A5051712217- Hormonal and reproductive studies
- Chemokine receptors and signaling
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- Pharmacological Effects and Assays
- Renal Diseases and Glomerulopathies
- Pharmacology and Obesity Treatment
- T-cell and B-cell Immunology
- Wound Healing and Treatments
- Neonatal Respiratory Health Research
- Cell death mechanisms and regulation
- Hormonal Regulation and Hypertension
- Cardiovascular Disease and Adiposity
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Anesthesia and Sedative Agents
- Immune Cell Function and Interaction
- Acute Kidney Injury Research
- Drug-Induced Adverse Reactions
- Systemic Lupus Erythematosus Research
- Eicosanoids and Hypertension Pharmacology
- Monoclonal and Polyclonal Antibodies Research
- Blood Pressure and Hypertension Studies
- Sexual Differentiation and Disorders
- Cell Adhesion Molecules Research
- Renal and related cancers
Clarus Therapeutics (United States)
2018-2020
Torrance Memorial Medical Center
2020
Aventura Hospital and Medical Center
2020
University of New Haven
2020
New York Proton Center
2020
University of Pennsylvania
1997-2015
Endo Pharmaceuticals (United States)
2013-2014
GlaxoSmithKline (United States)
2002-2010
GlaxoSmithKline (United Kingdom)
2003-2008
California University of Pennsylvania
2002
Interstitial fibroblasts are principal effector cells of organ fibrosis in kidneys, lungs, and liver. While some view adult tissues as nothing more than primitive mesenchymal surviving embryologic development, they differ from their unique expression fibroblast-specific protein-1 (FSP1). This difference raises questions about origin. Using bone marrow chimeras transgenic reporter mice, we show here that interstitial kidney derive two sources. A small number FSP1(+), CD34(-) migrate to normal...
Interstitial fibroblasts are principal effector cells of organ fibrosis in kidneys, lungs, and liver. While some view adult tissues as nothing more than primitive mesenchymal surviving embryologic development, they differ from their unique expression fibroblast-specific protein-1 (FSP1). This difference raises questions about origin. Using bone marrow chimeras transgenic reporter mice, we show here that interstitial kidney derive two sources. A small number FSP1+, CD34– migrate to normal...
We performed subtractive and differential hybridization for transcript comparison between murine fibroblasts isogenic epithelium, observed only a few novel intracellular genes which were relatively specific fibroblasts. One such gene encodes filament-associated, calcium-binding protein, fibroblast-specific protein 1 (FSP1). The promoter/enhancer region driving this is active in but not mesangial cells or embryonic endoderm. During development, FSP1 first detected by situ after day 8.5 as...
Abstract Background Cardiovascular diseases and their associated risk factors remain the main cause of mortality in western societies. In order to assess prevalence cardiovascular (CVRFs) Caucasian population Lausanne, Switzerland, we conducted a population-based study (Colaus Study). A secondary aim CoLaus will be determine new genetic determinants with CVRFs. Methods Single-center, cross-sectional including random sample 6,188 extensively phenotyped subjects (3,251 women 2,937 men) aged 35...
A seamless plasticity exists among cells shifting between epithelial and mesenchymal phenotypes during early development again later, in adult tissues, following wound repair or organ remodeling response to injury. Fsp1, a gene encoding fibroblast-specific protein associated with cell morphology motility, is expressed epithelial-mesenchymal transformations (EMT) vivo. In the current study, we identified several cytokines that induce Fsp1 cultured cells. combination of these factors, however,...
OBJECTIVE— Pharmacological use of peroxisome proliferator–activated receptor (PPAR)δ agonists and transgenic overexpression PPARδ in mice suggest amelioration features the metabolic syndrome through enhanced fat oxidation skeletal muscle. We hypothesize a similar mechanism operates humans. RESEARCH DESIGN AND METHODS— The agonist (10 mg o.d. GW501516), comparator PPARα (20 μg GW590735), placebo were given double-blind, randomized, three-parallel group, 2-week study to six healthy moderately...
Interstitial fibroblasts are principal effector cells of organ fibrosis in kidneys, lungs, and liver. While some view adult tissues as nothing more than primitive mesenchymal surviving embryologic development, they differ from their unique expression fibroblast-specific protein-1 (FSP1). This difference raises questions about origin. Using bone marrow chimeras transgenic reporter mice, we show here that interstitial kidney derive two sources. A small number FSP1+, CD34– migrate to normal...
Abstract Context A novel formulation of oral testosterone (T) undecanoate (TU) was evaluated in a phase 3 clinical trial. Objective Determine efficacy, short-term safety, and alignment new TU with current US approval standards for T replacement therapy. Design Randomized, active-controlled, open-label study. Setting Patients Academic private practice sites; enrolled patients were clinically hypogonadal men 18 to 65 years old. Methods randomized 3:1 TU, as prescribed (JATENZO®; n = 166) or...
We developed a new mouse model of human anti-glomerular basement membrane (GBM) disease to better characterize the genetic determinants cell-mediated injury. While all major histocompatibility complex (MHC) haplotypes (H-2a, k, s, b, and d) immunized with alpha3 NC1 domains type IV collagen produce anti-alpha3(IV) antibodies that cross-react Goodpasture [anti-GBM/anti-alpha3(IV) NC1] autoantibodies, only few strains nephritis lung hemorrhage associated syndrome. Crescentic glomerulonephritis...
Background. The chemokine receptor, CCR5, and its three high-affinity ligands, macrophage inflammatory protein- (MIP) 1α, MIP-1β, regulated on activation normal T cell expressed secreted (RANTES), are by infiltrating mononuclear cells during the rejection of clinical experimental organ allografts, although significance these molecules in pathogenesis has not been established. Methods. We studied intragraft events four allograft models. First, we cardiac transplants fully MHC-mismatched mice...
Increased blood flow and vascular permeability of early diabetes have been associated with increased nitric oxide formation in diabetic rats, but the specific synthase responsible is unknown. We examined modulation induction activity inducible NOS isoform by high glucose concentration a murine macrophage cell line, RAW 264.7, glomerular mesangial cells. Culturing both types led to significant increases nitrite production mRNA encoding iNOS upon stimulation LPS plus interferon-γ as compared...
Fas ligand (FasL) and belong to a recently described family of cytokines receptors with similarities tumor necrosis factor (TNF) its receptors. Upon engagement by specific antibodies or FasL, transduces signal for apoptosis in permissive cells. Although occurs during renal development following injury mature cells, the factors responsible programmed cell death are uncertain. We have studied expression cells vitro endotoxemia mice. Several types, including glomerular mesangial tubular...
Progressive tissue fibrosis can compromise epithelial function resulting in organ failure. Appreciating evidence suggests that fibroblasts provide fibrogenic collagens during such injury. We further tested this notion by attempting to reduce the physiologic consequences of through selective killing at sites Here, we report conditional reduction using coding sequence for herpesvirus thymidine kinase (ΔTK) put under control a cell-specific promoter from gene encoding fibroblast-specific...
Type IV collagen has recently emerged as a family composed of five known chains (alpha 1-alpha 5), each which contains carboxyl-terminal noncollagenous domain (NC1) approximately 230 amino acids. The NC1 the alpha 3(IV) chain is probable target for autoantibodies in patients with Goodpasture syndrome (GP), evidenced from studies employing bovine type collagen. In present experiments, specificity GP antibodies domains human was determined by using recombinant antigen. cDNAs encoding were...
RANTES is a member of the C-C subfamily chemokines that functions as proinflammatory chemoattractant for CD4+ T cells, monocytes, and eosinophils, an activator basophils to release histamine. Like other members chemokine superfamily, has been implicated in number chronic inflammatory autoimmune processes based on its function pattern regulation. To begin study transcriptional regulation RANTES, we have determined genomic organization gene encoding small inducible cytokine A5 (Scya5)...
Gonadotropin-releasing hormone agonist (GnRHa)-stimulated luteinizing (LH) is the standard hormonal assessment for both diagnosis and therapeutic monitoring of children with central precocious puberty (CPP). Use unstimulated (random) LH levels may be helpful in has gained popularity GnRHa therapy despite lack validation against stimulated values. The objective this investigation was to assess suitability random pubertal suppression during treatment.Data from a multi-year, multicenter,...