A5022809820- Gut microbiota and health
- Drug Transport and Resistance Mechanisms
- Immune Response and Inflammation
- Animal Behavior and Welfare Studies
- Estrogen and related hormone effects
- Colorectal Cancer Treatments and Studies
- Probiotics and Fermented Foods
- Protein Hydrolysis and Bioactive Peptides
- IL-33, ST2, and ILC Pathways
- Chemotherapy-related skin toxicity
- Ethics in medical practice
- Veterinary medicine and infectious diseases
- Gastrointestinal motility and disorders
- Cancer Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Cardiac Ischemia and Reperfusion
- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
- Human-Animal Interaction Studies
- Helicobacter pylori-related gastroenterology studies
- Eicosanoids and Hypertension Pharmacology
- Barrier Structure and Function Studies
- Proteins in Food Systems
- Immunotherapy and Immune Responses
- NF-κB Signaling Pathways
University of Oslo
2019-2025
Norwegian University of Life Sciences
2020-2025
Østfold Hospital Trust
2025
ABSTRACT Specific pathogen-free (SPF) laboratory mice dominate preclinical studies for immunology and vaccinology. Unfortunately, SPF often fail to accurately model human responses vaccination other immunological perturbations. Several groups have taken different approaches introduce additional microbial experience better immune experience. How these models compare is unknown. Here, we directly three models: housing in a microbe-rich barn-like environment (feralizing), adding wild-caught the...
<h3>Abstract</h3> This most comprehensive analysis to date of γδ T cells in the murine uterus reveals them compose a unique local T-cell compartment. Consistent with earlier reports, expressed canonical Vγ6Vδ1 TCR, and produced interleukin (IL)-17A upon stimulation. Nonetheless, contrasting uterine were not obviously intraepithelial, being more akin sub-epithelial Vγ6Vδ1<sup>+</sup> at several other anatomical sites. By contrast tissues however, compartment also included non-Vγ6<sup>+</sup>,...
ABSTRACT Background Sepsis is associated with myocardial injury and early mortality. The innate immune receptor Toll‐like 4 (TLR4) can recognize pathogen‐associated‐molecular‐patterns (PAMPs) damage‐associated molecular patterns (DAMPs); the latter are released during tissue injury. We hypothesized that TLR4 inhibition reduces proinflammatory signaling cytokine release in: (1) LPS or Escherichia coli ‐treated isolated mouse heart; (2) LPS‐treated primary adult cardiomyocytes; (3) heart...
Abstract Introduction Concerns regarding the translational value of preclinical mouse models have been addressed by introducing various approaches ‘naturalizing’ research mice, which provide them with more diverse microbiomes and physiological immune responses. We previously shown that ‘feralized’ is, inbred laboratory mice raised in a farmyard-like, microbe-rich environment exhibit shifted gut microbiota, matured immunophenotype, reduced severity colorectal cancer. Similar studies...
Living in a farm environment proximity to animals is associated with reduced risk of developing allergies and asthma, has been suggested protect against other diseases, such as inflammatory bowel disease cancer. Despite epidemiological evidence, experimental models that recapitulate environments are needed understand the underlying mechanisms. In this study, we show feralizing conventional inbred mice by continuous exposure livestock farmyard-type conferred protection toward colorectal...
Abstract Background Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide and thus mouse models CRC are significant value to study pathogenesis. The Azoxymethane/Dextran sulfate sodium (AOM/DSS) model a widely used, robust initiation-promotion for chemical induction colitis-associated in rodents. However, dosage chemicals, treatment regimens outcome measures vary greatly among studies employing this model. Thus, aim was examine an AOM/DSS involving reduced (1%)...
To close the gap between ultra-hygienic research mouse models and much more environmentally exposed conditions of humans, we have established a system where laboratory mice are raised under full set environmental factors present in naturalistic, farmyard-type habitat-a process called feralization. In previous studies shown that feralized (Fer) were protected against colorectal cancer when compared to conventionally reared (Lab). However, protective mechanisms remain be elucidated. Disruption...
Laboratory mice are typically housed under extremely clean laboratory conditions, far removed from the natural lifestyle of a free-living mouse. There is risk that this isolation real-life conditions may lead to poor translatability and misinterpretation results. We others have shown feral as well exposed naturalistic environments harbor more diverse gut microbiota display an activated immunological phenotype compared hygienic mice. here describe indoors housing system for mice, representing...
Introduction Avian eggshell membrane (ESM) is a complex extracellular matrix comprising collagens, glycoproteins, proteoglycans, and hyaluronic acid. We have previously demonstrated that ESM possesses anti-inflammatory properties in vitro regulates wound healing processes vivo . The present study aimed to investigate if oral intake of micronized could attenuate skeletal muscle aging associated with beneficial alterations gut microbiota profile reduced inflammation. Methods Elderly male...
The peroxisome proliferator activated receptors (PPARs) are important drug targets in treatment of metabolic and inflammatory disorders. Fibrates, acting as PPARα agonists, have been widely used lipid-lowering agents for decades. However, the currently available targeting show low subtype-specificity consequently a search more potent agonists emerged. In this study, previously isolated oxohexadecenoic acids from marine algae Chaetoceros karianus were to design PPARα-specific analogue. Herein...