A5020870549- Metabolomics and Mass Spectrometry Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Mitochondrial Function and Pathology
- Circular RNAs in diseases
- Anesthesia and Neurotoxicity Research
- Biochemical effects in animals
- FOXO transcription factor regulation
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Adenosine and Purinergic Signaling
- Prenatal Screening and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Molecular Biology Techniques and Applications
- Thyroid and Parathyroid Surgery
- Thyroid Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
George Washington University
2012-2021
George Washington University Hospital
2017
Cancer Genetics (United States)
2012
Roswell Park Comprehensive Cancer Center
2012
Tulane University
2012
University at Buffalo, State University of New York
2012
Louisiana State University
2012
Louisiana State University Health Sciences Center New Orleans
2012
During glutaminolysis, glutamine is catabolized to glutamate and incorporated into citric acid cycle lipogenesis. Serum levels were measured in patients with primary prostate cancer or metastatic castrate-resistant (mCRPCa) establish clinical relevance. The effect of deprivation blockade by metabotropic receptor 1 (GRM1) antagonists was investigated on cells' growth, migration, invasion biologic relevance.Serum normal men (n = 60) 197) mCRPCa 109). GRM1 expression prostatic tissues examined...
Triple-negative breast cancer (TNBC) represents 15 to 20% of all types cancer; however, it accounts for a large number metastatic cases and deaths, there is still no effective treatment. The deregulation microRNAs (miRNAs) in has been widely reported. We previously identified that miR-638 was one the most deregulated miRNAs progression. Bioinformatics analysis revealed directly targets BRCA1. aim this study investigate role prognosis treatment.Formalin-fixed, paraffin-embedded (FFPE) samples...
// Xiaohui Tan 1 , Yebo Fu Liang Chen Woojin Lee Yinglei Lai 2 Katayoon Rezaei 3 Sana Tabbara Patricia Latham Christine B. Teal 4 Yan-Gao Man 5 Robert S. Siegel 6 Rachel F. Brem 7 Sidney W. Department of Medicine (Division Genomic Medicine), The George Washington University School and Health Sciences, Washington, DC, USA Statistics, University, Pathology, Surgery, Research Lab International Collaboration, Bon Secours Cancer Institute, System, Richmond, VA, Hematology/Oncology), Radiology,...
Genomic and transcriptome sequencing of bladder cancer (BLCA) has identified multiple molecular alterations during progression. Many these genetic epigenetic changes play a role in the progression this disease. Studies have subtypes muscle-invasive (MIBC) with different sensitivities to frontline therapy suggesting heterogeneity tumors importance characterization MIBC provide effective treatment. Specifically, it become increasingly evident, as demonstrated by The Cancer Genome Atlas...
Understanding the molecular alterations associated with breast cancer (BC) progression may lead to more effective strategies for both prevention and management. The current model of BC suggests a linear, multistep process from normal epithelial atypical ductal hyperplasia (ADH), carcinoma in situ (DCIS), then invasive (IDC). Up 20% ADH 40% DCIS lesions progress if left untreated. Deciphering mechanisms during is therefore crucial prevent over- or under-treatment. Our previous work...
Retinoblastoma (RB) is a children's ocular cancer caused by mutated retinoblastoma 1 (Rb1) gene on both alleles. Rb1 and other related genes could be regulated microRNAs (miRNA) via complementarily pairing with their target sites. MicroRNA-21 (miR-21) possesses the oncogenic potential to several tumor suppressor genes, including PDCD4, regulates progression metastasis. However, mechanism of how miR-21 PDCD4 poorly understood in RB. We investigated expression miRNAs RB cell lines identified...
•There is no consensus on optimal treatment for GTN and brain metastases.•Brain metastasis treated with craniotomy intravenous, EMA-CO chemotherapy•Intravenous high-dose methotrexate may be adequate to treat metastases.
Background. Endoscopic laser-ablative therapy of upper tract urothelial carcinoma offers kidney-sparing treatment for well-selected low-risk tumors. The traditional technique consists tumor biopsy with flexible forceps or nitinol basket pathologic assessment stage and grade, followed by laser ablation the tumor. In this case, we present use new T-1470 LiteTouch™ intraoperative en bloc resection, affording both tissue acquisition ablation. Case Presentation. An 81-year-old female a past...
Abstract microRNA (miRNA) dysfunction is associated with a variety of human diseases including cancer. Our previous study showed that miR-671-5p was deregulated during breast cancer progression. We aim to decipher the functional mechanism in found expression decreased significantly ductal carcinoma situ (DCIS) and invasive (IDC) compared normal atypical hyperplasia (ADH) microdissected formalin-fixed, paraffin-embedded (FFPE) tissues. Forkhead Box M1 (FOXM1), as an oncogenic transcription...
Abstract Triple-negative breast cancer (TNBC) is a subtype of that negative for estrogen and progesterone receptors (ER/PR) human epidermal growth factor receptor 2 (HER2). It typically associated with high rate metastasis limited targeted treatment options. Chemotherapy the standard metastatic TNBC. However, development chemoresistance limits its clinical application. Elevated expression immune-related genes in TNBC suggests immunotherapy strategies may provide new therapeutic options...
You have accessJournal of UrologyBladder Cancer: Invasive II1 Apr 2015MP58-07 TUMOR PD-L1 AND LYMPHOCYTIC INFILTRATE FOXP3 STATUS IN NON-MUSCLE INVASIVE UROTHELIAL CARCINOMA OF BLADDER (NMIBC) Gunes Guner, Maria Angelica Mendoza Rodriguez, Alexander Baras, Jen-Jane Liu, Sheila Friedrich Faraj, Nilda Gonzales-Roibon, Noah M Hahn, Charles Drake, Trinity J. Bivalacqua, Janis Taube, Katayoon Rezaei, and George Netto GunerGunes Guner More articles by this author , RodriguezMaria Rodriguez...
You have accessJournal of UrologyBladder Cancer: Basic Research II1 Apr 2014MP28-10 IGF1R IMMUNOEXPRESSION IN SUPERFICIAL NON-MUSCLE INVASIVE UROTHELIAL CARCINOMA OF URINARY BLADDER Sheila Faraj, Nilda Gonzalez-Roibon, Stephania Bezerra, Enrico Munari, Rajni Sharma, Katayoon Rezaei, Trinity Bivalacqua, Mark Schoenberg, and George Netto FarajSheila Faraj , Gonzalez-RoibonNilda Gonzalez-Roibon BezerraStephania Bezerra MunariEnrico Munari SharmaRajni Sharma RezaeiKatayoon Rezaei...
Abstract Breast cancer progression involves stepwise transition from atypical ductal hyperplasia (ADH), carcinoma in situ (DCIS) to invasive (IDC). Percutaneous core needle biopsy (CNB) is the standard procedure after an abnormal mammography finding. However, a CNB diagnosis with either ADH or DCIS often non-conclusive. A definitive relies on surgical excision for further pathological analysis differentiate simple (sADH) coexisted advanced lesions such as and/or IDC (cADH). Therefore,...
<div>Abstract<p><b>Purpose:</b> During glutaminolysis, glutamine is catabolized to glutamate and incorporated into citric acid cycle lipogenesis. Serum levels were measured in patients with primary prostate cancer or metastatic castrate-resistant (mCRPCa) establish clinical relevance. The effect of deprivation blockade by metabotropic receptor 1 (GRM1) antagonists was investigated on cells' growth, migration, invasion biologic...
<div>Abstract<p><b>Purpose:</b> During glutaminolysis, glutamine is catabolized to glutamate and incorporated into citric acid cycle lipogenesis. Serum levels were measured in patients with primary prostate cancer or metastatic castrate-resistant (mCRPCa) establish clinical relevance. The effect of deprivation blockade by metabotropic receptor 1 (GRM1) antagonists was investigated on cells' growth, migration, invasion biologic...
<p>PDF file - 188K, Scratch-wound migration assays</p>
<p>PDF file - 80K, Immunohistochemical staining of metabotropic glutamate receptor 1 (GRM1) in selected prostate cancers</p>
<p>PDF file - 83K</p>
<p>PDF file - 156K, Comparison of serum glutamate levels in African Americans and Caucasian with metastatic-castrate resistant prostate cancer</p>
<p>PDF file - 61K, Immunohistochemical staining of metabotropic glutamate receptor 1 (GRM1) in selected non-malignant prostatic tissues</p>