A5080278594- Urinary Tract Infections Management
- Nephrotoxicity and Medicinal Plants
- Neuroscience and Neuropharmacology Research
- Lysosomal Storage Disorders Research
- Antibiotics Pharmacokinetics and Efficacy
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Cellular transport and secretion
- Pregnancy and Medication Impact
- Fibroblast Growth Factor Research
- Lipid Membrane Structure and Behavior
- Escherichia coli research studies
- Rocket and propulsion systems research
- Spacecraft Design and Technology
- Neuropeptides and Animal Physiology
- Muscle Physiology and Disorders
- Axon Guidance and Neuronal Signaling
- Spinal Dysraphism and Malformations
- Alzheimer's disease research and treatments
- Photoreceptor and optogenetics research
- Pain Mechanisms and Treatments
- Glycosylation and Glycoproteins Research
- Nitric Oxide and Endothelin Effects
- Pharmacological Effects and Toxicity Studies
Ehime University
2015-2025
Hokkaido Information University
2025
Kyocera (Japan)
2020-2021
Japan Broadcasting Corporation (Japan)
2021
Yole Développement (France)
2021
AlphaMicron (United States)
2020
IHI Corporation (Czechia)
2013
The University of Tokyo
1985-2012
Gunze (Japan)
2008
Koto Hospital
1994-2006
Erythropoietin (EPO) produced by the kidney and liver (in fetuses) stimulates erythropoiesis. In central nervous system, neurons express EPO receptor (EPOR) astrocytes produce EPO. has been shown to protect primary cultured from N -methyl- d -aspartate (NMDA) receptor-mediated glutamate toxicity. Here we report in vivo evidence that protects against ischemia-induced cell death. Infusion of into lateral ventricles gerbils prevented learning disability rescued hippocampal CA1 lethal ischemic...
Muscle-specific kinase (MuSK) is critical for the synaptic clustering of nicotinic acetylcholine receptors (AChRs) and plays multiple roles in organization maintenance neuromuscular junctions (NMJs). MuSK activated by agrin, which released from motoneurons, induces AChR at postsynaptic membrane. Although autoantibodies against ectodomain have been found a proportion patients with generalized myasthenia gravis (MG), it unclear whether are causative agent MG. In present study, rabbits...
While menin plays an important role in preventing T-cell dysfunction, such as senescence and exhaustion, the regulatory mechanisms remain unclear. We found that prevents induction of dysfunction activated CD8 T cells by restricting cellular metabolism. mTOR complex 1 (mTORC1) signaling, glycolysis, glutaminolysis are augmented deficiency. Rapamycin treatment menin-deficient cells. Limited glutamine availability also induced deficiency, its inhibitory effect is antagonized α-ketoglutarate...
SARS-CoV-2 infection during conception or early pregnancy may have increased risk to develop neurodevelopmental defects in the developing fetus.
Abstract: Prosaposin, a multifunctional protein, is the precursor of saposins, which activate sphingolipid hydrolases. In addition to acting as for prosaposin has been shown rescue hippocampal CA1 neurons from lethal ischemic damage in vivo and promote neurite extension neuroblastoma cells vitro. Here we show that prosaposin, when added collagen‐filled nerve guide after sciatic transection guinea pigs, increased dramatically number regenerating fibers within guide. To identify target during...
Abstract: Prosaposin, a 517‐amino‐acid glycoprotein, not only acts as the precursor of saposin A, B, C, and D but also possesses neurotrophic activity to rescue hippocampal CA1 neurons from ischemic damage in vivo promote neurite extension neuroblastoma cells vitro. Recently, trophic prosaposin on human has been shown reside NH 2 ‐terminal hydrophilic sequence (LIDNNRTEEILY) C. Here we show that prosaposin, peptide comprising 18‐amino‐acid (18‐mer peptide; LSELIINNATEELLIKGL) located rat...
Epidermal growth factor (EGF) has been considered to be a candidate for neurotrophic factors on the basis of results several in vitro studies. However, vivo effect EGF ischemic neurons as well its mechanism action have not fully understood. In present study using gerbil ischemia model, we examined effects ischemia-induced learning disability and hippocampal CA1 neuron damage. Cerebroventricular infusion (24 or 120 ng/d) 7 days gerbils starting 2 hours before immediately after transient...
Abstract There is wide variation in brain shape among birds. Differences dimensions reflect species‐specific sensory capacities and behavioral repertoires that are shaped by environmental biological factors during evolution. Most previous studies aimed at defining impacting have used volumetric or linear measurements. However, few explored the quantitative indices of three‐dimensional (3 D ) geometry absolutely imperative to understanding avian evolutionary history. This study aimed: (i)...
It is known that proliferation and apoptosis are closely related phenomena in liver cancer cells. In this study, using surgical specimens from 42 patients with hepatocellular carcinoma (HCC), we investigated the expression localization of Bcl-xL, an antiapoptosis-related protein Bcl-2 family. Using Western blotting, Bcl-xL was detected both cancerous non-cancerous all HCC patients, elevated levels were found two thirds patients. normal human specimens, mainly cytoplasm hepatocytes, although...
Abstract: In vivo brain microdialysis experiments were performed in the gerbil to evaluate origin of accumulation extracellular glutamate under transient ischemia. Microdialysis probes positioned CA1 field hippocampus which proliferation astrocytes, death pyramidal neurons, and damage presynaptic terminals had been induced by 5‐min ischemia 10–14 days before experiment; white matter cerebral cortex, contained few terminals, many astrocytes; or histologically normal hippocampus, then 5‐...
During the past 10 years, clinicians have used two-piece implants as a one-piece system for immediate loading to accomplish early recovery function and esthetics. The statistical analysis by Institute of Clinical Materials demonstrates high survival rates 92.3 ± 8.3%. Animal experiments beagle dogs been carried out analyze successful conditions according dependency bone formation–resorption upon biomechanical stress–strain bone. Histometric investigations clarified that micromotion less than...