A5070736167- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Diabetes Treatment and Management
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Diabetes Management and Research
- Pancreatic function and diabetes
- Diet and metabolism studies
- Cardiac Health and Mental Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular and exercise physiology
- Diet, Metabolism, and Disease
- Cardiovascular Health and Risk Factors
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Effects of Exercise
- Dietary Effects on Health
- Bariatric Surgery and Outcomes
- Heart rate and cardiovascular health
- Heart Failure Treatment and Management
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
University of Pisa
2021-2024
OBJECTIVE To evaluate the prognostic value of glomerular hyperfiltration on long-term kidney-related outcomes and mortality in patients with diabetes. RESEARCH DESIGN AND METHODS We retrospectively analyzed 21-year longitudinal data from 314 long-standing type 1 or 2 Glomerular was identified based age- sex-specific distribution measured filtration rate (mGFR) by 99mTc-DTPA dynamic renal scintigraphy. The primary outcome a composite doubling serum creatinine, end-stage kidney disease (ESKD),...
Abstract Background The prognostic value of common and frequently associated diabetic microvascular complications (MVC), namely chronic kidney disease (CKD), cardiac autonomic neuropathy (CAN), peripheral (DPN), retinopathy (DR), is well established. However, the impact their different combinations on long-term mortality has not been adequately assessed. Methods We retrospectively analyzed 21-year longitudinal data from 303 patients with long-standing type 1 (T1D) or 2 diabetes (T2D), who...
Abstract Aims To establish the long‐term prognostic value of abnormal circadian blood pressure (BP) patterns in diabetes. Materials and Methods We retrospectively examined a cohort 349 outpatients with diabetes who were screened for microvascular complications followed up 21 years. Dipping, nondipping reverse‐dipping status defined based on 24‐hour ambulatory BP monitoring (ABPM) as ≥10% reduction, <10% any increase average nighttime versus daytime systolic (SBP), respectively. Results...
Abstract Aims/hypothesis Early time-restricted carbohydrate consumption (eTRC) is a novel dietary strategy that involves restricting carbohydrate-rich food intake to the morning and early afternoon align with circadian variations in glucose tolerance. We examined efficacy, feasibility safety of eTRC individuals type 2 diabetes under free-living conditions. Methods In this randomised, parallel-arm, open label, controlled trial, participants overweight/obesity (age 67.2±7.9 years, 47.8% women,...
Abstract Context Hypertriglyceridemia is a risk factor for developing type 2 diabetes (T2D) and might contribute to its pathogenesis either directly or through elevation of nonesterified fatty acids (NEFAs). Objective This study aimed at comparing the glucometabolic effects acute hypertriglyceridemia alone combined with NEFA in subjects without diabetes. Methods Twenty-two healthy lean volunteers underwent 5-hour intravenous infusions saline Intralipid, (n = 12) heparin (I + H; n 10)...
Effort intolerance is frequent in patients with overweight/obesity and/or type 2 diabetes (T2D) free from cardiac and respiratory disease. We sought to quantify the independent effects of T2D body mass index (BMI) on cardiopulmonary capacity gain insights possible pathophysiology by case-control regression analyses.Patients at high/moderate cardiovascular risk, or without T2D, underwent spirometry combined echocardiography-cardiopulmonary exercise test as part their clinical workup. Subjects...
Background The effects of sacubitril/valsartan (sac/val) on metabolic parameters and insulin resistance (IR) in non-obese/prediabetic patients have not been previously described. Aim To evaluate the sac/val glycemic parameters, Homeostatic Model Assessment IR (HOMA-IR), echocardiographic prediabetic with heart failure reduced ejection fraction (HFrEF). Methods Fifty-nine HFrEF (EF &lt; 35%) but without obesity and/or type 2 diabetes mellitus enrolled. All at baseline week 24 underwent...
Abstract Background Circadian heart rate (HR) fluctuations are associated with cardiovascular health. We examined their relationship microvascular disease and long-term survival in patients diabetes. Methods In this secondary analysis from the CHAMP1ON cohort of 497 adults metabolic disease, 349 participants who had type 1 or 2 diabetes, baseline 24h ambulatory blood pressure HR monitoring (ABPM), data over a 21-year observational follow-up were included. Clinical features, complications,...
<p> </p> <p><em><strong>Objective.</strong></em> To evaluate the prognostic value of glomerular hyperfiltration on long-term kidney-related outcomes and mortality in subjects with diabetes.</p> <p><em><strong>Methods</strong></em><strong>. </strong>We retrospectively analyzed 21-year longitudinal data from 314 patients long-standing type 2 or 1 diabetes. Glomerular was identified based age- sex-specific...
<p> </p> <p><em><strong>Objective.</strong></em> To evaluate the prognostic value of glomerular hyperfiltration on long-term kidney-related outcomes and mortality in subjects with diabetes.</p> <p><em><strong>Methods</strong></em><strong>. </strong>We retrospectively analyzed 21-year longitudinal data from 314 patients long-standing type 2 or 1 diabetes. Glomerular was identified based age- sex-specific...
Background: Abnormal circadian blood pressure (BP) patterns and reduced heart rate variability (HRV) are established risk factors for cardiovascular events in diabetic patients. However, studies assessing all-cause mortality associated with altered BP HRV diabetes limited by follow-up periods of less than 10 years. Methods: We examined a cohort 349 patients type 2 ( n =284) or 1 =65) recruited Pisa (Italy) from 1999 followed-up 21 years, all available 24-hour ambulatory monitoring. Dipping,...