A5016933947- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Aluminum toxicity and tolerance in plants and animals
- Heavy metals in environment
- Bone health and osteoporosis research
- Hip disorders and treatments
- Iron Metabolism and Disorders
- Orthopaedic implants and arthroplasty
- Alzheimer's disease research and treatments
- Pharmacological Effects of Medicinal Plants
- Bone and Joint Diseases
- Nanoparticles: synthesis and applications
- Hip and Femur Fractures
- Neurological Disease Mechanisms and Treatments
- Selenium in Biological Systems
- Curcumin's Biomedical Applications
- Medicinal Plants and Neuroprotection
- Shoulder Injury and Treatment
- Vitamin C and Antioxidants Research
- Shoulder and Clavicle Injuries
- Erythropoietin and Anemia Treatment
- Drug-Induced Hepatotoxicity and Protection
- Neuroscience and Neuropharmacology Research
- Orthopedic Surgery and Rehabilitation
- Immunotoxicology and immune responses
University of Belgrade
2020-2025
Institut za Reumatologiju
2023
The hippocampus executes the integration of memory and spatial learning information. This study evaluated effect rice bran extract (RBE) on heavy metal mixture (MM) induced hippocampal toxicity its underlying mechanism in albino rats. Thirty five rats were exposed to MM alone at Pb 20 mg/kg, Al 35 Mn 0.564 mg/kg body weight or co-exposed with RBE 125, 250 500 weight, 125 b.wt only, only 5 days a wk for 13 (90 days). Subsequently, oxidative stress, inflammation (cyclooxygenase-2) caspase-3,...
<abstract> <p>The beneficial effects of <italic>Prosopis africana</italic> (PA) on human health have been demonstrated; however, its protective against heavy metals (HM) are not yet understood. This study evaluated the potential neuroprotective PA in cerebral cortex and cerebellum. To accomplish this, we divided 35 albino Sprague Dawley rats into five groups. Group I did receive either metal mixture (HMM) or PA. II received a HMM PbCl<sub>2</sub> (20...
Zinc (Zn) is the second most abundant metal in human body, and essential for function of 10% all proteins. As metals cannot be synthesized or degraded, they must assimilated from diet by specialized transport proteins, which unfortunately also provide an entry route toxic pollutant cadmium (Cd). The intestinal absorption Zn depends on composition food that consumed, firstly amount itself, then quantity other constituents such as phytate, protein calcium (Ca). In cells, involved regulation...
Heavy metals (HM) are believed to be injurious humans. Man is exposed them on daily basis unknowingly, with no acceptable protocol manage its deleterious effects. These occur as mixture of chemicals varying concentrations in our atmosphere. There growing calls for the use essential mitigating effects induced by heavy exposure man; therefore, aim this study was evaluate protective (Zinc and Selenium) a metal toxicity. In study, except negative controls, all other groups were treated lead...
Hippocampus is the brain area where aluminum (Al) accumulates in abundance and widely associated with learning memory. In present study, we evaluate behavioral, tissue, proteomic changes hippocampus of Wistar rats caused by exposure to doses that mimic human consumption chloride (AlCl3) urban areas. For this, male were divided into two groups: Control (distilled water) AlCl3 (8.3 mg/kg/day), both groups exposed orally for 60 days. After Al protocol, cognitive functions assessed Water maze...
Zinc (Zn) is the second most abundant metal in human body and essential for function of 10% all proteins. As metals cannot be synthesized or degraded, they must assimilated from diet by specialized transport proteins, which unfortunately also provide an entry route toxic pollutant cadmium (Cd). The intestinal absorption Zn depends on composition food that consumed, firstly amount itself then quantity other constituents such as phytate, protein, calcium (Ca). In cells, involved regulation...
This study evaluated the potential protective effects of Zn and Se in cerebellum cerebral cortex, two fundamentally important brain regions, albino rats that were exposed to heavy metals mixture (Al, Pb, Hg Mn).
The extent of heavy-metal-induced cardiotoxicity is proportional to the levels metal bioaccumulation, and it was previously assumed that heavy metals accumulate uniformly in myocardium. Therefore, aim this study investigate concentrations metalloids two distant regions left ventricle (LV), base LV, apex LV using inductively coupled plasma mass spectrometry (ICP-MS). We also examined potential correlation between thickness interventricular septum twenty specimens (ten from ten LV) 10...
This study evaluated nickel and aluminium-induced neurotoxicity, as a binary metal mixture. Twenty-eight male Sprague Dawley albino rats were weight-matched divided into four groups. Group 1 (control) received deionized water. 2 3 Aluminium (1 mg/kg) Nickel (0.2 respectively, while 4 Ni Al mixture HMM three times week orally for 90 days. Barnes maze tests was performed. Rats sacrificed under pentobarbital anaesthesia, cerebral cortex hippocampus separated, levels measured using Atomic...
Introduction and aim. This is an evaluation of the protective effects Zn Se in eye thymus rats exposed to cock tail noxious metal mixtures (CNMM) (Al, Pb, Hg Mn) ameliorating ocular pathologies due autoimmunity. Material methods. Female Sprague were grouped into eight (n=5) orally various treatments for a period 60 days: (1): control group receive deionized water only; (2): CNMM only received lead acetate Pb(C2H3O2)2 (20 mg/kg), AlCl3 (35 HgCl2 (0.40 mg/kg) MnCl2 (0.56 mg/kg); (3)...