A5055001518- Chronic Lymphocytic Leukemia Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Metabolism, Diabetes, and Cancer
- Immunodeficiency and Autoimmune Disorders
- Single-cell and spatial transcriptomics
- Lymphoma Diagnosis and Treatment
- Mechanisms of cancer metastasis
- Mitochondrial Function and Pathology
- Hepatitis B Virus Studies
- Glycosylation and Glycoproteins Research
- Protein Tyrosine Phosphatases
- Colorectal Cancer Treatments and Studies
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Molecular Biology Techniques and Applications
- PI3K/AKT/mTOR signaling in cancer
- Genomics and Chromatin Dynamics
- Glycogen Storage Diseases and Myoclonus
- Acute Lymphoblastic Leukemia research
- Phagocytosis and Immune Regulation
- Genomics and Phylogenetic Studies
Beckman Research Institute
2022-2024
City of Hope
2018-2024
City Of Hope National Medical Center
2020-2023
Advanced Centre for Treatment, Research and Education in Cancer
2015-2021
Homi Bhabha National Institute
2016-2021
Tata Memorial Hospital
2016-2021
California Library Association
2018
Igenbio (United States)
2016
Cancer Research Institute
2015
RNA splicing factor SF3B1 is recurrently mutated in various cancers, particularly hematologic malignancies. We previously reported that coexpression of Sf3b1 mutation and Atm deletion B cells, but not either lesion alone, leads to the onset chronic lymphocytic leukemia (CLL) with CLL cells harboring chromosome amplification. However, exact role chromosomal instability (CIN) remains unclear. Here, we demonstrated promotes centromeric R-loop (cen-R-loop) accumulation, leading increased...
Human papilloma virus (HPV) accounts for the most common cause of all virus-associated human cancers. Here, we describe first graphic user interface (GUI)-based automated tool 'HPVDetector', non-computational biologists, exclusively detection and annotation HPV genome based on next-generation sequencing data sets. We developed a custom-made reference that comprises chromosomes along with annotated 143 types as pseudochromosomes. The runs dual mode defined by user: 'quick mode' to identify...
We earlier proposed a genetic model for gallbladder carcinogenesis and its dissemination cascade. However, the association of cancer 'inflammatory stimulus' to drive initial cascade in remained unclear. A recent study suggested infection with Salmonella can lead changes host signalling pathways cancer. examined whole exomes 26 primary gall bladder tumour paired normal samples presence 143 HPV (Human papilloma virus) types along 6 common serotypes (S. typhi Ty2, S. CT18, typhimurium LT2,...
Lung cancer is the leading cause of cancer-related deaths across world. In this study, we present therapeutically relevant genetic alterations in lung adenocarcinoma Indian origin.Forty-five primary tumors were sequenced for 676 amplicons using RainDance panel at an average coverage 1500 × (reads per million mapped reads). To validate findings, 49 mutations 23 genes genotyped additional set 363 mass spectrometry. NIH/3T3 cells over expressing mutant and wild-type FGFR3 constructs...
The uncommonness of gallbladder cancer in the developed world has contributed to generally poor understanding disease. Our integrated analysis whole exome sequencing, copy number alterations, immunohistochemical, and phospho‐proteome array profiling indicates ERBB2 alterations 40% early‐stage rare tumors, among an ethnically distinct population not studied before, that occurs through overexpression 24% ( n = 25) recurrent mutations 14% tumors 44); along with co‐occurring KRAS mutation 7%...
Abstract Background Residual disease of glioblastoma (GBM) causes recurrence. However, targeting residual cells has failed, due to their inaccessibility and our lack understanding survival mechanisms radiation therapy. Here we deciphered a cell–specific mechanism essential for GBM relapse. Methods Therapy resistant (RR) were captured from primary patient samples cell line models mimicking clinical scenario resistance. Molecular signaling resistance in RR was identified using RNA sequencing,...
// Asim Joshi 1 , 4 Rohit Mishra Sanket Desai Pratik Chandrani 2 5 Hitesh Kore Roma Sunder Supriya Hait Prajish Iyer Vaishakhi Trivedi Anuradha Choughule Vanita Noronha Amit Vijay Patil Nandini Menon Rajiv Kumar 3 Prabhash and Dutt Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment Research Education in (ACTREC), Tata Memorial Centre, Navi Mumbai, Maharashtra 410210, India Department of Medical Oncology, Ernest Borges Marg, Parel, 400012, Pathology, Homi Bhabha National...
Richter’s transformation (RT) is a progression of chronic lymphocytic leukemia (CLL) to aggressive lymphoma. MGA ( Max gene associated ), functional MYC suppressor, mutated at 3% in CLL and 36% RT. However, genetic models molecular mechanisms deletion that drive RT remain elusive. We established an mouse model by knockout Mga the Sf3b1 / Mdr using CRISPR-Cas9 determine role Murine cells exhibited mitochondrial aberrations with elevated oxidative phosphorylation (OXPHOS). Through RNA...
Cancer is predominantly a somatic disease. A mutant allele present in cancer cell genome considered when it's absent the paired normal along with public SNP databases. The current build of dbSNP, most comprehensive database, however inadequately represents several non-European Caucasian populations, posing limitation genomic analyses data from these populations. We Tata Memorial Centre-SNP database (TMC-SNPdb), as first open source, flexible, upgradable, and freely available (accessible...
Several statistical tools have been developed to identify genes mutated at rates significantly higher than background, indicative of positive selection, involving large sample cohort studies. However, studies smaller sizes are inherently restrictive due their limited power low frequency genetic variations. We performed an integrated characterization copy number, mutation and expression analyses four head neck cancer cell lines - NT8e, OT9, AW13516 AW8507-- by applying a filtering strategy...
Abstract Richter’s transformation (RT) is a progression of chronic lymphocytic leukemia (CLL) to aggressive lymphoma. MGA ( Max gene associated ), functional MYC suppressor, mutated at 3% in CLL and 36% RT. However, genetic models molecular mechanisms deletion driving RT remain elusive. We established novel mouse model by knockout Mga the Sf3b1 / Mdr via CRISPR-Cas9 determine role Murine cells exhibit mitochondrial aberrations with elevated oxidative phosphorylation (OXPHOS). identified Nme1...
Recurrent somatic mutations in spliceosome factor 3b subunit 1 (SF3B1) are identified hematopoietic malignancies, with SF3B1-K700E being the most common one. Here, we show that regulatory T cell (T reg )–specific expression of ( Sf3b1 K700Efl/+ /Foxp3 YFP-Cre ) results spontaneous autoimmune phenotypes. CD4 + cells from mice display defective differentiation and inhibitory function, which is demonstrated by failed prevention adoptive transfer colitis regs . Mechanically, induces an aberrant...
Abstract Several statistical tools have been developed to identify genes mutated at rates significantly higher than the background, indicative of positive selection, involving large sample cohort studies. However, studies relatively smaller sizes or single data-type genome wide analysis are inherently restricted due their limited power low frequency genetic variation. We undertook integrated copy number, mutation and expression analyses head neck cancer cell lines assessing multiple levels...
Liver cancer is one of the sixth most common cancers, a global threat to world health, with 8,41,000 new cases and 782,000 deaths yearly worldwide per GLOBOCAN, 2018.1Bray F. Ferlay J. Soerjomataram I. Siegel R.L. Torre L.A. Jemal A. Global statistics 2018: GLOBOCAN estimates incidence mortality for 36 cancers in 185 countries.CA A Cancer Clin. 2018; 68: 394-424Google Scholar mainly occurs males, 55% are Chinese origin. Hepatocellular carcinoma (HCC) types aggressive liver cancer, accounting...
Abstract Background: Gallbladder cancer is fifth most common cancers among the gastrointestinal with majority of patients presented at an advanced state disease. In India, gallbladder a major problem in northern part country its highest incidence 22/1,00,000 women and risk factors ranging from gallstones, female gender, ethnicity, Salmonella infections genetic alterations. Despite high our country, there only few candidate gene based studies systematic genome-wide are far dismal. Hence unmet...