A5082151049- interferon and immune responses
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Literacy, Media, and Education
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Respiratory viral infections research
- Animal Disease Management and Epidemiology
- Zoonotic diseases and public health
- CRISPR and Genetic Engineering
- Clostridium difficile and Clostridium perfringens research
- Immune Response and Inflammation
- Animal Virus Infections Studies
- Gut microbiota and health
- Teacher Education and Leadership Studies
- Global Education and Multiculturalism
- Mosquito-borne diseases and control
- Neuroendocrine regulation and behavior
University of Minnesota
2023-2025
ABSTRACT Specific pathogen-free (SPF) laboratory mice dominate preclinical studies for immunology and vaccinology. Unfortunately, SPF often fail to accurately model human responses vaccination other immunological perturbations. Several groups have taken different approaches introduce additional microbial experience better immune experience. How these models compare is unknown. Here, we directly three models: housing in a microbe-rich barn-like environment (feralizing), adding wild-caught the...
ABSTRACT The bacterial microbiome has a major impact on health and can shape metabolism, host tolerance, immune responses, the outcome of future infections. is highly variable between individuals. Specific pathogen-free animals have reduced diversity, making it difficult to evaluate infection-induced disruption that would be observed in free-living animals, including people. Mice are commonly used as preclinical model but unfortunately often fail predict translation success or failure,...
Influenza viruses pose a significant burden on global human health. has broad cellular tropism in the airway, but how infection of different epithelial cell types impacts replication kinetics and airways is not fully understood. Using primary airway cultures, which recapitulate diverse landscape airways, we investigated impact type composition virus kinetics. Cultures were highly across multiple donors 30 independent differentiation conditions supported range influenza replication. Although...
When a virus crosses from one host species to another, the consequences can be devastating. However, animal models empirically evaluate cross-species transmission fail recapitulate natural routes, physiologically relevant doses of pathogens, and population structures naturally circulating viruses. Here, we present new model where deer mice (
ABSTRACT Zoonotic viruses are an omnipresent threat to global health. Influenza A virus (IAV) transmits between birds, livestock, and humans. Proviral host factors involved in the cross-species interface well known. Less is known about antiviral mechanisms that suppress IAV zoonoses. We observed CpG dinucleotide depletion human relative avian IAV. Notably, ZAP selectively depletes CpG-enriched viral RNAs with its cofactor KHNYN. conserved tetrapods but we uncovered species lack found chicken...