A5026091212- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Acute Myocardial Infarction Research
- Transplantation: Methods and Outcomes
- Xenotransplantation and immune response
- Cardiac tumors and thrombi
- ECG Monitoring and Analysis
- Radiation Dose and Imaging
- Cardiovascular Syncope and Autonomic Disorders
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Cardiovascular and Diving-Related Complications
- Cardiovascular Disease and Adiposity
- Cardiovascular Issues in Pregnancy
- IL-33, ST2, and ILC Pathways
- Cardiac Ischemia and Reperfusion
University of Maryland, Baltimore
2015-2024
University of Pennsylvania
1999-2024
University of Maryland Medical Center
2012-2023
Johns Hopkins Hospital
2023
Baptist Memorial Hospital
2023
National Kidney Foundation Singapore
2023
Assiut University
2021
Inova Fairfax Hospital
2018
National University of Singapore
2016-2017
University of Baltimore
2015
Background— Innervation is a critical component of arrhythmogenesis and may present an important trigger/substrate modifier not used in current ventricular tachycardia (VT) ablation strategies. Methods Results— Fifteen patients referred for ischemic VT underwent preprocedural cardiac 123 I- meta -iodobenzylguanidine ( m IBG) imaging, which was to create 3-dimensional (3D) innervation models registered high-density voltage maps. 3D IBG maps demonstrated areas complete denervation transition...
Background Cardiac magnetic resonance imaging (CMRI) is the gold standard for myocardial scar evaluation. Although ideal substrate assessment in ventricular tachycardia (VT), most patients have an implantable cardioverter‐defibrillator (ICD) at presentation ablation. This study evaluates ICD artifact burden during late gadolinium enhancement CMRI (LGE‐CMRI) evaluation of VT with ICDs. Methods Thirty‐one and cardiomyopathy underwent LGE‐CMRI using 1.5‐T scanner before Using American Heart...
Background— Atrial arrhythmias (AAs) including atrial fibrillation (AF) and tachycardia (AT) are often observed after cardiothoracic surgery. Our aim was to evaluate the prevalence mechanism of AAs lung transplantation. Methods Results— All patients (n=127) bilateral sequential transplantation followed at our institution over 20 years were included. received postoperative rhythm monitoring clinic visits with ECG 1, 3, 6, 12 months, or as needed. occurred in 40 127 (31.5%) 4.2�4.1 years. AA...
Background Intracardiac echocardiography (ICE) is increasingly used to guide complex ablation procedures. This study aimed assess the scar substrate of ventricular tachycardia (VT) by ICE in patients undergoing VT ablation. Methods In 22 (10 ischemic, 12 nonischemic), Biosense CARTOSOUND module (Biosense Webster, Diamond Bar, CA, USA) was for three‐dimensional reconstruction ventricles. The characteristics and appearance with imaging voltage‐defined zones (bipolar voltage <0.5 mV), border...
Background Stratifying patients according to 15‐day readmission risk would be useful in identifying those who may benefit from targeted interventions during and/or following hospital discharge that are designed reduce the likelihood of readmission. Methods A prediction model was derived via a case–control analysis discharged tertiary Singapore using multivariate logistic regression. The validated two independent external cohorts separated temporally and geographically. Model discrimination...
Cardiac innervation is a critical component of ventricular arrhythmogenesis that can be noninvasively assessed with <sup>123</sup>I-MIBG. However, the effect tachycardia (VT) ablation on global and regional left sympathetic clinical outcomes has not been previously assessed. <b>Methods:</b> In this prospective, single-center feasibility study, 13 patients cardiomyopathy (<i>n</i> = 9 ischemic, <i>n</i> 4 nonischemic) who were scheduled to undergo drug-refractory VT underwent 15-min 4-h...
Closure of interatrial septal defects with percutaneous devices is increasingly common. However, the indications for closure and techniques device implantation are diverse. We reviewed our first 100 consecutive implants to assess compare indications, results, complications, evolution patent foramen ovale (PFO) atrial defect (ASD) closure. The mean age patients was 52 years 70% were female. Paradoxical embolism predominant indication (94%) PFO significant left-to-right shunt most frequent...
Postischemic adaptation results in characteristic myocardial structural and functional changes the ventricular tachycardia (VT) substrate.The aim of this study was to compare adaptations (late gadolinium enhancement/abnormal innervation) with detailed VT mapping data identify regional heterogeneities postischemic changes.Methods: Fifteen patients ischemic cardiomyopathy drug-refractory underwent late enhancement cardiac MRI (CMR), 123 I-metaiodobenzylguanidine SPECT, high-resolution bipolar...
Visualization of left atrial (LA) anatomy using image integration modules has been associated with decreased radiation exposure and improved procedural outcome when used for guidance pulmonary vein isolation (PVI) in fibrillation (AF) ablation. We evaluated the CARTOSEG™ CT Segmentation Module (Biosense Webster, Inc.) that offers a new CT-specific semiautomatic reconstruction endocardium.The software was assessed prospectively 80 patients undergoing AF Using preprocedural contrast-enhanced...
Abstract Background Cardiac magnetic resonance (CMR) characteristics of ventricular radiofrequency ablation (RFA) lesions have only been incompletely defined. Aim To determine the detectability and imaging RFA in an unselected patient cohort undergoing arrhythmia ablation. Methods results A retrospective chart review (n = 249) identified 36 patients with either pre‐/postablation CMR 14) or postablation 22). Ablation could be 50% 18) patients. Nonvisualized had more preexisting transmural...
In population-based research exome sequencing, the path from variant discovery to return of results is not well established. Variants discovered by sequencing have potential improve population health.Population-based and agnostic ExWAS were performed 5521 Amish individuals. Additional phenotyping in vitro studies enabled reclassification a KCNQ1 unknown significance pathogenic. Results returned participants community setting.A missense was identified (c.671C>T, p.T224M), gene associated with...