BALB/c kidneys.To further screen the susceptibility genes for diabetic nephropathy,the temporal spatial expression patterns of gene-adipsin investigated.Methods The body weight,blood glucose,urinary albumin/creatinine ratio,and renal pathological changes mice measured at 7,20,28 36 weeks age.Total RNA was extracted from...
The optimum therapy for coronary slow flow phenomenon (CSFP) stays debatable. This study compared the effectiveness of alprostadil with isosorbide dinitrate in alleviating angina episodes CSFP patients.In this prospective, randomized controlled study, 102 patients without severe artery stenosis that exhibited stable were allocated randomly a ratio 1:1 to either group (40 μg, three times per day, n = 51) or (5 mg, 51). Frequency events, intensity suffering, and Canadian Cardiovascular Society...