A5100694714- Streptococcal Infections and Treatments
- Neonatal and Maternal Infections
- Regulation of Appetite and Obesity
- Gastrointestinal motility and disorders
- Ovarian cancer diagnosis and treatment
- Nutritional Studies and Diet
- Chronic Lymphocytic Leukemia Research
- Acute Ischemic Stroke Management
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Blood properties and coagulation
- Drug Transport and Resistance Mechanisms
- Tea Polyphenols and Effects
- Uterine Myomas and Treatments
- Rheumatoid Arthritis Research and Therapies
- Pancreatic function and diabetes
- Apelin-related biomedical research
- Venous Thromboembolism Diagnosis and Management
- Helicobacter pylori-related gastroenterology studies
- Circadian rhythm and melatonin
- Platelet Disorders and Treatments
- Neonatal Health and Biochemistry
- Otitis Media and Relapsing Polychondritis
- Nutrition, Health and Food Behavior
- Dietetics, Nutrition, and Education
Kobe Pharmaceutical University
2025
Toranomon Hospital
2024
Tokyo Metropolitan Police Hospital
2023-2024
Izumi City General Hospital
2023
St. Luke's International University
2023
Keio University Hospital
2021
Tokyo Women's Medical University Adachi Medical Center
2013-2017
Kiryu University
2010-2014
National Institute of Infectious Diseases
2014
Tottori University
2014
To clarify the incidence and prognosis of early-onset (EOD) late-onset (LOD) GBS disease in Japan. evaluate influence national guidelines issued 2008 on epidemiology disease.Retrospective nationwide questionnaire surveillance culture-confirmed infections between 2004 2010.Eighty-eight EOD 162 LOD cases were reported from 152 participating hospitals. The case fatality was 13.6% 8.0%. Premature birth <37 weeks (p<0.001) low weight <2500 g significantly associated with mortality. A high rate...
Summary. To clarify the mechanisms underlying thrombocytosis secondary to infections, we longitudinally studied serum levels of thrombopoietin (TPO) and interleukin (IL)‐6 in 15 infants young children with prominent (platelets > 700 × 10 9 /l) following acute infections 116 age‐matched controls using an enzyme‐linked immunosorbent assay. The subjects included nine patients bacterial three viral non‐determined pathogens. TPO values were 2·24 ± 0·87 fmol/ml (mean SD) a 95% reference...
We studied thrombopoietin (TPO, Mpl ligand) values using a sensitive ELISA in 254 serum samples obtained from disease‐free children and adult volunteers. TPO was detected all samples, its ranged widely 0.25 to 9.18 fmol/ml. When analysed by dividing the subjects into 11 age groups, mean levels birth 1 month of were increased (3.73–5.92 fmol/ml). The highest found 2 d after birth; then gradually decreased (0.83 relationship between platelet counts not significant ( r = 0.27) or alone 0.12)....
BACKGROUND: Although laboratory experiments suggest protective effects of green tea against colorectal cancer, few prospective cohort studies have been conducted.METHODS: We conducted a pooled analysis two among residents in Miyagi Prefecture rural northern Japan. The first study started 1984 and included 26,311 subjects. second 1990 39,604 subjects responded to selfadministered questionnaire including an item on consumption. With 7 9 years follow-up, 305 colon 211 rectal cancers were...
Neutrophils accumulate initially in the cerebrospinal fluid (CSF) of aseptic meningitis, perhaps because increased levels granulocyte colony-stimulating factor (G-CSF), macrophage inflammatory protein-1alpha (MIP-1alpha), and IL-8 subarachnoid space. We studied these cytokines children with meningitis using ELISA. When meningeal symptoms existed, (1399 +/- 1600 ng/l, n = 32) CSF were significantly higher than those either after disappeared (61 56 18) or controls (44 63 27) (P < 0.0001). High...
Abstract Background The taxane cabazitaxel (CBZ) is a promising treatment for docetaxel-resistant castration-resistant prostate cancer (CRPC). However, the survival benefit with CBZ patients CRPC limited. This study used screening tests candidate drugs targeting CBZ-resistant-related gene expression and identified pimozide as potential overcoming resistance in CRPC. Methods We established CBZ-resistant cell lines, DU145CR PC3CR by incubating DU145 cells PC3 gradually increasing...
The survey was designed to determine the trend of group B streptococcal (GBS) infection during last 15 years, as well update reality this disease.Questionnaires were administered every 5 years towards neonatal intensive care unit-equipped hospitals. first made from 1983 1987, second one 1988 1992 and third 1993 1997. 15-year questionnaire included a total 831 patients. changes in number patients, ages at onset, diagnosis, serotypes causative agents, presence or absence complicated delivery...
In obese humans and animals, adiponectin production release in adipose tissue are downregulated by feedback inhibition, resulting decreased serum adiponectin. We investigated ventromedial hypothalamic (VMH)-lesioned animals. VMH-lesioned mice showed significant increases food intake body weight gain, with hyperinsulinemia hyperleptinemia at 1 4 weeks after VMH-lesioning. Serum was elevated weeks, despite adipocyte hypertrophy subcutaneous visceral tissues increased fat. Adiponectin mRNA were...
We present a case of recurrent ovarian cancer at the age 75, gravida 1 para 0, with 18 years disease-free survival. Chemotherapy brought 10-month partial response status; to further improve overall survival, patient was evaluated using AGO score (DESKTOP III trial, 2020), which originally intended for cases immediately after diagnosis recurrence; has indicated significant outcome; went through hepatosplenic metastatic site resection; and complete resection achieved. Subsequently, PARP...
Evidence is limited regarding the association between combinations of multiple health practices and mortality.In 1990, 28,333 men women in Miyagi Prefecture rural northern Japan (40-64 year age) completed a self-administered questionnaire. A lifestyle score was calculated by adding number high-risk (smoking, consuming > or = 22.8 g alcohol/d, walking < 1 hr/d, body mass index 18.5 30.0). Cox regression used to estimate relative risk (RR) mortality according score, with adjustment for age,...
We previously reported that vagal hyperactivity produced by ventromedial hypothalamic (VMH) lesions stimulated cell proliferation of rat pancreatic islet B and acinar cells primarily through a cholinergic receptor mechanism.This study examined how gene families involved in are regulated after VMH formation. Total RNA was extracted, differences the expression profiles between rats at day 3 lesioning sham-VMH-lesioned were investigated using DNA microarray real-time polymerase chain...
We have found that ventromedial hypothalamic (VMH) lesions produced by electrocoagulation induce cell proliferation in visceral organs through vagal hyperactivity, and also stimulate regeneration of partially resected liver rats. To facilitate identification proliferative and/or regenerative factors at the gene level, we developed electrical production VMH mice, for which more genetic information is available compared to rats, examined pathophysiological profiles these mice. Using ddy with...
Gynecologic robotic surgery in Japan has been listed within the insurance coverage since 2018. also developed Hinotori™ Robotic Assisted Surgery System and with rise of medical robots, percentage surgeries is expected to increase further future. This paper summarizes current Japanese status, literature searched from Pubmed on each procedure, existing products, perspectives. The amount blood loss, hospital stay, complications benign diseases procedures such as myomectomy, simple hysterectomy,...