A5036555875- Research on Leishmaniasis Studies
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Sarcoma Diagnosis and Treatment
- Cancer and Skin Lesions
- Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Soft tissue tumor case studies
- Lung Cancer Diagnosis and Treatment
- Tumors and Oncological Cases
- Autoimmune and Inflammatory Disorders Research
- Poisoning and overdose treatments
- Neurofibromatosis and Schwannoma Cases
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Trypanosoma species research and implications
- Ear and Head Tumors
- Nonmelanoma Skin Cancer Studies
- Vascular Malformations and Hemangiomas
- Estrogen and related hormone effects
- Immune responses and vaccinations
- Parasites and Host Interactions
- Photodynamic Therapy Research Studies
- Women's cancer prevention and management
- Urinary and Genital Oncology Studies
Instituto de Gastroenterologia de Goiânia
2010-2025
Clinica Universidad de Navarra
2025
Universidade Federal de Goiás
2012-2022
St. Albans School
2020
Universidade Federal de Minas Gerais
2009
Hospital Araújo Jorge
2006
IPO Porto
2003
The vitamin D pathway contributes to the microbicidal activity of macrophages against Leishmania infection. In addition induction this pathway, interferon-gamma (IFNγ), interleukin (IL)-15, and IL32γ are part a network pro-inflammatory cytokines. aim study was evaluate single-nucleotide polymorphisms (SNPs) in components associated cytokine genes that could be related resistance or susceptibility American tegumentary leishmaniasis (ATL). expressions IFNG, IL15, IL32, CYP27B1, VDR, other...
Diffuse cutaneous leishmaniasis (DCL) is characterized by disseminated lesions and the absence of a specific cellular immune response. Here, immunochemotherapy outcome patient with DCL from Amazonian Brazil infected Leishmania (Leishmania) amazonensis presented. After several unsuccessful chemotherapy treatment regimens many relapses, monthly immunotherapy scheme L. PH8 plus (Viannia) braziliensis M2903 monovalent vaccines associated Bacillus Calmette-Guerin (BCG) was established, one round...
The interleukin 32 (IL-32) is a proinflammatory cytokine produced by immune and non-immune cells. It can be induced during bacterial viral infections, but its production was never investigated in protozoan infections. American Tegumentary Leishmaniasis (ATL) caused Leishmania leading to cutaneous, nasal or oral lesions. aim of this study evaluate the expression IL-32 cutaneous mucosal lesions as well peripheral blood mononuclear cells (PBMC) exposed (Viannia) braziliensis. IL-32, tumour...
Background Sun exposure may lead to actinic keratoses (AKs), field cancerization, and skin cancer. Effective treatment of AKs cancerization is important. Oral topical retinoids can be used for this purpose. To compare clinical, histological, immunohistochemical effects oral retinoid on face upper limbs immunocompetent patients, as well the impact quality life, safety, tolerability. Methods This study compared 10 mg/day isotretinoin (ISO) 0.05% tretinoin cream (TRE) every other night,...
Leishmania (Viannia) braziliensis causes cutaneous and mucosal leishmaniasis in several countries Latin America. In mammals, the parasites live as amastigotes, interacting with host immune cells stimulating cytokine production that will drive type of specific responses. Generation Th17 lymphocytes is associated tissue destruction depends on IL-1β, IL-6, TGF-β IL-23 production, whereas IL-10 are protection. Here, we evaluate whether amastigotes stimulate peripheral blood mononuclear (PBMCs)...
Isolation of Leishmania parasite and species identification are important for confirmation to help define the epidemiology leishmaniasis. Mice often used isolate pathogens, but most common mouse strains resistant infection with parasites from (Viannia) subgenus. In this study we tested inoculation interferon gamma knockout (IFNgamma KO) mice biopsy macerates Leishmania-infected patients increase possibility isolating parasites. Biopsies twenty five clinical signs leishmaniasis were taken...
Interleukin-32 is a novel inflammatory mediator that has been described to be important in the immunopathogenesis and control of infections caused by Leishmania parasites. By performing experiments with primary human cells vitro, we demonstrate expression IL-32 isoforms dependent on time exposed L. amazonensis braziliensis antigens. Moreover, for first show functional consequences three different genetic variations IL32 (rs4786370, rs4349147, rs1555001) modulating IL-32γ expression,...
Visceral leishmaniasis (VL) is a chronic parasitic disease caused by Leishmania infantum in the Americas. During VL, several proinflammatory cytokines are produced spleen, liver, and bone marrow. However, role of interleukin-32 (IL-32) has not been explored this disease. IL-32 can induce production innate immune cells polarize adaptive response. Herein, we discovered that L. antigens induced expression mRNA mainly for IL-32γ isoform but also low levels IL-32β transcript human peripheral...
Esophagitis caused by herpes simplex virus (HSV) is often documented during periods of immunosuppression in patients infected with human immunodeficiency (HIV); it rare immunocompetent diagnosed patients. Case reports herpetic esophagitis students health sciences are extremely rare. The disease presents a clinical picture characterized acute odynophagia and retrosternal pain without obvious causes ulcers, evidenced endoscopically the middistal esophagus. Diagnosis depends on endoscopy,...
Abstract Objective to report clinical and pathological features of patients with colorectal cancer diagnosed during emergency abdominal surgery. Methods records 107 operated between 2006 2010 were reviewed. Results there 58 women 49 men mean age 59.8 years. The most frequent symptoms were: pain (97.2%), no bowel movements (81.3%), vomiting (76.6%), anorexia (40.2%). Patients divided into five groups: obstructive acute abdomen (n = 68), perforation 21), inflammation 13), sepsis 3), severe...
The disseminated form of leishmaniasis is a serious and rare disease, being diagnosed in 2% the cutaneous cases registered per year Brazil. main characteristic appearance multiple pleomorphic lesions on surface. A 68-year-old male from rural area Tocantins, Brazil, presented atypical (ACL). clinical course histopathological immunological findings mixed pattern that hindered diagnosis therapeutic management. Molecular typing revealed infection with Leishmania (V.) guyanensis (L.) amazonensis....
SUMMARY Primary osteosarcoma of the breast (POB) is an extremely rare and aggressive tumor. Differential diagnosis POB includes chest wall metaplastic carcinoma. Imaging tests that exclude existence a direct connection between tumor wall, as well histopathological immunohistochemical studies rule out presence epithelial component are required for POB. We report case 69-year old woman with pathological findings presented. Therapeutic approach discussed in light current knowledge, including...
A pneumonia lipoide é uma doença pouco diagnosticada, causada pela aspiração de partículas oleosas para dentro dos pulmões. Os casos relatados têm sido relacionados ao uso óleo mineral como laxativo, mas outras soluções também podem causar a doença. Relatamos o caso paciente 50 anos com queixa tosse produtiva, sendo diagnosticada inicialmente hiper-reatividade brônquica e do refluxo gastroesofágico (DRGE). foi submetida tratamento DRGE. Devido à persistência da tosse, TC tórax,...
Tegumentary leishmaniasis is an endemic protozoan disease that, in Brazil, caused by parasites from Viannia or Leishmania complex. The clinical forms of cutaneous comprise localized, disseminated, mucosal mucocutaneous, and diffuse leishmaniasis. complex are not easy to isolate patient lesions, especially they difficult culture. aim the present study was compare efficiency ex vivo (culture) (IFNγ-deficient mice) parasite isolation methods improve rate storage stocks New World sp that cause...
bladder and another at the left ureterovesical junction, contributing to selection of appropriate practice success surgical procedure.In our review literature, we found no other reports a ureteral calculus in patient with inguinoscrotal hernia bladder.
The aim of this study was to characterize clinical field isolates Leishmania spp. obtained from patients with American Tegumentary Leishmaniasis (ATL) who live in Goiás state, Brazil. presumed areas infection were Goiás, Tocantins, and Pará states. Three parasites identified as L. (Viannia) braziliensis one (V.) guyanensis . vitro growth profiles found be similar for all parasites. Nevertheless, C57BL/6 mice, better controlled than Yet mice deficient interferon gamma, lesions developed...
A 6 year-old patient began to experience localized hairloss in the right temporal region three years ago. During first appointment, diagnoses of alopecia areata and congenital triangular were made. After one year, there was no change. Upon dermatological examination, non-scarring noted region, revealing extremely fine fair hair follicles. dermoscopy revealed only thin vellus-type hairs. Congenital is a condition commonly confused with thus underdiagnosed. However, well-established clinical...
Abstract Phenotypic and functional aspects of monocytes from Localized Cutaneous Leishmaniasis (LCL) patients were evaluated. The frequencies monocyte subsets TLR2/TLR4 expression evaluated in fresh peripheral blood whereas cytokine production was whole cell cultures stimulated with TLR agonists or Leishmania braziliensis antigen (Ag). CD16 + frequency increased compared controls. A TLR4 agonist (LPS) induced TNF IL‐10 CD14 expressed higher levels these cytokines than − cells. secreted...
Objectives To compare the effects of tamoxifen and raloxifene on proliferative activity normal breast tissue in premenopausal women as measured by Ki-67/MIB-1 expression. Study Design A total 48 with benign nodules a recommendation for surgical removal lesion took part this study. They were randomized to use or 22 days, after which they submitted surgery. During procedure, 1-cm fragment was removed study Ki-67 Results The mean percentage ratios between immunolabeled non-labeled cells 2.02 ±...