A5063713131- Glaucoma and retinal disorders
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Intraocular Surgery and Lenses
- Endometriosis Research and Treatment
- Retinal Imaging and Analysis
- Thermoregulation and physiological responses
- Uterine Myomas and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Hepatitis B Virus Studies
- Angiogenesis and VEGF in Cancer
- Optical Imaging and Spectroscopy Techniques
- Corneal surgery and disorders
- Cancer Cells and Metastasis
- Photoreceptor and optogenetics research
- Corneal Surgery and Treatments
- Ophthalmology and Eye Disorders
- Neurological Disorders and Treatments
- Reproductive System and Pregnancy
- Metastasis and carcinoma case studies
- Receptor Mechanisms and Signaling
The University of Tokyo
1987-2024
University of Tokyo Hospital
2023-2024
Toranomon Hospital
2020
Noguchi Hospital
2003-2010
Josai University
2008-2009
University of Washington
2009
// Masakazu Sato 1 , Kei Kawana Katsuyuki Adachi Asaha Fujimoto Mitsuyo Yoshida Hiroe Nakamura Haruka Nishida Tomoko Inoue Ayumi Taguchi Juri Takahashi Satoko Eguchi Aki Yamashita Kensuke Tomio Osamu Wada-Hiraike Katsutoshi Oda Takeshi Nagamatsu Yutaka Osuga Tomoyuki Fujii Department of Obstetrics and Gynecology, Graduate School Medicine, The University Tokyo, Bunkyo-ku, Japan Correspondence to: Kawana, email: kkawana-tky@umin.org Keywords: cancer stem cell (CSC), metabolomics, ovarian...
Cancer-associated fibroblasts (CAFs) play an important role in cancer expansion and progression tumor microenvironment (TME), via both direct indirect interactions. Natural killer (NK) cells a crucial anticancer immunity. We investigated the inhibitory effects of CAFs on NK cell activity. were isolated from endometrial tissue, while normal (NEFs) obtained endometrium with no pathological abnormality. allogenic healthy volunteers. or NEFs co-cultured at NK/fibroblast ratio 1:1 without...
A new ophthalmic electronic videoendoscope system has a 20-guage probe for intraocular observation, standard size vitreous microsurgical instruments, and both endoscopic operating microscopic images are displayed on split-screen monitor to provide surgeos simultaneous view of images. Using this endoscope at any time during surgery, surgeons can examine the structure such as ciliary sulcus, pars plana, or base obtain valuable but otherwise unobtainable information completing surgery.
To measure soluble vascular endothelial growth factor receptor-2 (sVEGFR-2) in the vitreous fluid of patients with central retinal vein occlusion (CRVO) and macular oedema or idiopathic hole, to investigate relation between sVEGFR-2 (VEGF).Vitreous samples were obtained from 44 during vitreoretinal surgery (29 CRVO 15 hole). Then VEGF levels measured by ELISA. Retinal ischaemia was evaluated measuring area capillary nonperfusion on fluorescein angiograms public domain Scion Image program....
Low-grade inflammation, which plays important roles in the development of fatal diseases, is commonly observed obese people. However, this has not been evaluated lean people, who have relatively increased mortality risk compared with people normal weight. Here, we elucidate association between systemic low-grade inflammation and low body weight, particular emphasis on aging. We examined relationship circulating C-reactive protein (CRP) BMI a cross-sectional study 2,675 apparently healthy...
// Hiroe Nakamura 1, * , Ayumi Taguchi Kei Kawana 2 Satoshi Baba 1 Akira Kawata Mitsuyo Yoshida Asaha Fujimoto Juri Ogishima Masakazu Sato Tomoko Inoue Haruka Nishida Hitomi Furuya Aki Yamashita Satoko Eguchi Kensuke Tomio Mayuyo Mori-Uchino Katsuyuki Adachi Takahide Arimoto Osamu Wada-Hiraike Katsutoshi Oda Takeshi Nagamatsu Yutaka Osuga and Tomoyuki Fujii Department of Obstetrics Gynecology, Graduate School Medicine, The University Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan Nihon Itabashiku,...
Cancer cell metabolism is currently considered to be context dependent, and metabolic reprogramming being widely investigated. It known that ovarian cancer often metastasizes the omentum. Given omentum itself contains a high concentration of adipocytes, thought good model for research into (particularly shift lipid metabolism). The present study investigated switch in cells. first possibility epigenetic involvement. Using an open database (GSE 85293 GSE2109), methylation status gene...
In cervical cancer, p53-induced apoptosis is abrogated by human papilloma virus (HPV)-derived oncoprotein E6. Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) provides tumor-specific in various cancers, including the sensitivity differs depending on cell lines. Signal transducer and activator of transcription 3 (STAT3) a hub molecule that shifts cellular fate to or survival response stresses. However, contribution STAT3 activity TRAIL-induced cancer remains unknown....
Cervical intraepithelial neoplasia (CIN) has a natural history of bidirectional transition between different states. Therefore, conventional statistical models assuming unidirectional disease progression may oversimplify CIN fate. We applied continuous-time multistate Markov model to predict this fate by addressing the probability transitions multiple states according genotypes high-risk human papillomavirus (HPV). This retrospective cohort comprised 6022 observations in 737 patients (195...
We present a case of recurrent ovarian cancer at the age 75, gravida 1 para 0, with 18 years disease-free survival. Chemotherapy brought 10-month partial response status; to further improve overall survival, patient was evaluated using AGO score (DESKTOP III trial, 2020), which originally intended for cases immediately after diagnosis recurrence; has indicated significant outcome; went through hepatosplenic metastatic site resection; and complete resection achieved. Subsequently, PARP...
Loss of heterozygosity (LOH) has been reported to occur in HLA regions cervical intraepithelial neoplasia (CIN) and cancer. However, the details how this is related progression CIN have unclear. In study, we examined human papillomavirus (HPV) antigen-presenting capacity people with significance LOH class I CIN. It was shown that differences among each case depended on types, not HPV genotypes. Focusing type, there a positive correlation between against frequency allelic loss. Furthermore,...
// Masakazu Sato 1 , Kei Kawana 2 Katsuyuki Adachi Asaha Fujimoto Mitsuyo Yoshida Hiroe Nakamura Haruka Nishida Tomoko Inoue Ayumi Taguchi Juri Ogishima Satoko Eguchi Aki Yamashita Kensuke Tomio Osamu Wada-Hiraike Katsutoshi Oda Takeshi Nagamatsu Yutaka Osuga and Tomoyuki Fujii Department of Obstetrics Gynecology, Graduate School Medicine, The University Tokyo, Bunkyo-ku, Japan Nihon University, Itabashi-ku, Correspondence to: Kawana, email: kkawana-tky@umin.org Keywords: cancer stem cell...
Ovarian cancer is one of the leading causes death in world, which linked to its resistance chemotherapy. Strategies overcome chemoresistance have been keenly investigated. Culturing cells suspension, results formation spheroids, a more accurate reflection clinical behavior vitro than conventional adherent cultures. By performing RNA-seq analysis, we found that focal adhesion pathway was essential spheroids. The phosphorylation kinase (FAK) increased spheroids compared cells, and inhibition...
Abstract Background Human papillomavirus (HPV) infection is a primary cause of cervical cancer. Although epidemiologic study revealed that carcinogenic risk differs according to HPV genotypes, the expression patterns HPV-derived transcripts and their dependence on genotypes have not yet been fully elucidated. Methods In this study, 382 patients with abnormal cytology were enrolled assess associations between intraepithelial neoplasia (CIN) grades and/or genotypes. Specifically, four...
Although many patients with endometrial cancer (EC) or atypical hyperplasia (AEH) achieve complete remission (CR) after high-dose medroxyprogesterone acetate (MPA) treatment, no consensus has been reached on management CR. Currently, receive estrogen-progestin maintenance therapy, but recommendations exist regarding the duration of therapy whether hysterectomy should be considered. This study aimed to provide insights into EC/AEH achieving CR.We retrospectively investigated prognosis 50 EC...
Although lymphovascular space invasion is a prognostic factor for the recurrence of resectable endometrial cancer, differential impacts lymphatic vessel (LVI) and blood (BVI) on cancer are poorly described. We investigated significance LVI BVI their association with patterns recurrence.We retrospectively reviewed 376 patients stage I to III who underwent surgery curative intent at our institution between 2007 2015. The associations presence or recurrence-free survival were...
Colonic metastasis from ovarian cancer is extremely rare, with only seven reported cases. A 77-year-old woman who had previously undergone surgery for was admitted to a local hospital anal bleeding. Histopathological analysis confirmed the presence of adenocarcinoma. Colonoscopy revealed descending colon tumor. The patient diagnosed Union International Cancer Control T3N0M0 or cancer. Laparoscopic left colectomy performed; intraoperative frozen section diagnosis cancer, and absence invasion...