A5072473792- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Multiple and Secondary Primary Cancers
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Economic and Financial Impacts of Cancer
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Infection Control in Healthcare
- Chronic Kidney Disease and Diabetes
- Infection Control and Ventilation
- Bacterial biofilms and quorum sensing
- Genetic Associations and Epidemiology
- Hormonal Regulation and Hypertension
- Cardiovascular Disease and Adiposity
- Renin-Angiotensin System Studies
- Diet, Metabolism, and Disease
- Safe Handling of Antineoplastic Drugs
- Machine Learning in Healthcare
- Adipokines, Inflammation, and Metabolic Diseases
- Bone Tissue Engineering Materials
- Nanoparticles: synthesis and applications
University of Pisa
2020-2024
Scuola Superiore Sant'Anna
2022-2024
Abstract The prevalence of longstanding chronic diseases has increased worldwide, along with the average age population. As a result, an increasing number people is affected by two or more conditions simultaneously, and healthcare systems are facing challenge treating multimorbid patients effectively. Current therapeutic strategies suited to manage each condition separately, without considering whole clinical patient. This approach may lead suboptimal outcomes system inefficiencies (e.g....
Abstract Background The prognostic value of common and frequently associated diabetic microvascular complications (MVC), namely chronic kidney disease (CKD), cardiac autonomic neuropathy (CAN), peripheral (DPN), retinopathy (DR), is well established. However, the impact their different combinations on long-term mortality has not been adequately assessed. Methods We retrospectively analyzed 21-year longitudinal data from 303 patients with long-standing type 1 (T1D) or 2 diabetes (T2D), who...
Abstract Purpose: AtezoTRIBE phase II randomized study demonstrated that adding atezolizumab to first-line FOLFOXIRI (5-fluorouracil, oxaliplatin, irinotecan) plus bevacizumab prolongs progression-free survival (PFS) of patients with metastatic colorectal cancer (mCRC), a modest benefit among proficient mismatch repair (pMMR). DetermaIO is an immune-related 27-gene expression signature able predict from immune checkpoint inhibition in triple-negative breast cancer. In this analysis...
Abstract Aims To establish the long‐term prognostic value of abnormal circadian blood pressure (BP) patterns in diabetes. Materials and Methods We retrospectively examined a cohort 349 outpatients with diabetes who were screened for microvascular complications followed up 21 years. Dipping, nondipping reverse‐dipping status defined based on 24‐hour ambulatory BP monitoring (ABPM) as ≥10% reduction, <10% any increase average nighttime versus daytime systolic (SBP), respectively. Results...
Preliminary evidence suggests that the glutamate-serine-glycine (GSG) index, which combines three amino acids involved in glutathione synthesis, may be used as a potential biomarker of non-alcoholic fatty liver disease (NAFLD). We investigated whether GSG index is associated with NAFLD youth, independent other risk factors. Intrahepatic fat content (HFF%) and abdominal distribution were measured by magnetic resonance imaging (MRI) multiethnic cohort obese adolescents, including Caucasians,...
The bio-engineering technologies of medical devices through nano-structuring and coating was recently proposed to improve biocompatibility reduce microbial adhesion in the prevention implantable device-related infections. Our aim evaluate ability new nano-structured coated materials prevent biofilm formation, according American Standard Test Method ASTM-E2647-13. composition determined by X-ray Fluorescence Laser Induced Breakdown Spectroscopy. Silver release evaluated Inductively Coupled...
In the past few decades, inadequate reprocessing of bronchoscopes has been associated with several serious outbreaks caused by multidrug-resistant microorganisms. this study we evaluated improvement in quality a Bronchoscopy Unit (BU), after introduction new procedure.
The pathophysiological link between adiposity and blood pressure is not completely understood, evidence suggests an influence of sex genetic determinants. We aimed to identify the relationship pressure, independent a robust set lifestyle metabolic factors, examine modulating role Angiotensin-Converting Enzyme (ACE) insertion/deletion (I/D) polymorphisms. In Relationship Between Insulin Sensitivity Cardiovascular Disease (RISC) study cohort, 1211 normotensive individuals, aged 30 60 years...
<div>Abstract<p>Background: AtezoTRIBE phase II randomized study demonstrated that adding atezolizumab to first-line FOLFOXIRI (5fluoruracil, oxaliplatin, irinotecan) plus bevacizumab prolongs progression-free survival (PFS) of metastatic colorectal cancer (mCRC) patients, with a modest benefit among proficient mismatch repair (pMMR). DetermaIO is an immune-related 27-gene expression signature able predict from immune-checkpoint inhibition in triple-negative breast cancer. In...
<p>Kaplan Meier estimates of progression-free survival in the overall population (optimized cut-point), according to IO status (a) and both treatment arm (b). Legend: HR: hazard ratio, NR: not reached. Control indicates FOLFOXIRI plus bevacizumab. Atezo bevacizumab atezolizumab.</p>
<p>Kaplan Meier estimates of progression-free survival in the pMMR population (optimized cut-point), according to IO status (a) and both treatment arm (b). Legend: HR: hazard ratio, NR: not reached. Control indicates FOLFOXIRI plus bevacizumab. Atezo bevacizumab atezolizumab.</p>
<p>Consort diagram of the study. Control arm indicates FOLFOXIRI plus bevacizumab. Atezo bevacizumab and atezolizumab.</p>
<p>Consort diagram of the study. Control arm indicates FOLFOXIRI plus bevacizumab. Atezo bevacizumab and atezolizumab.</p>
<p>Kaplan Meier estimates of progression-free survival in the pMMR population (optimized cut-point), according to IO status (a) and both treatment arm (b). Legend: HR: hazard ratio, NR: not reached. Control indicates FOLFOXIRI plus bevacizumab. Atezo bevacizumab atezolizumab.</p>
<p>Kaplan Meier estimates of progression-free survival in the overall population (optimized cut-point), according to IO status (a) and both treatment arm (b). Legend: HR: hazard ratio, NR: not reached. Control indicates FOLFOXIRI plus bevacizumab. Atezo bevacizumab atezolizumab.</p>
Abstract Background Circadian heart rate (HR) fluctuations are associated with cardiovascular health. We examined their relationship microvascular disease and long-term survival in patients diabetes. Methods In this secondary analysis from the CHAMP1ON cohort of 497 adults metabolic disease, 349 participants who had type 1 or 2 diabetes, baseline 24h ambulatory blood pressure HR monitoring (ABPM), data over a 21-year observational follow-up were included. Clinical features, complications,...
<div>AbstractPurpose:<p>AtezoTRIBE phase II randomized study demonstrated that adding atezolizumab to first-line FOLFOXIRI (5-fluorouracil, oxaliplatin, irinotecan) plus bevacizumab prolongs progression-free survival (PFS) of patients with metastatic colorectal cancer (mCRC), a modest benefit among proficient mismatch repair (pMMR). DetermaIO is an immune-related 27-gene expression signature able predict from immune checkpoint inhibition in triple-negative breast cancer. In this...
<p>Kaplan Meier estimates of progression-free survival in the pMMR population (optimized cut-point), according to IO status (a) and both treatment arm (b). Legend: HR: hazard ratio, NR: not reached. Control indicates FOLFOXIRI plus bevacizumab. Atezo bevacizumab atezolizumab.</p>
<div>Abstract<p>Background: AtezoTRIBE phase II randomized study demonstrated that adding atezolizumab to first-line FOLFOXIRI (5fluoruracil, oxaliplatin, irinotecan) plus bevacizumab prolongs progression-free survival (PFS) of metastatic colorectal cancer (mCRC) patients, with a modest benefit among proficient mismatch repair (pMMR). DetermaIO is an immune-related 27-gene expression signature able predict from immune-checkpoint inhibition in triple-negative breast cancer. In...