A5017367749- Human-Animal Interaction Studies
- Primate Behavior and Ecology
- Animal Genetics and Reproduction
- Genomics and Phylogenetic Studies
- Genetic Mapping and Diversity in Plants and Animals
- Neuroendocrine regulation and behavior
- Genetic diversity and population structure
- Retinal Development and Disorders
- Genetic and phenotypic traits in livestock
- Chromosomal and Genetic Variations
- Wildlife Ecology and Conservation
- Rabies epidemiology and control
- Animal Behavior and Welfare Studies
- Microbial infections and disease research
- Connexins and lens biology
- Connective tissue disorders research
- Genomics and Chromatin Dynamics
- Veterinary Oncology Research
- Virus-based gene therapy research
- melanin and skin pigmentation
- Glaucoma and retinal disorders
- dental development and anomalies
- Bacteriophages and microbial interactions
- Veterinary Orthopedics and Neurology
- Adipose Tissue and Metabolism
University of Illinois Urbana-Champaign
2015-2024
University of Copenhagen
2024
University of Illinois System
2024
Zhejiang University
2024
Institute of Cytology and Genetics
2009-2017
University of California, Davis
2017
National Institute on Alcohol Abuse and Alcoholism
2017
National Institutes of Health
2017
Cornell University
2003-2013
Institut de génétique et de développement de Rennes
2009
The features of modern dog breeds that increase the ease mapping common diseases, such as reduced heterogeneity and extensive linkage disequilibrium, may also difficulty associated with fine identifying causative mutations. One way to address this problem is by combining data from multiple segregating same trait after initial has been determined. multibreed approach increases number potentially informative recombination events reduces size critical haplotype taking advantage shortened...
Abstract Strains of red fox ( Vulpes vulpes ) with markedly different behavioural phenotypes have been developed in the famous long-term selective breeding programme known as Russian farm-fox experiment. Here we sequenced and assembled genome re-sequenced a subset foxes from tame, aggressive conventional farm-bred populations to identify genomic regions associated response selection for behaviour. Analysis genomes identified 103 either significantly decreased heterozygosity one three or...
Significance The behavior of domesticated animals differs dramatically from that wild relatives, and the Russian tame fox experiment demonstrated clearly these changes can occur in just a few generations selection. Analysis gene expression brains aggressive foxes this allows us to ask what brain pathways have been altered by recent, strong Pathways impact function both serotonergic glutaminergic neurons were modulated selection, consistent with roles learning memory. Both allele frequency...
The foxes at Novosibirsk, Russia, are the only population of domesticated in world. These originated from farm-bred silver (Vulpes vulpes), whose genetic source is unknown. In this study we examined origin strain and two other fox populations (aggressive unselected) maintained Novosibirsk. To identify phylogenetic these sequenced regions mtDNA, cytochrome b D-loop, 24 Novosibirsk (8 each population) compared them with corresponding sequences native red Europe, Asia, Alaska Western Canada,...
The role of chromosome rearrangements in driving evolution has been a long-standing question evolutionary biology. Here we focused on ruminants as model to assess how may have contributed the gene regulation. Using reconstructed ancestral karyotypes Cetartiodactyls, Ruminants, Pecorans, and Bovids, traced patterns gross changes. We found that lineage leading ruminant ancestor after split from other cetartiodactyls was characterized by mostly intrachromosomal changes, whereas pecoran...
Two strains of the silver fox (Vulpes vulpes), with markedly different behavioral phenotypes, have been developed by long-term selection for behavior. Foxes from tame strain exhibit friendly behavior towards humans, paralleling sociability canine puppies, whereas foxes aggressive are defensive and aggression to humans. To understand genetic differences underlying these phenotypes fox-specific genomic resources needed.cDNA mRNA pre-frontal cortex a an was sequenced using Roche 454 FLX...
There is a growing body of evidence that B chromosomes, once regarded as totally heterochromatic and genetically inert, harbor multiple segmental duplications containing clusters ribosomal RNA genes, processed pseudogenes protein-coding genes. Application novel molecular approaches further supports complex composition possible phenotypic effects chromosomes.Here we review recent findings gene-carrying genomic segments on chromosomes from different vertebrate groups. We demonstrate the...
The silver fox (Vulpes vulpes) offers a novel model for studying the genetics of social behavior and animal domestication. Selection foxes, separately, tame aggressive has yielded two strains with markedly different, genetically determined, behavioral phenotypes. Tame strain foxes are eager to establish human contact while from difficult handle. These have been maintained as separate outbred lines over 40 generations but their genetic structure not previously investigated. We applied...
A meiotic linkage map is essential for mapping traits of interest and often the first step toward understanding a cryptic genome. Specific strains silver fox (a variant red fox, Vulpes vulpes ), which segregate behavioral morphological phenotypes, create need such map. One strain, selected docility, exhibits friendly dog-like responses to humans, in contrast another strain aggression. Development facilitated by known cytogenetic homologies between dog availability high resolution canine...
Domesticated species exhibit a suite of behavioral, endocrinological, and morphological changes referred to as "domestication syndrome." These may include reduction in reactivity the hypothalamic-pituitary-adrenal (HPA) axis specifically reduced adrenocorticotropic hormone release from anterior pituitary. To investigate biological mechanisms targeted during domestication, we investigated gene expression pituitaries experimentally domesticated foxes (Vulpes vulpes). RNA was sequenced...
<title>Abstract</title> Domestication represents one of the largest biological shifts life on Earth, and for many animal species, behavioral selection is thought to facilitate early stages process. The gut microbiome animals can respond environmental changes have diverse powerful effects host behavior. As such, we hypothesize that tame behavior during domestication, may indirectly selected certain microbiota contribute plasticity necessary adapt new social environment. Here, explore foxes...
The silver fox, a variant of the red fox (Vulpes vulpes), is close relative dog (Canis familiaris). Cytogenetic differences and similarities between these species are well understood, but their genomic organizations have not been compared at higher resolution. Differences in behavior also remain unexplained. Two strains demonstrating markedly different generated Institute Cytology Genetics Russian Academy Sciences. Foxes selected for tameness friendly, like domestic dogs, while foxes...
The underlying neurological events accompanying dog domestication remain elusive. To reconstruct the process in an experimental setting, silver foxes (Vulpes vulpes) have been deliberately bred for tame vs aggressive behaviors more than 50 generations at Institute Cytology and Genetics Novosibirsk, Russia. hypothalamus is essential part of hypothalamic-pituitary-adrenal axis regulates fight-or-flight response, thus, we hypothesized that selective breeding tameness/aggressiveness has shaped...
The Russian farm-fox experiment is an unusually long-running and well-controlled study designed to replicate wolf-to-dog domestication. As such, it offers unprecedented window onto the neural mechanisms governing evolution of behavior. Here we report evolved changes gray matter morphology resulting from selection for tameness versus aggressive responses toward humans in a sample 30 male fox brains. Contrasting with standing ideas on effects domestication brain size, tame foxes did not show...
Achromatopsia is an autosomal recessive disease characterized by the loss of cone photoreceptor function that results in day-blindness, total colorblindness, and decreased central visual acuity. The most common causes for are mutations CNGB3 gene, coding beta subunit cyclic nucleotide-gated channels cones. CNGB3-achromatopsia, or degeneration (cd), also known to occur two canine breeds, Alaskan malamute (AM) German shorthaired pointer.Here we report in-depth characterization achromatopsia...
The phenomenon of a remarkable conservation the X chromosome in eutherian mammals has been first described by Susumu Ohno 1964. A notable exception is cetartiodactyl chromosome, which varies widely morphology and G-banding pattern between species. It hypothesized that this sex undergone multiple rearrangements changed centromere position order syntenic segments over last 80 million years Cetartiodactyla speciation. To investigate its evolution we have selected 26 evolutionarily conserved...