A5065761269- MicroRNA in disease regulation
- Circular RNAs in diseases
- BRCA gene mutations in cancer
- Peroxisome Proliferator-Activated Receptors
- Bone Metabolism and Diseases
- Cancer, Lipids, and Metabolism
- Bone health and treatments
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Protein Degradation and Inhibitors
- Angiogenesis and VEGF in Cancer
- Metabolism, Diabetes, and Cancer
- Nutrition, Genetics, and Disease
- Extracellular vesicles in disease
- Sarcoma Diagnosis and Treatment
- Free Radicals and Antioxidants
- Pharmacology and Obesity Treatment
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Genetics and Physical Performance
- Sulfur Compounds in Biology
- Neuroblastoma Research and Treatments
- Retinoids in leukemia and cellular processes
- Lipid metabolism and disorders
CRUK Lung Cancer Centre of Excellence
2017-2023
University College London
2017-2023
Cancer Institute (WIA)
2018
University of Palermo
2010-2016
Weatherford College
2012
MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of different genes, including genes involved in cancer progression. A functional link between hypoxia, a key feature tumor microenvironment, and miRNA has been documented. We investigated whether how miR-20b can vascular endothelial growth factor (VEGF) MCF-7 breast cells under normoxic hypoxia-mimicking conditions (CoCl(2) exposure). Using immunoblotting, ELISA, quantitative real-time PCR, we demonstrated decreased...
Recent findings indicate that exosomes released from cancer cells contain microRNAs (miRNAs) may be delivered to of tumor microenvironment. To elucidate whether miRNAs secreted chronic myelogenous leukemia (CML) are shuttled into endothelial thus affecting their phenotype, we first analysed content in LAMA84 exosomes. Among the 124 identified exosomes, focused our attention on miR-126 which was found over-overexpressed compared with producing parental cells. Transfection Cy3-labelled and...
Pemetrexed has been widely used in patients with advanced non-small cell lung cancer (NSCLC). The clinical relevance of polymorphisms folate pathway genes for pemetrexed metabolism have not fully elucidated yet. aim this study was to evaluate the expression levels circulating miR-22, miR-24, and miR-34a, possibly involved pathway, NSCLC treated compared healthy controls investigate their impact on patient outcomes. A total 22 consecutive NSCLC, pemetrexed-based chemotherapy 27 age sex...
Cell migration through the brain parenchyma underpins neurogenesis and glioblastoma (GBM) development. Since GBM cells neuroblasts use same migratory routes, mechanisms underlying during cancer pathogenesis may be similar. Here, we identify a common pathway controlling cell in normal neoplastic CNS. The nuclear scaffold protein promyelocytic leukemia (PML), regulator of forebrain development, promotes neural progenitor/stem (NPC) neuroblast adult mouse brain. PML pro-migratory role is active...
Abstract Finding new treatments targeting cancer stem cells (CSCs) within a tumor seems to be critical halt and improve patient survival. Osteosarcoma is an aggressive affecting adolescents, for which there no second‐line chemotherapy. Uncovering molecular mechanisms underlying the development of osteosarcoma origin CSCs crucial identify possible therapeutic strategies. Here, we aimed characterize genetically molecularly human 3AB‐OS CSC line, previously selected from MG63 proved have both...
miRNAs are attractive molecules for cancer treatment, including colon rectal (CRC). We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 (TSP-1) expression, a protein downregulated in CRC and inversely correlated with tumor vascularity metastasis.MicroRNAs small non-coding RNAs that expression of different genes, involved progression, angiogenesis metastasis. miR-182, over-expressed colorectal (CRC), has like predictive target (TSP-1), metastasis results...
The obesity hormone leptin has been implicated in breast cancer development. Breast cells express the receptor and are able to synthesize response obesity-related stimuli. Furthermore, is a positive regulator of vascular endothelial growth factor (VEGF) high levels both proteins associated with worse prognosis patients. Peroxisome proliferator-activated γ (PPARγ) ligands therapeutic agents used patient Type 2 diabetes which have recently studied for their potential anti-tumor effect. Here,...
Zoledronic acid (ZOL), belonging to third generation bisphosphonate family, is a potent inhibitor of osteoclast-mediated bone resorption, widely used effectively prevent osteolysis in breast cancer patients who develop metastases. Low doses ZOL have been shown exhibit direct anticancer role, by inhibiting cell adhesion, invasion, cytoskeleton remodelling and proliferation MCF-7 cells. In order identify the molecular mechanisms signaling pathways underlying activity exerted ZOL, we analyzed...
Zoledronic acid (ZOL) is the most potent nitrogen-containing bisphosphonate (N-BPs) that strongly binds to bone mineral and acts as a powerful inhibitor of resorption, already clinically available for treatment patients with osteolytic metastases. Recent data also suggest ZOL, used in breast cancer, may provide more than just supportive care modifying course disease, though possible molecular mechanism action still unclear.As cancer one primary tumours high propensity metastasize bone, we...
Glioblastoma is thought to originate from neural stem cells (NSCs) of the subventricular zone that acquire genetic alterations. In adult brain, NSCs are largely quiescent, suggesting deregulation quiescence maintenance may be a prerequisite for tumor initiation. Although inactivation suppressor p53 frequent event in gliomagenesis, whether or how it affects quiescent (qNSCs) remains unclear. Here, we show maintains by inducing fatty-acid oxidation (FAO) and acute deletion qNSCs results their...