[structure: see text] This paper describes the cyclotrimerization reaction of di(2-azulenyl)acetylenes (2a,b) catalyzed by Co2(CO)8 to produce hexa(2-azulenyl)benzene derivatives (1a,b). The cyclooligomerization 2a and 2b utilizing CpCo(CO)2 as a catalyst produced (eta5-cyclopentadienyl)[tetra(2-azulenyl)cyclobutadiene]cobalt complexes (3a,b). redox behavior hexakis(6-octyl-2-azulenyl)benzene (1b), bis(6-octyl-2-azulenyl)acetylene (2b), cobalt 3a 3b along with 6-octyl-2-phenylazulene (19)...

Several azulene-substituted thioketones, 1-thiobenzoylazulene (1a) and di(1-azulenyl) thioketone (2a) their derivatives (1b 2b−d) with alkyl substituents on each azulene ring, were prepared intramolecular pericyclization reaction was examined. The thioketones a 3-alkyl substituent ring exhibited the presumed under thermal acid-catalyzed conditions, although cases of 1-azulenyl without afforded complex mixture similar conditions. following hydrogen transfer products 13b, 14b, 14c. 13b 14b...

Tryptanthrin (T) and 13 of its derivatives (T2NH 2 , T2Cl, T2Br, T2NO T8OMe, T8Me, T8F, T8Br, T8NO T2NH 8OMe, 8NO T2Br8Br, ) were synthesized, their antimicrobial activities against a gram-positive bacterium (methicillin-resistant Staphylococcus aureus, MRSA) fungus (Malassezia furfur) investigated.The antibacterial antifungal influenced by the substituents on tryptanthrin, with halogen-substituted tryptanthrin (T2Cl, T2Br8Br) showing highest potency MRSA M. furfur.

Tryptanthrin (T) and eight of its monosubstituted derivatives (T2NH2, T2Cl, T2Br, T2NO2, T8OMe, T8Me, T8F, T8Br) were synthesized, their antimicrobial activities investigated against a fungus (Malassezia furfur) gram-positive bacterium (methicillin-resistant staphylococcus aureus, MRSA). Antimicrobial these influenced by the substituents on tryptanthrin, with halogen-substituted tryptanthrin (T2Cl, showing highest potency M. furfur MRSA. Therefore, semiempirical molecular orbital...

N,N-Di(6-azulenyl)-p-toluidine (1a) and N,N,N',N'-tetra(6-azulenyl)-p-phenylenediamine (2a) their derivatives with 1,3-bis(ethoxycarbonyl) substituents on each 6-azulenyl group (1b 2b) were prepared by Pd-catalyzed amine azulenylation characterized as a study into new aromatic amines for multistage amphoteric redox materials. The behavior of compound was cyclic voltammetry. These compounds undergo facile reduction to stable anion radicals dianion diradicals owing the resonance stabilization...

Abstract Enediyne scaffolds connected by a 9,10‐anthracenediyl spacer as redox‐active substructure with 6‐azulenyl groups π‐electron‐accepting in their periphery ( 3a and 3b ) have been prepared one‐pot reaction involving repeated Pd‐catalyzed alkynylation of 6‐haloazulenes 7b 7c bis(enediyne) derivative 6 . The azulene‐substituted bis(enediyne)s exhibited two reversible one‐step, two‐electron reduction properties upon cyclic voltammetry (CV) attributable to the formation dianionic...

Tryptanthrin derivatives, which are known antimicrobial agents, were synthesized, and their absorption fluorescence spectral behaviors investigated. Our results showed that 2-aminotryptanthrin exhibits both a high quantum yield large positive fluorescent solvatochromism.

This paper describes the preparation of two tetracations 4a(4+) and 4b(4+) composed di(1-azulenyl)methylium units based on a new structural principle cyanine-cyanine hybrid for design electrochromic materials with color changes. Di- monocations 5a(2+), 5b(2+) 6a+, 6b+ were also prepared purpose comparison. The pKR+ values are rather high despite their tetracationic structure, although stability these cations decreases increase number existing cation units. cyclic voltammetry (CV) revealed...

We assayed biologically significant isoprenoids for antibacterial and antifungal activities. Isoprenoids varied widely with respect to their growth inhibitory activities towards Gram-positive Gram-negative bacteria fungal species. Of particular interest was the finding that geraniol acted as a broad spectrum of antibiotic, significantly inhibited Staphylococcus aureus 209P methicillin resistant S. 834, Escherichia coli IFO-3806, Shigella sonnei, well fungus Trichopyton sp. Farnesol strains...

Enhancement of cardiac differentiation is critical to stem cell transplantation therapy for severe ischemic heart disease. The aim this study was investigate whether several derivatives tryptanthrin (1), extracted from the medicinal plant Polygonum tinctorium, induce P19CL6 mouse embryonal carcinoma cells into beating cardiomyocyte-like cells. were cultured in α-MEM supplemented with 10% FBS including a test compound or vehicle. Drug-induced assessed by measuring number and nonbeating...

We previously reported that 2-aminotryptanthrin (T2NH2) possesses excellent photophysical properties such as wide-wavelength absorption and emission in the visible region a high fluorescence quantum yield. It also exhibits large positive fluorescent solvatochromism. In this study, we synthesized 2-(N,N-dimethylamino)tryptanthrin (T2NMe2), from which expected substantial bathochromic shift of band to near-infrared (NIR) by acceleration intramolecular charge transfer. As such, maxima (λf, max)...

2-Hydroxytryptanthrin (T2OH) and its sodium salt (sodium tryptanthrin-2-olate, T2ONa) were synthesized as nearinfrared (NIR) dyes for fluorescent imaging. The absorption maxima (λa,max) of T2OH under a pH range from 1.3 to 7.2 8.5 10.6 ca. 410 nm 495 nm, respectively. Moreover, the fluorescence (λf,max) 660 regardless range. T2ONa was water soluble λf,max in both aprotic protic solvents.

1-(2-tryptanthrinylaminoacetoxy)-14-(1-pyrenecarboxy)-3,6,9,12-tetraoxatetradecane (T2NH-P5P) was synthesized as a fluorescent chemosensor for metal ions. We investigated the metal-ion recognition of T2NH-P5P by separately adding Mg2+, Ca2+, Ba2+, Fe2+, Fe3+, Co2+, Ni2+, Cu2+, Ag+, Zn2+, Cd2+, Hg2+, Al3+, and Pb2+ in an acetonitrile solution. When using excitation at 325 nm, which corresponds to absorption pyrene unit T2NH-P5P, emission 600 from 2-aminotryptanthrin unit, observed, indicating...

A highly flexible carbon nanohoop composed of HBC panels was prepared by connection together with biphenylene spacers.

Preparation of cyclic polyphenylene array 2, which corresponds to a complete carbon zigzag-type CNT segment with (18,0)-structure, has been established by Diels-Alder reaction biphenylylene-acetylene derivative 1 tetraphenylcyclopentadienone. The 2 excess FeCl3 realized presumed cyclodehydrogenation and elimination the alkyl chains that were introduced as measure counter low solubility problem, but this resulted in formation complicated mixture included mass region (18,0)-structure. rather...

2-Hydroxy-1-tryptanthrin (T2OH) and 1-formyl-2-hydroxytryptanthrin (T2OH1CHO) were synthesized as fluorescent metal-ion sensors near-infrared labeling reagents. T2OH was well suited for use a chemosensor Cu2+ Al3+ in an acetonitrile solution, (λf, max > 650 nm) reagent. However, it unable to detect changes surrounding aqueous environment (DMSO/H2O = 1/9, v/v). Meanwhile, T2OH1CHO solutions.