A5044323720- Hepatocellular Carcinoma Treatment and Prognosis
- Spectroscopy Techniques in Biomedical and Chemical Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Electron Spin Resonance Studies
- Lipid metabolism and biosynthesis
- Lanthanide and Transition Metal Complexes
- Biosensors and Analytical Detection
- Venous Thromboembolism Diagnosis and Management
- Cancer-related molecular mechanisms research
- Bladder and Urothelial Cancer Treatments
- Nanoplatforms for cancer theranostics
- Lung Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Photoacoustic and Ultrasonic Imaging
- Radiomics and Machine Learning in Medical Imaging
- Abdominal vascular conditions and treatments
- Infrared Thermography in Medicine
- Gallbladder and Bile Duct Disorders
- Renal Diseases and Glomerulopathies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Physical Activity and Health
- Ultrasound and Hyperthermia Applications
- Circular RNAs in diseases
- Adipose Tissue and Metabolism
Stony Brook School
2025
Stony Brook University
2025
City Of Hope National Medical Center
2024
University of Missouri
2013-2024
Kent State University
2023
Stanford University
2017-2021
Loma Linda University
2020-2021
University of Missouri Hospital
2018-2021
Medical Education Institute
2019
Keogh Institute for Medical Research
2019
Summary Calcium signals are critical for the regulation of polarized growth in many eukaryotic cells, including pollen tubes and neurons. In plants, regulatory pathways that code decode Ca 2+ poorly understood. Arabidopsis thaliana, genetic evidence presented here indicates tube tip involves redundant activity two ‐dependent protein kinases (CPKs), isoforms CPK17 ‐34. Both appear to target plasma membrane, as shown by imaging CPK17–yellow fluorescent (YFP) CPK34–YFP growing tubes....
There is sparse information about specific storage and handling protocols that minimize analytical error variability in samples evaluated by targeted metabolomics. Variance components affect quantitative lipid analysis a set of human serum were determined. The effects freeze-thaw, extraction state, temperature, freeze-thaw prior to density-based lipoprotein fractionation quantified. quantification high abundance metabolites, representing the biologically relevant species humans, was highly...
Bladder cancer has the highest recurrence rate of all cancers due in part to inadequate transurethral resection. Inadequate resection is caused by inability cystoscopes detect invisible lesions during procedure. To improve detection and nonmuscle invasive bladder cancer, we quantified ability a surface-enhanced Raman nanoparticle endoscope system classify tissue as normal or cancerous. Both antibody-based (active) permeability-based (passive) targeting mechanisms were evaluated topically...
In analyzing the sequence tags for mutant mouse embryonic stem (ES) cell lines in BayGenomics (a gene-trapping resource), we identified a novel gene, 1-acylglycerol-3-phosphate O-acyltransferase (Agpat6), with similarities to previously characterized glycerolipid acyltransferases. Agpat6's closest family member is another gene that have provisionally designated Agpat8. Both Agpat6 and Agpat8 are conserved from plants, nematodes, flies mammals. AGPAT6, which predicted contain multiple...
Triglyceride synthesis in most mammalian tissues involves the sequential addition of fatty acids to a glycerol backbone, with unique enzymes required catalyze each acylation step. Acylation at sn-2 position requires 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) activity. To date, seven Agpat genes have been identified based on activity and/or sequence similarity, but their physiological functions not well established. We generated mouse model deficient AGPAT6, which is normally...
Cancers of the gastrointestinal (GI) tract are among most frequent and lethal cancers worldwide. An important reason for this high mortality is that early disease typically asymptomatic, patients often present with advanced, incurable disease. Even in high-risk who routinely undergo endoscopic screening, lesions can be missed due to their small size or subtle appearance. Thus, current imaging approaches lack sensitivity specificity accurately detect incipient GI cancers. Here we report our...
Nanoparticles' enhanced permeation and retention (EPR) variations due to tumor heterogeneity in naturally occurring brain tumors are commonly neglected preclinical nanomedicine studies. Recent pathological studies have shown striking similarities between humans dogs, indicating that canine may be a valuable model evaluate nanoparticles' EPR this context. We recruited clinical cases with spontaneous investigate different pathologies using surface-enhanced Raman spectroscopy (SERS). used gold...
In vivo multiplexed imaging aims for noninvasive monitoring of tumors with multiple channels without excision the tissue. While most preclinical has provided a number multiplexing up to three, Raman surface-enhanced scattering (SERS) nanoparticles was suggested offer higher capability originating from their narrow spectral width. However, in SERS is still its infancy multichannel visualization tumors, which require both sufficient multiplicity and high sensitivity concurrently. Here we...
Raman spectroscopic imaging has shown great promise for improved cancer detection and localization with the use of tumor targeting surface enhanced scattering (SERS) nanoparticles. With ultrasensitive multiplexing capabilities that SERS to offer, scientists have been investigating several clinical applications could benefit from this unique strategy. Recently, there a push develop new image-guidance tools surgical resection help surgeons sensitively specifically identify margins in real...
Prospective studies comparing EUS-guided liver biopsy (EUS-LB) to percutaneous LB (PC-LB) are scarce. We compared the efficacy and safety of EUS-LB with those PC-LB in a prospective randomized clinical trial.Between 2020 2021, patients were enrolled (1:1 ratio). The primary outcome was defined as proportion ≥11 complete portal tracts (CPTs). sample size (n = 80) calculated based on assumption that 60% 90% group will have CPTs. secondary outcomes included whom diagnosis established, number...
Diet and fatty acid metabolism interact in yet unknown ways to modulate membrane composition certain cellular functions. For example, dietary precursors or metabolic products of n-3 differ their ability modify specific components. In the present study, effect 22:6n-3 its precursor, 18:3n-3, on selective accumulation by heart was investigated. The mass compositions individual phospholipids (PL) liver were quantified mice fed either (from crocodile oil) 18:3n-3 soybean for 13 wk. This study...
PURPOSE Post-thoracotomy pain syndrome is a common condition affecting up to 50% of post-thoracotomy patients. However, percutaneous computed tomography (CT)-guided intercostal nerve cryoablation may provide symptomatic benefit in chronic and/or refractory cases. METHODS A retrospective review our institution's comprehensive case log from October 2017 September 2018 for patients who underwent was analyzed. Thirteen with syndrome, medical management, were treated CT-guided cryoablation. Most...
The aim of the paper is to assess effectiveness a computer-based evaluation software for preclinical preparations and restorations when compared traditional faculty grading/evaluation. Forty-four Class I (#30-O) II (#30-MO) amalgam (#31-MO) were generated in setting by first-year dental students. Calibrated evaluated using validated rubric from operative class. scanned Planmeca PlanScan intraoral scanner graded Romexis E4D Compare Software. Each was against corresponding gold standard tooth...
Gpihbp1-deficient (Gpihbp1-/-) mice lack the ability to transport lipoprotein lipase capillary lumen, resulting in mislocalization of within tissues, defective lipolysis triglyceride-rich lipoproteins, and chylomicronemia. We asked whether GPIHBP1 deficiency catalytically active would alter composition triglycerides adipose tissue or perturb expression lipid biosynthetic genes. also perturbations gene expression, if they occur, be accompanied by reciprocal metabolic changes liver.The...
Inferior vena cava (IVC) filter placement still plays an essential role in preventing pulmonary embolism (PE) patients with contraindications to anticoagulant therapy. However, IVC does have long-term risks which may be mitigated by retrieving them as soon clinically acceptable. A dedicated clinic provides a potential means of assuring adequate follow-up and retrieval.To assess the efficacy our retrieval at improving rate patient follow-up, effective management, rates.During period August...
Primary appendiceal cancers are rare, and they generally present with liver and/or peritoneal metastases. Currently there no guidelines to treat metastatic cancer, hence treated as colorectal cancer. Combining Yttrium 90 (Y-90) radioembolization (RE) systemic chemotherapy early in the treatment of right sided colon has been shown improve survival. Based on this data, a combination Y-90 RE was used case cancer.A 76-year-old male presented emergency room progressive lower quadrant pain. A...
Solitary fibrous tumors are primary mesenchymal tumors, which may occur in any part of the body. Overall, these considered to have intermediate malignant potential with 5- and 10-year metastasis-free overall disease-specific survival rates 74% 55%, 89% 73%, respectively (Demicco et al, 2012). Herein we present an unusual case solitary involving ischioanal fossa a 19-year-old woman radiologic-pathologic correlation. This was complicated by extensive tumor vascularity thus managed preoperative...