A5000261772- RNA modifications and cancer
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Radio Frequency Integrated Circuit Design
- Civil and Geotechnical Engineering Research
- Advancements in PLL and VCO Technologies
- Simulation and Modeling Applications
- Genetics, Aging, and Longevity in Model Organisms
- RNA Research and Splicing
- Higher Education and Teaching Methods
- Bioinformatics and Genomic Networks
- Industrial Technology and Control Systems
- Galectins and Cancer Biology
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- Viral Infections and Vectors
- Global Trade and Competitiveness
- Structural Engineering and Vibration Analysis
- Traditional Chinese Medicine Studies
- Cytokine Signaling Pathways and Interactions
- Primate Behavior and Ecology
- Electromagnetic Compatibility and Noise Suppression
- Geomechanics and Mining Engineering
Tel Aviv University
2021-2024
AstraZeneca (Brazil)
2023
Kymab (United Kingdom)
2020-2023
AstraZeneca (United Kingdom)
2023
Sanofi (United Kingdom)
2023
Hebrew University of Jerusalem
2021-2022
Indiana University – Purdue University Indianapolis
2019
Takeda (United States)
2019
Taiwan Semiconductor Manufacturing Company (Taiwan)
2015-2018
The Gurdon Institute
2018
Abstract Wildlife must adapt to human presence survive in the Anthropocene, so it is critical understand species responses humans different contexts. We used camera trapping as a lens view mammal changes activity during COVID-19 pandemic. Across 163 sampled 102 projects around world, amount and timing of animal varied widely. Under higher activity, mammals were less active undeveloped areas but unexpectedly more developed while exhibiting greater nocturnality. Carnivores most sensitive,...
KRAS is one of the most frequently mutated human oncogenes. In some settings, oncogenic can trigger cellular senescence, whereas in others it produces hyperproliferation. Elucidating mechanisms regulating these 2 drastically distinct outcomes would help identify novel therapeutic approaches RAS-driven cancers. Using a combination functional genomics and mouse genetics, we identified role for transcription factor Wilms tumor 1 (WT1) as critical regulator senescence proliferation downstream...
An essential step for understanding the transcriptional circuits that control development and physiology is global identification characterization of regulatory elements. Here, we present first map elements across ageing an animal, identifying 42,245 accessible in at least one Caenorhabditis elegans stage. Based on nuclear transcription profiles, define 15,714 protein-coding promoters 19,231 putative enhancers, find both types element can drive orientation-independent transcription....
Chromosomal translocation that results in fusion of the genes encoding RNA-binding protein EWS and transcription factor FLI1 (EWS-FLI1) is pathognomonic for Ewing sarcoma. EWS-FLI1 alters gene expression through mechanisms are not completely understood. We performed RNA sequencing (RNAseq) analysis on primary pediatric human mesenchymal progenitor cells (pMPCs) expressing order to identify targets this oncoprotein. determined long noncoding RNA-277 (Ewing sarcoma–associated transcript 1...
We propose a new architecture of an all-digital PLL (ADPLL) for advanced cellular radios that is optimized 28 nm CMOS. It based on wide tuning range, fine-resolution class-F DCO with only switchable metal capacitors and phase-predictive TDC. The 8mW emits −157 dBc/Hz at 20MHz offset ∼2 GHz, while fully satisfying density rules. 0.4mW TDC clocked 40MHz achieves PVT-stabilized 6 ps resolution −108 in-band phase noise. FREF spur ultra-low <−94 dBc. ADPLL supports 2-point modulation consumes...
We present a new ultra-low-power (ULP) transceiver for Internet-of-Things (IoT) optimized 28-nm CMOS. The receiver (RX) employs high-rate (up to 10 GS/s) discrete-time (DT) architecture with intermediate frequency (IF) placed beyond the 1/f noise corner of MOS devices. New multistage multi-rate charge-sharing bandpass filters are adapted achieve high out-of-band linearity, low and power consumption. A transmitter (TX) an all-digital PLL (ADPLL) switched-current-source digitally controlled...
Gene therapy trials have traditionally used tumor and tissue biopsies for assessing the efficacy of gene transfer. Noninvasive imaging techniques offer a distinct advantage over in that magnitude duration transfer can be monitored repeatedly. Human somatostatin receptor subtype 2 (SSTR2) has been nuclear To extend this concept, we developed receptor-enhanced green fluorescent protein fusion construct (SSTR2-EGFP) multimodality imaging.An adenovirus containing SSTR2-EGFP (AdSSTR2-EGFP) was...
Abstract Amlitelimab (SAR445229), a fully human non-depleting, non-cytotoxic, monoclonal antibody, binds to OX40Ligand (OX40L) on antigen-presenting cells (APC) block OX40-OX40L interactions. In 16-week, double-blind, Phase 2a trial (NCT03754309), amlitelimab induced clinically meaningful disease activity improvement in patients with moderate-to-severe atopic dermatitis (AD). To assess the effects of interleukin (IL)-13 and T-cell recall responses. trial, 89 were randomized low dose (LD; 200...
This paper proposes an ultra-low-voltage (ULV) fractional-N all-digital PLL (ADPLL) powered from a single 0.5 V supply. While its DCO runs directly at V, switched-capacitor DC-DC converter doubles the supply voltage to all digital circuitry and regulates TDC stabilize resolution thus maintaining fixed inband phase noise (PN) across PVT. The ADPLL supports 2-point modulation forms Bluetooth LE (BLE) transmitter realized in 28 nm CMOS. It achieves in-band PN of -106 dBc/Hz (FoM -239.2 dB) RMS...
We propose a new transmitter (TX) architecture for ultra-low power radios. An all-digital PLL employs digitally controlled oscillator with switching current sources to reduce supply voltage and without sacrificing its phase noise startup margins. It also reduces 1/f allowing the ADPLL, after settling, sampling rate or shut it off entirely during direct DCO data modulation. The amplifier integrates matching network while operating in class-E/F <sub...
An integration of 28 nm CMOS RF system with 3D solenoidal inductors (3DSI) in integrated fan-out (InFO) wafer level package technology is studied. The 3DSI provides the performance Q-factor 51 and isolation −53 dB. With 3DSI, InFO results power saving by 58% noise reduction 80% LNA VCO, respectively, compared those SoC system. a novel solution for integration.
RNA polymerase transcription initiation sites are largely unknown in C. elegans. The initial 5’ end of most protein-coding transcripts removed by trans-splicing, and non-coding have not been investigated. We characterized the global landscape Pol II initiation, identifying 73,500 distinct clusters many which bidirectional. assign to 7691 genes find that units show a range patterns differences core promoter elements nucleosome positioning. also HOT (high-occupancy target) regions bound...
In this paper, we investigate an impact of voltage supply scaling on power consumption and performance a new class wireless receivers (RX) for Internet-of-Things (IoT) applications: discrete-time (DT) superheterodyne architecture realized in nanoscale CMOS using inverter-based <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\mathbf{g}_{\mathrm{m}}$</tex> switched capacitors. The is partitioned into three separate domains: RF, intermediate...
Camouflage is a common trait enabling animals to avoid detection by predators and prey. Patterns such as spots stripes are convergent across carnivore families, including felids, hypothesized have adaptive value through camouflage. House cats (Felis catus) were domesticated thousands of years ago, but despite artificial selection for wide variety coat colors, the wild-type pattern tabby very common. We aimed determine whether this grants an advantage over other morphs in natural...
We propose a new approach to an on-chip clock distribution scheme. It is based on distributed multi-GHz LC-tank oscillators generating local clocks. The are mutually coupled align their frequencies and further subharmonically injection-locked much lower frequency reference phases. final phase calibration via adjusting self-resonant frequencies. demonstrate the scheme with two 4GHz digitally controlled (DCO) separated by 650um 16nm CMOS die, differential transmission line 125MHz reference....
As a result of excessive construction and development, the earth environment has severely deteriorated. Based on data from Architecture Building Research Institute, Ministry Interior, amount CO2 emissions industry exceeded one quarter national total. The emission distribution is 9.31% for building materials production, 0.2% construction, 1.49% transportation, 11.88% residential daily energy use 5.94% commercial with total 28.82%. It can be seen that buildings play key role saving reduction...
High Speed Rail significantly saves transportation time between cities in which a stable slab track is an essential and important component. This article introduces the quality management on production of precast tracks system, can act as reference application for concrete industry Taiwan. Case study used to investigate major content this project includes management, organizational structure, material process inventory management. Some other key factors are discussed assure success Taiwan...
Abstract An essential step for understanding the transcriptional circuits that control development and physiology is global identification characterization of regulatory elements. Here we present first map elements across ageing an animal, identifying 42,245 accessible in at least one C. elegans stage. Based on nuclear transcription profiles, define 15,714 protein-coding promoters 19,231 putative enhancers, find both types element can drive orientation-independent transcription....