A5047851245- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Congenital Diaphragmatic Hernia Studies
- Erythropoietin and Anemia Treatment
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Lung Cancer Research Studies
- Intestinal and Peritoneal Adhesions
- Peptidase Inhibition and Analysis
- Nutrition and Health in Aging
- Liver Disease Diagnosis and Treatment
- Folate and B Vitamins Research
- Cardiac, Anesthesia and Surgical Outcomes
- Uterine Myomas and Treatments
- Pulsed Power Technology Applications
- Heat shock proteins research
- Neonatal Respiratory Health Research
- Fungal and yeast genetics research
- Sepsis Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Fungal Biology and Applications
Cornell University
2022-2024
Weill Cornell Medicine
2022-2024
Presbyterian Hospital
2024
Hospital of the University of Pennsylvania
2017-2021
University of Pennsylvania
2017-2020
Sydney Children's Hospital
2018
Memorial Sloan Kettering Cancer Center
2018
McGill University Health Centre
2016
Rosalind Franklin University of Medicine and Science
2012-2014
Boston University
2013
A dominant ataxia among four families of the Arnhem Land Aboriginal people Northern Australia has many clinical features in common with Machado-Joseph disease. Neuropathology on one case showed multiple system involvement, sparing inferior olives and cerebellar cortex, consistent Portuguese ancestry is possible, although not proven.
Pulsed electric field (PEF) ablation utilizes nonthermal energy to disrupt cell membrane integrity and cellular homeostasis. Preclinical data suggests that the absence of thermal damage allows for release intact tumor-associated antigens, inciting a widespread immune response. This therapy could thus have potential both treat target tumors directly distant lesions through abscopal effects. The purpose this study is describe our early experience with pulsed ablation, specifically safety...
Four kindreds of east Arnhem Land Australian aboriginal people from Groote Eylandt and adjacent communities display symptoms a similar spinocerebellar degeneration (multiple-system degenerative disease). The familial pattern indicates an autosomal dominant inheritance, though with varying penetrance in different families. This condition is clinically pathologically consistent Machado-Joseph disease (MJD), there the possibility Portuguese ancestry. These families exhibit anticipation,...
Schizosaccharomyces pombe detects extracellular glucose via a G protein-mediated cyclic AMP (cAMP)-signaling pathway activating protein kinase A (PKA) and regulating transcription of genes involved in metabolism sexual development. In this pathway, Gpa2 Gα binds to activates adenylyl cyclase response detection by the Git3 protein-coupled receptor. Using two-hybrid screen identify extrinsic regulators Gpa2, we isolated clone that expresses codons 471 696 Sck1 kinase, which appears display...
Objective To determine whether erythropoietin given during hemorrhagic shock (HS) ameliorates organ injury while improving resuscitation and survival. Methods Three series of 24 pigs each were studied. In an initial series, 50% the blood volume (BV) was removed in 30 minutes normal saline (threefold removed) started at minute 90 infusing third 30, 60, 150 with shed reinfused 330 (HS-50BV). a second same HS-50BV protocol used but removing additional 15% BV from to 60 (HS-65BV). final as...
Hepatocellular Carcinoma (HCC) is the most common primary liver carcinoma, accounting for 75–85% of all cases. For patients with advanced unresectable and/or metastatic HCC, treatment options primarily include immunotherapy combinations oral tyrosine kinase inhibitors. alpha-fetoprotein (AFP) levels above 400 ng/ml, ramucirumab, an anti-VEGF agent, also approved in second-line setting. However, none these therapies are based on a specific molecular marker and role testing limited. In fact,...
Background Liver-directed therapy (LDT) for hepatocellular carcinoma (HCC) carries a risk of serious liver toxicity, but the is not accurately predicted. Our aim to evaluate baseline and change in function after LDT measured by potentially more sensitive test than usual clinical assessment. Methods We conducted prospective cohort study patients undergoing HCC. evaluated cholate clearance at (T0) 4-10 weeks (T1) 11 patients. Hepatotoxicity was defined as development new complication cirrhosis...
Management of small renal masses (SRMs) with ablation is increasing. Microwave (MWA) newer technology that may have advantages compared to other thermal techniques, including decreased time and heat sink effect. Oncologic outcomes for biopsy-proven cell carcinoma (RCC) patients treated CT-guided MWA are reported. SRMs undergoing percutaneous microwave from 2015-2022 were retrospectively reviewed clinical, pathologic, radiologic, oncologic data after institutional review board approval....
Background Cholangiocarcinoma—with a growing incidence rate and poor prognosis—is not an uncommon cancer. Molecular profiling can reveal actionable aberrations in at least third of the tumors. This is especially so case intrahepatic cholangiocarcinoma (ICC), where mutations isocitrate dehydrogenase 1 2 genes ( IDH1/2) make up 15%–20% these IDH1/2 mutant ICC rare disease that has been adequately reported. To expand spectrum findings seen patients, we present single institution series. Methods...
Introduction: Immune thrombocytopenia (ITP) secondary to durvalumab, a programmed cell death ligand 1 inhibitor, is rare but clinically significant immune-related adverse event. Herein, we present 2 patients with cholangiocarcinoma who developed ITP immediately post-yttrium-90 radioembolization (Y90-RE) while on durvalumab-based systemic therapy. We hypothesize that given the timing, immunotherapy and combination led this It not uncommon approval of its role in locoregional therapies, are...
Abdominal surgery induces mesothelial hypoxia and inflammation, both implicated in the dysregulation of peritoneal fibrinolytic system intraabdominal adhesion formation. Our objective examined contribution each using cultured HMCs. Cells were treated with either a cytokine (C) cocktail (TGFβ+IL‐1β+IFN‐γ), mimetic dimethyloxaloylglycine (D) or both, expression tPA PAI‐1 mRNA was measured at 1, 3, 6, 12, 18 hours (n=4/group) by RT‐PCR. C alone C+D increased levels 6 hr (2.4±0.1 fold;...
Abdominal surgery induces mesothelial injury and the extravasation of a fibrinous exudate into peritoneum. The ensuing deposition fibrin matrix serves as precursor to adhesions. Our aim was determine mechanism(s) by which injury‐induced hypoxia and/or inflammation contribute formation matrix, Cultured HMCs were treated with either an inflammatory cytokine cocktail TGFβ+IL‐1β+IFN‐γ (C), mimetic dimethyloxaloglycine (D) or both, mRNA levels for vascular endothelial growth factor (VEGF;...