A5003608538- Testicular diseases and treatments
- Sexual Differentiation and Disorders
- Urologic and reproductive health conditions
- Ovarian cancer diagnosis and treatment
- Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Lung Cancer Research Studies
- Sperm and Testicular Function
- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hormonal and reproductive studies
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Chemotherapy-induced organ toxicity mitigation
- Lung Cancer Treatments and Mutations
- Epilepsy research and treatment
- Male Reproductive Health Studies
- Chronic Kidney Disease and Diabetes
- Urological Disorders and Treatments
- Colorectal and Anal Carcinomas
- Statistical Methods in Clinical Trials
- Genital Health and Disease
- Pharmacological Effects and Toxicity Studies
Copenhagen University Hospital
2013-2017
Rigshospitalet
2011-2017
Danish Cancer Society
2015-2016
Aarhus University Hospital
2014-2015
Odense University Hospital
2014-2015
Technical University of Denmark
2015
Filadelfia
2010
To describe treatment results in a large cohort with stage I nonseminoma germ cell cancer (NSGCC) treated surveillance program.From January 1, 1984, to December 31, 2007, 1,226 patients NSGCC, including high-risk vascular invasion, were observed program.The relapse rate after orchiectomy alone was 30.6% at 5 years. Presence of invasion together embryonal carcinoma and rete testis the testicular primary identified group risk 50%. Without factors, 12%. Eighty percent relapses diagnosed within...
Patients given systemic treatment for testicular germ cell cancer (GCC) are at increased risk a second malignant neoplasm (SMN). Previous studies on SMN and causes of death lacked information the exact applied or were based patients receiving former options.To evaluate treatment-specific risks in nationwide population-based cohort with GCC treated current standard regimens.This study examined Danish 5190 men who entered Testicular Cancer database between January 1, 1984, December 31, 2007....
For patients with germ cell cancer, various pulmonary toxicity risk factors have been hypothesized for treatment bleomycin, etoposide, and cisplatin (BEP). Because existing studies shortcomings, we present a large, unselected cohort of who undergone close monitoring lung function before, during, after BEP to disclose valid factors.All were treated at Rigshospitalet, Copenhagen, Denmark, from 1984 2007, included. Pulmonary tests (PFTs) that measured the diffusing capacity lungs carbon...
BACKGROUND The optimal treatment strategy for patients with clinical stage I (CS‐1) seminoma is controversial. objective of the current study was to evaluate outcomes considered be at high risk disease recurrence a tumor size ≥6 cm. Patients were treated either adjuvant radiotherapy (RT) or followed surveillance. METHODS From Danish Testicular Cancer database, authors identified 473 CS‐1 Of these, 254 underwent RT and 219 Cumulative incidence function applied estimate recurrence, second...
Purpose A small number of patients with germ cell cancer (GCC) receive more than one line treatment for disseminated disease. The purpose this study was to evaluate late toxicity and survival in an unselected cohort who experienced relapse after receiving first-line Methods From the Danish Testicular Cancer database, we identified all received Information about mortality obtained by means linkage national registers. Prognostic factors death were compared International Factors Study Group...
Estimates of glomerular filtration rate (eGFR) are widely used when administering nephrotoxic chemotherapy. No studies performed in oncology patients have shown whether eGFR can safely substitute a measured GFR (mGFR) based on marker method. We aimed to assess the validity four major formulas PCr (Cockcroft-Gault, MDRD, Wright and CKD-EPI) comparison mGFR an setting. Patients included had disseminated germ cell cancer received conventional chemotherapy: bleomycin, etoposide cisplatin. The...
4502 Background: The standard treatment for stage I seminoma remains a topic discussion. Survival rates are excellent irrespective of modality (radiotherapy, carboplatin or surveillance). However, late effects might differ between options. Only smaller surveillance studies with limited follow-up have previously been published. We present data from large nationwide cohort study on in patients. Methods: A and population based clinical database covering germ cell cancer patients diagnosed...
4533 Background: In 1997 the International Germ Cell Cancer Collaborative Group presented a classification dividing patients into good, intermediate, and poor prognostic group for metastatic GCC with 5-year survival information. However, only minor part of these were treated today’s standard treatment. We present first nationwide population based study overall (OS) disease specific (DSS) in large cohort BEP. Methods: A clinical database covering diagnosed 1984-2007 was constructed, including...
Summary Testicular cancer survivors have impaired gonadal function and increased risk of metabolic syndrome when compared to healthy controls. However, because the fetal etiology testicular cancer, familial unrelated men might not be an optimal control group. The objective this study was clarify if their biological brothers. A cross‐sectional (ClinicalTrials.gov number, NCT 02240966) conducted between 2014 2016. Of 158 included, 24 had a brother who accepted participate in study. Serum...
Objectives. – To assess the medical insurance risk for patients with stage I testicular cancer (TC), by calculating overall mortality and without relapse, compare it to men from Danish population. Background. Testicular is most common malignancy in young males. Outcomes of a cohort 3366 TC (1366 non-seminomas (NSTC) 2000 Seminomas (STC)), were analyzed. Method. The data analyzed “illness-death” model. For analysis transitions between diagnosis, relapse death we adopted parametric approach,...
4533 Background: A small fraction of patients with germ-cell cancer (GCC) receive more than one line systemic treatment. The purpose this study was to evaluate late-toxicity and survival in an unselected cohort who relapsed after initial treatment for disseminated disease. Methods: Based on the Danish DaTeCa database we identified all received two or lines Information late-effects mortality GCC-survivors obtained through linkage national registers. Prognostic factors relapse death were...
Pancreatic cancer continues to be one of the most lethal cancers. It is 7th leading cause in United States and 4th cancer-related death.[1][1] Although pulmonary metastases pancreatic not uncommon, a nonproductive cough as only complaint for