A5047915959- Hepatitis B Virus Studies
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Liver Disease and Transplantation
- Immunotherapy and Immune Responses
- COVID-19 epidemiological studies
- Viral gastroenteritis research and epidemiology
- MicroRNA in disease regulation
- Machine Learning in Bioinformatics
- Parasites and Host Interactions
- Cancer-related gene regulation
- Mosquito-borne diseases and control
- Fixed Point Theorems Analysis
- Parasitic Diseases Research and Treatment
- Liver Diseases and Immunity
- Asian Geopolitics and Ethnography
- COVID-19 Clinical Research Studies
- Liver physiology and pathology
- Ferroptosis and cancer prognosis
- Malaria Research and Control
Miyakawa Memorial Research Foundation
2019-2024
Clinical Research Organization
2022-2024
Ehime University
2009-2024
Oita University
2023-2024
Uehara Memorial Foundation
2019-2024
Bangabandhu Sheikh Mujib Medical University
2014-2019
Tokyo Shinagawa Hospital
1970-2017
Toshiba (Japan)
2010-2013
Weatherford College
2009-2013
Nipah virus (NiV), a bat-borne zoonotic pathogen, poses persistent threats to global public health due severe clinical manifestation and high case fatality rate (CFR). A critical examination of NiV outbreaks is essential for refining strategies mitigating the impact future infections. In this study, we provide concise update on that occurred during past 25 years.
SARS-CoV-2 infection during conception or early pregnancy may have increased risk to develop neurodevelopmental defects in the developing fetus.
The outbreak of coronavirus disease 2019 (COVID-19) devastated the overall health management strategy most countries. In this scenario, present study provided insights into possible impact COVID-19 pandemic on dengue infection. This ecological retrieved data from WHO/Government reporting system 22 major epidemic Incidence infections during pre-COVID-19 time (2015~2019) and period (2020~2021) was compared. A correlation between cases predicted incidence in 2022 calculated using linear...
Aim: In developed countries including Japan, the transmission route of indigenous hepatitis E virus (HEV) infection is obscure. Accordingly, public health implications HEV have not been well addressed. The aim this study was to clarify a small outbreak acute and assess zoonotic transmission. Methods: Three patients with non‐A, B C hepatitis, two whom presented in critical condition, were assessed for using polymerase chain reaction their infection; genome sequences infecting also analyzed. A...
Dengue, a life-threatening disease caused by the mosquito-borne dengue virus, has become severe problem in recent years Bangladesh, South Asian country. In this study, we have critically analyzed factors contributing to escalation of burden Bangladesh and discussed strategies for effective control. This retrospective observational study data collected from five most dengue-affected countries (Bangladesh, Brazil, Mexico, Peru, Philippines) 2019 2023. An increased number dengue-related deaths...
To eliminate hepatitis B virus (HBV) infection, it is essential to scale up testing and treatment. However, conventional tools assess treatment eligibility, particularly nucleic acid (NAT) quantify HBV DNA, are hardly available affordable in resource-limited countries. We therefore assessed the performance of a novel immunoassay, core-related antigen (HBcrAg), as an inexpensive (US$ <15/assay) alternative NAT diagnose clinically important DNA thresholds (≥2000, ≥20 000, ≥200 000 IU/mL)...
In this paper, we introduced the new concept of a graphical presentation approach in C ∗ ‐algebra‐valued b ‐metric space ( AVbM‐space). We studied some modified contraction conditions for single‐valued mappings AVbM‐spaces and proved uniqueness fixed point (FP) results said with nontrivial illustrative examples. Moreover, constructed tables graphs support our theoretical AVbM‐spaces. addition, established an application to operator fuzzy differential equations existence unique solution...
Myeloid-derived suppressor cells (MDSCs) are potent suppressors of T cell immunity in tumors and inflammatory diseases. They identified by surface expression CD11b+Gr1+ mice, accumulate the livers obese mice. However, many myeloid share these markers. Accordingly, aim this study was to identify authentic phenotype MDSCs investigate their functions non-alcoholic fatty liver disease (NAFLD). C57BL/6J mice were divided into 2 diet groups: a normal control group high-fat induce NAFLD. We...
Introduction There is a pressing need to develop novel drugs for treating patients with chronic hepatitis B (CHB), as commercially available antiviral are endowed safety and efficacy concerns. Methods A phase III clinical trial was conducted therapeutic vaccine containing two antigens of the virus (HBV; named NASVAC) in 78 CHB expressing both HBV DNA elevated levels alanine aminotransferase (ALT) blood. Five years after end treatment (EOT), 60 NASVAC-recipient were enrolled this long-term...
Commercially available prophylactic vaccines containing hepatitis B surface antigen (HBsAg), which are used to prevent HBV infections, not as effective a therapeutic immune modulator for treating patients with chronic (CHB). In this study, the immunogenicity of dendritic cells (DC) loaded both HBsAg and core (HBcAg) was tested in transgenic mice (TM; 1.2HB-BS10) vivo CHB vitro.Spleen DC from TM were cultured vaccine HBcAg produce HBsAg/HBcAg-pulsed DC. immunized twice at an interval 4 weeks...
A phase III clinical trial in treatment-naïve patients with chronic hepatitis B (CHB) revealed the safety and considerable therapeutic efficacy of a vaccine containing both surface antigen (HBsAg) core (HBcAg) (NASVAC) at end treatment (EOT) 24 weeks after EOT. Two years EOT, we checked HBV DNA, alanine aminotransferase (ALT), e (HBeAg). The data reveal that 33 66 NASVAC-recipient CHB became negative for DNA blood two ALT levels were within upper limit normal (ULN) 37 patients, although all...
Abstract Acute hepatitis due to E virus (HEV) is endemic in Bangladesh, but its epidemiological characteristics and virological features remain obscure. An outbreak of acute icteric occurred Rajshahi, Bangladesh during 2010 when 200 patients with visible jaundice visited physicians within a period 1 month (January–February). Clinical data were collected from these using questionnaires. Nucleic acids isolated 15 who selected at random ascertain their HEV genotypes. Near‐complete nucleotide...
Infection with the hepatitis E virus (HEV) can cause acute in endemic areas immune-competent hosts, as well chronic infection immune-compromised subjects non-endemic areas. Most studies assessing HEV HIV-infected populations have been performed developed countries that are usually affected by genotype 3. The objective of this study is to measure prevalence and risk acquiring among individuals Nepal.We prospectively evaluated 459 Human Immunodeficiency Virus (HIV)-positive from Nepal, an...
Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination early diagnosis of hepatoma, complications their preventions treatments, etc.
Hepatitis B vaccine induces the production of antibodies against hepatitis surface antigen (anti-HBs) and prevents virus (HBV) infection. However, 5-10% individuals cannot develop anti-HBs even after multiple vaccinations (HB non-responders). We developed an intranasal containing both HBs (HBsAg) HB core (HBcAg) mixed it with a viscosity enhancer, carboxyl vinyl polymer (CVP-NASVAC). Here, we investigated prophylactic capacity CVP-NASVAC in non-responders. Thirty-four non-responders were...
The objective of the present study was to assess safety and efficacy a therapeutic vaccine containing both HBsAg HBcAg (NASVAC) in patients with chronic hepatitis B (CHB) three years after end treatment (EOT) as follow-up phase III clinical trial. NASVAC administered ten times by nasal route five subcutaneous injection. A total 59 CHB were enrolled. Adverse events not seen any patients. Out patients, 54 exhibited reduction HBV DNA, compared their basal levels. Although all had alanine...
Patients with inactive chronic hepatitis B virus (HBV) infection are assumed to be free from liver disease. Accordingly, antiviral drug treatment is not recommended for these patients. However, the extent of damage in patients has been evaluated fully. The aim this study was evaluate HBV. Liver biopsy conducted 141 HBV carriers [HBeAg-negative, low levels DNA (<or=10,000 copies/ml) and normal serum alanine aminotransferase (ALT)]. hepatic inflammation fibrosis by examining specimens....