A5086416668- Thyroid Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Extracellular vesicles in disease
- Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Histiocytic Disorders and Treatments
- Cancer Cells and Metastasis
- Vascular Tumors and Angiosarcomas
- Circular RNAs in diseases
- MicroRNA in disease regulation
- BRCA gene mutations in cancer
- RNA Interference and Gene Delivery
- Gene expression and cancer classification
- Innovations in Medical Education
- Head and Neck Anomalies
- Vitamin D Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Proteomics Techniques and Applications
- Regulation of Appetite and Obesity
- Neuroblastoma Research and Treatments
- Vascular Malformations and Hemangiomas
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Ear and Head Tumors
St. Luke's Medical Center
2024
Loma Linda University Medical Center
2016-2021
Loma Linda University
2006-2021
Abstract Background The inhibitor of apoptosis (IAP) protein Survivin and its splice variants are differentially expressed in breast cancer tissues. Our previous work showed is released from tumor cells via small membrane-bound vesicles called exosomes. We, therefore, hypothesize that analysis serum exosomal may provide a novel biomarker for early diagnosis cancer. Methods We collected sera forty patients ten control who were disease free 5 years after treatment. In addition, twenty-three...
Based on the American College of Surgeons Oncology Group Z0011 trial exclusion criteria, patients with T1N0 or T2N0 breast cancer 1 2 positive sentinel lymph nodes (SLNs) are recommended to undergo axillary node dissection if extranodal extension (ENE) is present.OBJECTIVE To determine effect ENE size residual nodal burden, disease recurrence, and survival in meeting criteria. DESIGN, SETTING, AND PARTICIPANTSRetrospective cohort study between January 1, 2000, December 31, 2012, at a single...
Abstract Background The purpose of this study was to evaluate our surgical experience in patients with primary hyperparathyroidism (PHPT) nonlocalizing sestimibi and ultrasound scans. Methods A retrospective review 521 treated from April 2005 July 2017 at Loma Linda University Medical Center who received parathyroidectomy for PHPT. One hundred forty‐seven (28%) had double negative localization (nonlocalizing sestamibi ultrasound). Results Surgical cure PHPT 97.3% 99.2% nonlocalized localized...
Objective This study aims to determine the cost effectiveness of rapid frozen section (RFS) for indeterminate thyroid nodules. Materials and methods A retrospective chart review was conducted between January 2009 June 2013 at a tertiary care institution. Main outcomes were number needed treat, RFS efficacy, cost-savings avoiding second completion thyroidectomy. Cost-effectiveness estimated using 2015 Medicare reimbursement rate. Results Out 1,114 patients undergoing surgery, 314 had...
35 Background: The inhibitor of apoptosis (IAP) protein Survivin and its splice variants are differentially expressed in breast cancer tissues have recently been shown to be released from tumor cells via small membrane-bound vesicles called exosomes. Tumor-derived exosomes play multiple roles growth metastasis may produce these functions by impacting immune escape, invasion angiogenesis. We, therefore, hypothesize that analysis exosomal provide a novel biomarker for early diagnosis addition...
Gangliocytic paraganglioma (GP) is a rare neuroendocrine tumor almost exclusively found in the ampulla. It considered nonfunctioning literature. We herein report first case of functioning GP arising Our patient had constellation ampullary tumor, flushing, diarrhea, weight loss, diabetes mellitus, and cholelithiasis, consistent with effects serotonin somatostatin that were overexpressed by tumor. The serum level was elevated. Immunostaining confirmed expression epithelioid cells ganglion-like...
Neoplastic seeding of head and neck carcinomas is a well-documented but relatively rare occurrence. We report case sinonasal adenoid cystic carcinoma to tracheostomy site.
Hemangioendothelioma is a vascular tumor with several different morphologic patterns that can include component of ovoid or spindled cells, but generally lacks an inflammatory component. The combined and immunohistochemical features are sufficient to accurately diagnose this its many variants. We present challenging lymphocyte-rich soft tissue lesion was not recognized be unusual hemangioendothelioma until after recurrences in the arm 63 year-old male, which originally diagnosed as...
Background: Biomarkers to predict the recurrence risk are required optimize perioperative treatment. Adjuvant chemotherapy for patients with human epidermal growth factor 2-positive (HER2-positive) early breast cancer is decided by pathological responses of neoadjuvant (NAC). However, whether appropriate biomarkers unclear. Currently, there several studies using minimal residual disease (MRD) as a predictor prognosis in solid tumors. no standard method detecting MRD. Objectives: This study...
The World Health Organization classifies primary sinonasal adenocarcinomas (SNACs) into salivary and non-salivary types. Non-salivary SNACs are separated intestinal-type (ITAC) non-ITAC, with both having low- high-grade categories. Low-grade non-ITAC is the most uncommon hence one of least-thought-of differential diagnoses. In contrast to ITAC, a less aggressive adenocarcinoma better clinical outcome. Therefore, its recognition reliable separation from benign glandular proliferations or more...
Abstract Thyroid cancer affects ethnic groups at different rates and severity. Despite this, thyroid health disparities are still an understudied area. Our laboratory has shown a differential expression of vitamin D binding protein (DBP) in Filipino Americans (FA) versus European (EA) [1]. Higher DBP levels correlate to better prognosis. A study revealed DBP-dependent receptor (VDR) promoter activation. In this study, we investigated whether VDR expressed differentially groups, such as...
Abstract Filipino Americans (FA) are known to have higher rates of thyroid cancer incidence and disease recurrence compared European (EA). FA also be two times more likely die EA. Epidemiological studies in California shown that is the second most common among women. Currently, there no demonstrate mechanism behind these discrepancies. Evidence shows a strong correlation between obesity aggressive forms cancer; has an increased frequency populations. The exact connection mechanisms poorly...