A5010999786- RNA modifications and cancer
- Metal-Catalyzed Oxygenation Mechanisms
- DNA Repair Mechanisms
- Cancer-related molecular mechanisms research
- Galectins and Cancer Biology
- Immunotherapy and Immune Responses
- FOXO transcription factor regulation
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Airway Management and Intubation Techniques
- MicroRNA in disease regulation
- Cancer Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Anesthesia and Pain Management
- Anesthesia and Neurotoxicity Research
- PARP inhibition in cancer therapy
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Advanced Nanomaterials in Catalysis
- Metal-Organic Frameworks: Synthesis and Applications
- Cancer Mechanisms and Therapy
- Effects of Radiation Exposure
- Salivary Gland Tumors Diagnosis and Treatment
- Nanocluster Synthesis and Applications
- Metal complexes synthesis and properties
Gansu University of Traditional Chinese Medicine
2025
Nanjing University
2010-2024
Nanjing General Hospital of Nanjing Military Command
2012-2024
Xinjiang Agricultural University
2024
Southern Medical University
2014-2024
Shandong First Medical University
2024
Jinan Central Hospital
2024
Hegang People's Hospital
2016-2023
Nanjing Medical University
2017-2021
Beijing Tongren Hospital
2021
Background/Aims: Previously, we have shown that microRNA (miR)-149 suppresses the migration and invasion of colorectal cancer (CRC) cells by targeting forkhead box transcription factor (FOXM1). However, roles miR-149 in chemoresistance CRC to 5-Fluorouracil (5-FU) is unclear. The aim this study investigate whether targets FOXM1 regulate 5-FU resistance CRC. Methods: qRT-PCR assay was performed detect expression 5-FU-resistant (HCT-8/5-FU LoVo/5-FU) their parental (HCT-8 LoVo). Also, effects...
Cancer-associated fibroblasts (CAFs) are present in many types of tumors and play a pivotal role tumor progression immunosuppression. Fibroblast-activation protein (FAP), which is overexpressed on CAFs, has been indicated as universal target. However, FAP expression not restricted to tumors, systemic treatment against often causes severe side effects. To solve this problem, photodynamic therapy (PDT) approach was developed based ZnF
// Tao Xie 1, * , Jian Geng Ye Wang 1 Liya 2 Mengxi Huang Jing Chen Kai Zhang Lijun Xue Xiaobei Liu Mao Yanan Qian Tingting Dai Lili Ren Hongju Yu Rui Longbang Cheng Xiaoyuan Chu Department of Medical Oncology, Jinling Hospital, Nanjing Clinical School Southern University, 210002, China Medicine, These authors have contributed equally to this work Correspondence to: Chu, email: chuxiaoyuan000@163.com Chen, chencheng1289@126.com Keywords: colorectal cancer, FOXM1, 5-FU, chemoresistance...
Reliable risk assessment for biotherapeutics requires accurate evaluation of factors associated with immunogenicity. Immunogenicity tools were developed and applied to investigate the immunogenicity a fully human therapeutic monoclonal antibody, ATR-107 [anti-interleukin (IL)-21 receptor] that elicited anti-drug antibodies (ADA) in 76% healthy subjects Phase 1 study. Because target is expressed on dendritic cells (DCs), related engagement DC antigen presentation pathways was studied. Despite...
Background: Hypocalcemia is one of the most common postoperative complications following thyroid surgery in clinical practice. The occurrence hypocalcemia mainly attributed to hypoparathyroidism when parathyroid glands are devascularized, injured, or dissected during surgery. aim this study was analyze risk factors for and thyroidectomy. Patients methods: A total 278 patients who underwent were analyzed retrospectively. Univariate analysis multivariable logistic regression performed discover...
Ribonucleotide reductase subunit RRM2B (p53R2) has been reported to suppress invasion and metastasis in colorectal cancer (CRC). Here, we report that high levels of expression are correlated with markedly better survival CRC patients. In a fluorescence-labeled orthotopic mouse xenograft model, confirmed overexpression nonmetastatic cells prevented lung and/or liver metastasis, relative control did metastasize. Clinical outcome studies were conducted on training set 103 CRCs validation 220...
Abstract Background The aim of this study was to investigate the association survivin expression with metastasis colorectal cancer (CRC). Methods RT‐PCR and Western blot assays were performed detect in CRC cells normal intestinal epithelial cell. gene also detected 15 tissues, surrounding adjacent colon tissues. Moreover, 48 tissues or without lymph node analyzed. Multivariate analysis for using logistic regression model. RNA interference used inhibit analyze its effect on invasion cells....
Epigenetic mechanisms play a key role in non-targeted effects of radiation. The purpose this study was to investigate global hypomethylation and promoter hypermethylation particular genes induced by low dose radiation (LDR). Thirty male BALB/c mice were divided into 3 groups: control, acutely exposed (0.5Gy X-rays), chronic exposure for 10 days (0.05Gy/d×10d). High-performance liquid chromatography (HPLC) MeDIP-quantitative polymerase chain reaction (qPCR) used methylation profiles. DNMT1...
To investigate the role and mechanism of catalpol on neuroprotective effects memory enhancing simultaneously, were assessed by neurological deficits score, TTC staining, cerebral blood flow detecting. Morris water maze was employed to its learning then clarify possible mechanisms relating central cholinergic system BDNF. Edaravone oxiracetam used for positive control drugs based different action. Results showed that edaravone significantly facilitated function recovery, reduced infarction...
Previous gene transfection studies have shown that the accumulation of human ribonucleotide reductase small subunit M2 (hRRM2) enhances cellular transformation, tumorigenesis, and malignancy potential. The latest identified p53R2 has 80% homology to hRRM2. Here, we investigate role in cancer invasion metastasis.The immunohistochemistry was conducted on a tissue array including 49 primary 59 metastatic colon adenocarcinoma samples determine relationship between expression metastasis. A...
Abstract p53R2, which is one of the two known ribonucleotide reductase small subunits (the other being M2), suggested to play an important role in supplying deoxynucleotide triphosphates (dNTP) for DNA repair during G1 or G2 phase cell cycle. The ability p53R2 supply dNTPs repairing damages requires presence a functional p53 tumor suppressor. Here, we report vivo physical interaction and colocalization p21 before damage. Mammalian two-hybrid assay further indicates that amino acids 1 113 are...
RRM2B is the DNA damage-inducible small subunit of ribonucleotide reductase, rate-limiting enzyme in de novo deoxyribonucleoside triphosphate synthesis. Although implicated repair and maintenance mitochondrial content, regulation function senescence have not been previously established. Here, we show that highly induced a p53-dependent manner during primary human fibroblast IMR90 cells expressed at higher levels senescent precancerous prostatic intraepithelial neoplasm lesions compared to...
Glypican-3 (GPC3) protein expression was determined by immunohistochemical analysis from 29 normal livers, 80 cirrhotic livers sample taken near hepatocellular carcinoma (HCC), and 87 without HCC. The levels for miR-657 HCC-related gene mRNAs were quantitative real-time polymerase chain reaction (qRT-PCR). Also, a published microarray dataset used set enrichment (GSEA) to investigate the relationship between GPC3- signatures. Kaplan–Meier evaluate GPC3 HCC recurrence. not detected in any of...
Hollow mesoporous carbon nanospheres were able to achieve high drug loading, excellent photoacoustic imaging ability and photothermal conversion efficacy, enabling imaging-guided light-activated synergistic therapy.