A5101542974- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Virology and Viral Diseases
- Genetic factors in colorectal cancer
- Nutrition and Health in Aging
- Cancer Immunotherapy and Biomarkers
- Anorectal Disease Treatments and Outcomes
- Metastasis and carcinoma case studies
- Lung Cancer Treatments and Mutations
- Cardiac, Anesthesia and Surgical Outcomes
- Esophageal Cancer Research and Treatment
- Frailty in Older Adults
- Neuroendocrine Tumor Research Advances
- Hernia repair and management
- Gastrointestinal Tumor Research and Treatment
- Surgical Simulation and Training
- Ovarian cancer diagnosis and treatment
- Cancer, Lipids, and Metabolism
- Anatomy and Medical Technology
- Multiple and Secondary Primary Cancers
- HIV/AIDS drug development and treatment
- Diverticular Disease and Complications
The University of Tokyo
1997-2025
Jichi Medical University
2018-2023
Jichi Medical University Saitama Medical Center
2023
University of Tokyo Hospital
2023
National Center for Global Health and Medicine
2020-2021
Center for Global Health
2020
Kumamoto University
2008-2019
Jichi Medical University Hospital
2018
Saint John's Health Center
2017
Molecular Oncology (United States)
2017
// Yuzo Nagai 1, 2 , Eiji Sunami 1 Yoko Yamamoto Keisuke Hata Satoshi Okada Koji Murono Yasuda Kensuke Otani Takeshi Nishikawa Toshiaki Tanaka Tomomichi Kiyomatsu Kazushige Kawai Hiroaki Nozawa Soichiro Ishihara Dave S.B. Hoon Watanabe Department of Surgical Oncology, Faculty Medicine, The University Tokyo, Bunkyo-ku, Japan Translational Molecular Div. John Wayne Cancer Institute, Saint John's Hospital and Health Center, Santa Monica, CA, USA Correspondence to: Watanabe, email:...
SUMMARY The pathogenic strain Italien and the apathogenic Ulster of Newcastle disease virus have been compared with respect to organ tropism spread infection in 11-day-old chick embryos. After endodermal layer chorioallantoic membrane by intra-allantoic inoculation Italien, high titres are found all extra-embryonic membranes fluids embryo itself. Infection results early death embryo. In contrast, after same route inoculation, only allantoic sac embryos not killed. Inoculation on ectodermal...
A genetic engineering approach was made to generate a recombinant non-segmented negative- strand RNA virus, Sendai virus (SeV) of the family Paramyxoviridae, that expresses firefly luciferase. The DNA construct containing entire open reading frame (ORF) luciferase gene followed by SeV transcription stop and restart signals connected with conserved intergenic three nucleotides inserted immediately before ORF viral 3′-proximal nucleocapsid (N) protein in full-length cDNA copy. After...
The Sendai virus V protein is a nonstructural trans-frame whose cysteine-rich C-terminal half fused to the acidic N-terminal of P via mRNA editing. We recently created mutant by disrupting editing motif, which devoid and hence unable produce protein, demonstrated that this V(-) replicated normally or even faster with augmented gene expression cytopathogenicity in cells vitro, but was strongly attenuated pathogenicity for mice (A. Kato, K. Kiyotani, Y. Sakai, T. Yoshida, Nagai, EMBO J....
Human immunodeficiency virus type 1 circulates in vivo as a mixture of heterologous populations (quasispecies). We previously analyzed the quasispecies third hypervariable region (V3) viral envelope glycoprotein gp120 an infected individual and found that species with basic amino acid substitution (lysine for aspartic acid) at particular position evolved became distinct population within short period, followed by progression to typical stage (S. Oka et al., AIDS Res. Hum. Retroviruses...
// Kazuko Sakai 1 , Shinsuke Kazama 2 Yuzo Nagai Koji Murono Toshiaki Tanaka Soichiro Ishihara Eiji Sunami Shuta Tomida Kazuto Nishio Watanabe Department of Genome Biology, Kinki University Faculty Medicine, Osaka-Sayama, Osaka, 589-8511, Japan Surgical Oncology, The Tokyo, Bunkyo-ku, 113-8655, Correspondence to: Nishio, e-mail: knishio@med.kindai.ac.jp Watanabe, watanabe-1su@h.u-tokyo.ac.jp Keywords: Chemoradiation, Rectal cancer, TP53, deep sequencing, RNA sequencing Received: July 06,...
Laminin-332 is major component of epithelial basement membrane, and has an important role in cell migration tumour invasion. Recently, the phosphatidylinositol 3-kinase (PI3K) activation induced by laminin-332 during carcinogenesis or invasion been highlighted skin squamous carcinoma. The expression 126 resected oesophageal carcinoma (ESCC) specimens was immunohistochemically examined to determine its associations with clinicopathological characteristics, effect on invasiveness PI3K assessed...
Neoadjuvant chemotherapy - often using docetaxel in various combinatorial regimens is a standard treatment choice for advanced oesophageal squamous cell carcinoma (ESCC) Japan. However, no useful markers exist that predict docetaxel's effects on ESCC. Ribophorin II (RPN2) silencing, which reduces glycosylation of P-glycoproteins and decreases membrane localisation, promotes docetaxel-dependent apoptosis. We investigated whether RPN2 expression ESCC biopsy specimens could be predictive...
Indoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme that converts tryptophan to kynurenine. IDO1 expression found not only in tumor cells but also immune and associated with proliferation responses. inhibitors radiation may cooperatively suppress through the alterations Wnt/β-catenin pathway, cell cycle, response. We investigated antitumor effects of combination therapy inhibitor, 1-methyl (1-MT), on colorectal cancer.In vitro experiments were conducted using human murine colon cancer lines...
Background/Aim: The usefulness of robotic surgery compared to laparoscopic for rectal cancer has been reported; however, few reports exist on abdominoperineal resection (APR). aim this study was compare the outcomes and determine their in patients with locally advanced who had undergone preoperative chemoradiotherapy (CRT). Patients Methods: This retrospective included 43 underwent CRT (22 patients) or APR (21 between December 2012 September 2022. We examined short- long-term groups....
Computed tomographic colonography (CTC) is reported to be feasible for screening of colorectal polyps; however, its efficacy in preoperative workup remains unknown. This study was done define our CTC methodology and assess CTC's potential examination patients with colon cancer.A total 86 cancer underwent prior laparoscopic colectomy department from February 2014 November 2015. The location primary determined by compared that confirmed during the surgery. performed just after colonoscopy; a...
Immune checkpoint inhibitors, such as antibody against programmed cell death protein (PD-1), have demonstrated antitumour effects in patients with malignancies, including oesophageal cancer. A lymphocytic reaction observed by pathological examination is a manifestation of the host immune response to tumour cells. It was hypothesized that stronger tumours might be associated favourable prognosis cancer.Using database resected cancers, four morphological components reactions (peritumoral,...
The incidence of colorectal cancer (CRC) in young people is increasing, indicating an urgent need for understanding young-onset CRC. This study serves to clarify the characteristics and prognosis CRC patients.Using a detailed database, various clinicopathological findings including symptoms, family history 70 patients under 50 years who underwent surgical resection between 2005 2011 were compared 786 old over years. For comparison prognosis, matched 1:4 case-control adjusting gender, tumor...
Abstract Background Minimally invasive surgery (MIS), such as laparoscopic and robotic for rectal cancer, is performed worldwide. However, limited information available on the advantages of MIS over open multivisceral resection cases clinically invading adjacent organs. Patients methods This was a retrospective propensity score-matching study consecutive clinical T4b cancer patients who underwent curative intent between 2006 2021 at University Tokyo Hospital. Results Sixty-nine were...
This study aimed to clarify the relationship between changes in elasticity and anorectal function before after chemoradiotherapy.
Abstract Aim Sarcopenia is associated with poor postoperative outcomes in various cancers; however, limited evidence available for rectal cancer. Therefore, the present study examined effects of skeletal muscle mass on short‐ and long‐term Materials Methods A total 787 Stage I–IV cancer patients who underwent curative resection between 2003 2021 at The University Tokyo Hospital were included. We conducted a propensity score‐matched analysis to mitigate confounding bias. third lumber psoas...