Katsushige Kawase
A5018583882- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- interferon and immune responses
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Cancer-related molecular mechanisms research
- Ear and Head Tumors
- Cytomegalovirus and herpesvirus research
- Sarcoma Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Single-cell and spatial transcriptomics
- Molecular Biology Techniques and Applications
- Endometrial and Cervical Cancer Treatments
- Nanoplatforms for cancer theranostics
- Ovarian cancer diagnosis and treatment
- Vascular Tumors and Angiosarcomas
- RNA Research and Splicing
- Brain Metastases and Treatment
- Viral-associated cancers and disorders
- Head and Neck Cancer Studies
- RNA modifications and cancer
Chiba Cancer Center
2021-2025
Chiba University
2018-2024
Immune checkpoint inhibitors exert clinical efficacy against various types of cancer through reinvigoration exhausted CD8+ T cells that attack directly in the tumor microenvironment (TME). Using single-cell sequencing and mouse models, we show CXCL13, highly expressed tumor-infiltrating cells, induces CD4+ follicular helper (TFH) cell infiltration, contributing to anti-tumor immunity. Furthermore, a part TFH TME exhibits cytotoxicity attacks major histocompatibility complex-II-expressing...
Abstract Although transcriptome alteration is an essential driver of carcinogenesis, the effects chromosomal structural alterations on cancer are not yet fully understood. Short-read transcript sequencing has prevented researchers from directly exploring full-length transcripts, forcing them to focus individual splice sites. Here, we develop a pipeline for Multi-Sample long-read Transcriptome Assembly (MuSTA), which enables construction sequence data. Using constructed as reference, analyze...
T-cell exhaustion is a major contributor to immunosuppression in the tumor microenvironment (TME). Blockade of key regulators exhaustion, such as programmed death 1, can reinvigorate tumor-specific T cells and activate antitumor immunity various types cancer. In this study, we identified that CD106 was specifically expressed exhausted CD8+ TME using single-cell RNA sequencing. High expression clinical samples corresponded improved response cancer immunotherapy. suppressed both vitro vivo,...
Loss of heterozygosity (LOH) has been reported to occur in HLA regions cervical intraepithelial neoplasia (CIN) and cancer. However, the details how this is related progression CIN have unclear. In study, we examined human papillomavirus (HPV) antigen-presenting capacity people with significance LOH class I CIN. It was shown that differences among each case depended on types, not HPV genotypes. Focusing type, there a positive correlation between against frequency allelic loss. Furthermore,...
Abstract Background: Immune checkpoint inhibitors (ICIs) exert clinical efficacy against various types of cancer through reinvigoration exhausted CD8+ T cells that attack directly in the tumor microenvironment (TME). However, compared to cell exhaustion, role CD4+ exhaustion antitumor immunity remains unclear. Methods and Results: From single-cell sequencing for tumor-infiltrating lymphocytes (TILs) from patients with melanoma mouse models, we found CXCL13, which is highly expressed cells,...
<div>Abstract<p>T-cell exhaustion is a major contributor to immunosuppression in the tumor microenvironment (TME). Blockade of key regulators T-cell exhaustion, such as programmed death 1, can reinvigorate tumor-specific T cells and activate antitumor immunity various types cancer. In this study, we identified that CD106 was specifically expressed exhausted CD8<sup>+</sup> TME using single-cell RNA sequencing. High expression clinical samples corresponded improved...
<div>Abstract<p>T-cell exhaustion is a major contributor to immunosuppression in the tumor microenvironment (TME). Blockade of key regulators T-cell exhaustion, such as programmed death 1, can reinvigorate tumor-specific T cells and activate antitumor immunity various types cancer. In this study, we identified that CD106 was specifically expressed exhausted CD8<sup>+</sup> TME using single-cell RNA sequencing. High expression clinical samples corresponded improved...
<p>Additional scRNA-seq data</p>
<p>Additional scRNA-seq data</p>
<p>LAG3, HAVCR2, TIGIT, TNFRSF9, ENTPD1, and ITGAE expression using our scRNA-seq data volcano plots (exhausted CD8+ T-cell vs. the others) publicly available datasets</p>
<p>Multiplexed fluorescent immunohistochemistry</p>
<p>Influence of CD106 on various surface molecules</p>
<p>Additional CD106 expression data in PBMCs</p>
<p>LAG3, HAVCR2, TIGIT, TNFRSF9, ENTPD1, and ITGAE expression using our scRNA-seq data volcano plots (exhausted CD8+ T-cell vs. the others) publicly available datasets</p>
<p>Influence of CD106 on various surface molecules</p>
<p>Multiplexed fluorescent immunohistochemistry</p>
<p>Additional CD106 functional analysis data</p>
<p>Sequencing summary</p>
<p>Additional <i>in vivo</i> data.</p>
<p>Patient characteristics for prognostic analyses</p>
<p>Additional CD106 expression data in PBMCs</p>