A5071569500- Influenza Virus Research Studies
- interferon and immune responses
- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- RNA and protein synthesis mechanisms
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- RNA Research and Splicing
- RNA modifications and cancer
University of Minnesota
2018-2024
Influenza A virus (IAV) is a respiratory pathogen that has caused significant mortality throughout history and remains global threat to human health. Although much known about IAV replication, the regulation of replication dynamics not completely understood.
Cardiac dysfunction is a common complication of severe influenza virus infection, but whether this occurs due to direct infection cardiac tissue or indirectly through systemic lung inflammation remains unclear. To test the etiology aspect disease, we generated novel recombinant heart-attenuated via genome incorporation target sequences for miRNAs expressed in cardiomyocytes. Compared with control virus, mice infected miR-targeted had significantly reduced heart viral titers, confirming...
Influenza A viruses (IAVs) remain a significant global health burden. Activation of the innate immune response is important for controlling early virus replication and spread. It unclear how IAV events contribute to detection. Additionally, while many cell types in lung can be infected, it not known if all equally establish antiviral state host. Here, we use single-cycle influenza (scIAVs) characterize vitro vivo. We found that magnitude contributes gene expression within infected cells...
Influenza A virus (IAV) remains a global health concern despite the availability of seasonal vaccine. It is difficult to predict which strains will circulate during influenza season, and therefore, it extremely challenging test novel vaccines in human population. To overcome this obstacle, new must be tested challenge studies. This approach poses significant safety problems, since current pharmacological interventions for IAV are poorly efficacious. New methods needed enhance these In study,...
ABSTRACT Zoonotic viruses are an omnipresent threat to global health. Influenza A virus (IAV) transmits between birds, livestock, and humans. Proviral host factors involved in the cross-species interface well known. Less is known about antiviral mechanisms that suppress IAV zoonoses. We observed CpG dinucleotide depletion human relative avian IAV. Notably, ZAP selectively depletes CpG-enriched viral RNAs with its cofactor KHNYN. conserved tetrapods but we uncovered species lack found chicken...
Abstract Cardiac dysfunction is a common extrapulmonary complication of severe influenza virus infection. Prevailing models propose that influenza-associated heart indirectly triggered by cytokine mediated cardiotoxicity downstream the inflamed lung, rather than direct infection cardiac tissue. To test etiology resulting from infection, we generated novel recombinant H1N1 A was attenuated in cardiomyocytes incorporation target sequences for miRNAs expressed specifically cell type (miR133b...