A5037874485- interferon and immune responses
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Influenza Virus Research Studies
- Tuberculosis Research and Epidemiology
- Inflammasome and immune disorders
- Mycobacterium research and diagnosis
- Toxin Mechanisms and Immunotoxins
- Antimicrobial Peptides and Activities
- Immunodeficiency and Autoimmune Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Transgenic Plants and Applications
- Vector-borne infectious diseases
- Monoclonal and Polyclonal Antibodies Research
- Rabies epidemiology and control
The Ohio State University
2021-2024
Harvard University
2019
Ragon Institute of MGH, MIT and Harvard
2019
Significance We report the discovery of fundamental roles for noncanonical inflammasome molecule Caspase-4/11 in promoting pathological inflammatory and prothrombotic pathways severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) infections. Our work demonstrates that Caspase-11 has a broader role immune responses beyond its previously appreciated effects bacterial Further, we show Caspase-11–deficient mice infected with SARS–CoV-2 fare significantly better terms overall illness, lung...
Abstract Interferon‐induced transmembrane protein 3 (IFITM3) is an antiviral that alters cell membranes to block fusion of viruses. Conflicting reports identified opposing effects IFITM3 on SARS‐CoV‐2 infection cells, and its impact viral pathogenesis in vivo remains unclear. Here, we show knockout (KO) mice infected with experience extreme weight loss lethality compared mild wild‐type (WT) mice. KO have higher lung titers increases inflammatory cytokine levels, immune infiltration,...
Cardiac dysfunction is a common complication of severe influenza virus infection, but whether this occurs due to direct infection cardiac tissue or indirectly through systemic lung inflammation remains unclear. To test the etiology aspect disease, we generated novel recombinant heart-attenuated via genome incorporation target sequences for miRNAs expressed in cardiomyocytes. Compared with control virus, mice infected miR-targeted had significantly reduced heart viral titers, confirming...
ABSTRACT Interferon-induced transmembrane protein 3 (IFITM3) is a host antiviral that alters cell membranes to block fusion of viruses. Published reports have identified conflicting pro- and effects IFITM3 on SARS-CoV-2 in cultured cells, its impact viral pathogenesis vivo remains unclear. Here, we show knockout (KO) mice infected with mouse-adapted experienced extreme weight loss lethality, while wild type (WT) lost minimal recovered. KO had higher lung titers increases inflammatory...
Abstract SARS-CoV-2 is a worldwide health concern, and new treatment strategies are needed 1 . Targeting inflammatory innate immunity pathways holds therapeutic promise, but effective molecular targets remain elusive. Here, we show that human caspase-4 (CASP4), its mouse homologue, caspase-11 (CASP11), upregulated in infections, CASP4 expression correlates with severity of infection humans. SARS-CoV-2-infected Casp11 -/- mice were protected from severe weight loss lung pathology, including...
Ehrlichiosis is a potentially life-threatening disease caused by infection with the obligatory intracellular bacteria Ehrlichia species. japonica of mice provides an animal model ehrlichiosis as it recapitulates full-spectrum and lethal in humans. The E. transposon mutant EHF0962 , which encodes previously uncharacterized hypothetical protein, attenuated both virulence mice. was hence named here resistance-inducing protein (RipE). Using this Δ ripE mutant, we studied how RipE contributes to...
Abstract SARS-CoV-2 remains a significant global health burden. A better understanding of the requirements for protective host immunity against will contribute to development novel therapeutic strategies prevent disease. Type III interferon (IFN-lambda) limits infection in vitro and murine models infection. In clinical trials, IFN-lambda treatment accelerates viral clearance reduces risk hospitalization. However, roles regulating pathogenesis are not well understood. Infection C57BL/6 (WT)...
Abstract Cardiac dysfunction is a common extrapulmonary complication of severe influenza virus infection. Prevailing models propose that influenza-associated heart indirectly triggered by cytokine mediated cardiotoxicity downstream the inflamed lung, rather than direct infection cardiac tissue. To test etiology resulting from infection, we generated novel recombinant H1N1 A was attenuated in cardiomyocytes incorporation target sequences for miRNAs expressed specifically cell type (miR133b...