Background and Purpose: Peptic ulcer has remained a disease of public health concern. Current therapies are not ideal, necessitating the search for better alternatives. This study evaluated antiulcer property Ricinodendron heudelotii in rats. Methods: Seed oil from R. was extracted subjected to qualitative phytochemical screening. Gas chromatography/ mass spectrometry (GC/MS) performed determine its phytoconstituents. Oral acute toxicity were male Sprague-Dawley The animals pretreated with...

<abstract> <p>The beneficial effects of <italic>Prosopis africana</italic> (PA) on human health have been demonstrated; however, its protective against heavy metals (HM) are not yet understood. This study evaluated the potential neuroprotective PA in cerebral cortex and cerebellum. To accomplish this, we divided 35 albino Sprague Dawley rats into five groups. Group I did receive either metal mixture (HMM) or PA. II received a HMM PbCl<sub>2</sub> (20...

Recently we investigated the heavy metal hazards of Nigerian smokeless tobacco products 'STP'. Since 'STPs' are advocated as safer alternatives to cigarets, public health implication should be ascertained. This is a risk assessment poly aromatic hydrocarbons 'PAHs' in used Nigeria. Thirty from different parts (South East, South West, Niger Delta and North Central) Nigeria were studied. The 15 PAHs assayed using gas chromatographic system (6890 series 6890 plus) equipped with quadrupole Mass...

Heavy metals (HM) are believed to be injurious humans. Man is exposed them on daily basis unknowingly, with no acceptable protocol manage its deleterious effects. These occur as mixture of chemicals varying concentrations in our atmosphere. There growing calls for the use essential mitigating effects induced by heavy exposure man; therefore, aim this study was evaluate protective (Zinc and Selenium) a metal toxicity. In study, except negative controls, all other groups were treated lead...

The high rate of male infertility and the meargre resources to manage same in sub Saharan Africa have necessitated search for cost effective available alternatives. Mushrooms been used traditionally folk medicine as nutraceuticals. This study has investigated effect wild mushroom Pleurotus tuber-regium on carbon tetrachloride (CCl4) deleterious effects reproductive system rats. Thirty six rats were divided into groups animals each. Group I (negative control) received 10ml/kg olive oil...

Interest is rising in smokeless tobacco as a safer alternative to smoking. Information on the heavy metal hazards of sparse Nigeria, it most sub-Saharan Africa countries. This study assesses types commonly available Nigeria.Using market basket protocol 30 Nigerian were studied. Digestion was performed by addition 10 mL mix nitric and hydrochloric acids (HCl:HNO3, 3:1); mixture then heated dryness. Then, 20 deionised water added, stirred filtered. The filtrate made up standard volumetric...

Abstract Background Terminalia superba is a well-known medicinal plant used in folk medicine for the management of various diseases and swelling. Validation its efficacy standardized scientific models lacking. This gap needs to be filled as way enhancing modern drug discovery. The aim evaluate antibacterial, antioxidant, anti-inflammatory properties T. known established models. Also, establish possibly correlate activity with phytochemicals identified using GC/MS qualitative methods. Results...

Male fertility is strongly affected by the overexpression of free radicals induced heavy metals. The aim this study was to evaluate potential antioxidant, anti-inflammatory, and gonado-protective effects natural compounds. Biochemical morphological assays were performed on male albino rats divided into five groups: a control group (water only), orally exposed metal mixture Pb-Cd-Hg-As alone three groups co-administered an aqueous extract Nigerian medicinal plant, Anonychium africanum...

Chronic kidney disease is a health burden worldwide but particularly in sub-Saharan Africa, with dwindling resources as result of poor commodity export, devaluation currencies, and corruption that had decreased the average family income substantially increased number persons living on less than $1.90/day. Natural products are part healthcare delivery system world. This study was conducted to evaluate protective effects Pleurotus tuber-regium kidneys rats treated carbon tetrachloride (CCl4)...

The incidence of male infertility arising from sexual dysfunction is high especially in the sub saharan Africa. African foods may hold promise to reverse this trend. aim study therefore evaluate improvement reproductive and testicular injuries mediated by CCl4 use a wild edible mushroom, P. tuber-regium. Sixty rats were divide into six groups. Group I received 3 mL/kg olive oil intraperitoneal injections twice weekly. II (30% oil) injected weekly i.p, Groups III, IV V 100 mg, 200 mg 500...

The economic cost of and liver kidney diseases in Sub Saharan Africa remain prohibitive, hence the quest for medicinal foods that can reverse hepato-renal damages. aim this study is to investigate protective effect wild edible P.tuber-regium on carbon tetrachloride (CCl4) induced oxidative stress male Sprague–Dawley rats. Thirty six rats were divided into groups animals each. Group I (negative control) received 10 ml/kg olive oil intraperitoneal weekly addition feed water ad libitum. II...

This study has characterized the phytoconstituents and evaluated in vitro antioxidant hepatoprotective effects of Pleurotus tuber-regium induced by carbon tetrachloride (CCl4). In assay ethanol extract P. gas chromatography-mass spectrometry analyses to identify were carried out.Sixty rats divided into six groups 10 animals each group treated as follows for 13 weeks. Group I (control) received 3 mL/kg olive oil intraperitoneal twice weekly addition feed water ad libitum. II CCl4 weekly....

The aim of this work was to evaluate the hepatoprotective potential fractions and phytosomal complexes Telfairia occidentalis leaf extracts on ethanol-induced hepatotoxicity in rat models. Phytosomal ethanol extract were prepared by thin film hydration technique. Hepatoprotective activities evaluated biochemical assays histopathological examination liver sections. Intoxication animals with pure significantly (p < 0.05) elevated their enzyme titers, whereas co-administration various...

Anaemia is a leading cause of morbidity and mortality in both males females all ages. was induced by intraperitoneal (i.p.) administration phenylhydrazine (60 mg/kg) for period 3 days. Anaemic rats were allotted to five (5) groups; group I served as the negative control, II positive control received Astyfer syrup (0.15 mg/kg p.o) , groups III-V test that Tapinanthus globiferus methanol extract, ethyl acetate n-hexane fractions (100, 200 400 mg/kg, p.o.), respectively. Packed cell volume...

African mesquite AM is widely used as an anti-inflammatory agent in sub-Sahara Africa especially Nigeria. Given its strong potency, this study has evaluated the neuroprotective properties of hippocampus HIP and olfactory bulb OB rats exposed to Cd, As, Hg, Pb. Twenty-five albino Sprague Dawley were randomly divided into five groups experiment. Group 1, control received only water. 2 heavy metal mixture HMM (PbCl

Aim: This study aimed to compare the oral pharmacokinetics of different paediatric paracetamol dosage forms that are commercially available in Nigeria. Study Design: Experimental. Place and Duration Study: Faculty Pharmaceutical Sciences, Enugu State University Science Technology, between March December 2023 Methodology: The used regular vitro dialysis membrane method predict vivo drug release syrups (n=5) dispersible tablets Nigerian market. sink condition followed Conventional USP...

In Nigeria, traditional medicinal plants are often use to relieve pain and inflammation. Traditional healers in Nigeria folk medicine herbs like P. africanum (P.beauv) The current work sought investigate the analgesic anti-inflammatory properties of methanol crude extract fractions aerial part animal models. Extraction was accomplished through successive maceration with solvents increasing polarity: methanol, n-hexane, butanol. Following extraction, were tested for central activity using...

Abstract Pleurotus tuber regium , a wild edible mushroom can reduce free radical-mediated injury and oxidative stress induced by carbon tetrachloride (CCl 4 ) via improvement of antioxidant capacity. This work evaluates the protective effects this against metabolic hematological toxicity CCl . Sixty male Sprague Dawley rats were divided into six groups (n = 10). Group I received olive oil (3 mL/kg) i.p. twice weekly for 13 weeks, while maintaining access to food water ad libitum (negative...