A5000701113- Human-Animal Interaction Studies
- Advanced Radiotherapy Techniques
- Retinal Development and Disorders
- Genetic diversity and population structure
- Primate Behavior and Ecology
- Genomics and Phylogenetic Studies
- Animal Genetics and Reproduction
- Wildlife Ecology and Conservation
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Genetic and phenotypic traits in livestock
- Chromosomal and Genetic Variations
- Genetic Mapping and Diversity in Plants and Animals
- Prostate Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Connexins and lens biology
- Advanced X-ray and CT Imaging
- Fish Ecology and Management Studies
- Animal Behavior and Welfare Studies
- dental development and anomalies
- Connective tissue disorders research
- Rabies epidemiology and control
- Adipose Tissue and Metabolism
- Reproductive biology and impacts on aquatic species
- Effects and risks of endocrine disrupting chemicals
University of Illinois Urbana-Champaign
2015-2024
United States Fish and Wildlife Service
1983-2021
Scripps Research Institute
1992-2019
Shawnee Mission Medical Center
2019
Southwestern Medical Center
2018
The University of Texas Southwestern Medical Center
2018
Institute of Cytology and Genetics
2009-2017
University of California, Davis
2000-2017
National Institute on Alcohol Abuse and Alcoholism
2017
National Institutes of Health
2017
NK cells have therapeutic potential for a wide variety of human malignancies. However, because expand poorly in vitro, limited life spans vivo, and represent small fraction peripheral white blood cells, obtaining sufficient cell numbers is the major obstacle NK-cell immunotherapy. Genetically-engineered artificial antigen-presenting (aAPCs) expressing membrane-bound IL-15 (mbIL15) been used to propagate clinical-grade trials adoptive immunotherapy, but ex vivo proliferation has by telomere...
Abstract Strains of red fox ( Vulpes vulpes ) with markedly different behavioural phenotypes have been developed in the famous long-term selective breeding programme known as Russian farm-fox experiment. Here we sequenced and assembled genome re-sequenced a subset foxes from tame, aggressive conventional farm-bred populations to identify genomic regions associated response selection for behaviour. Analysis genomes identified 103 either significantly decreased heterozygosity one three or...
Significance The behavior of domesticated animals differs dramatically from that wild relatives, and the Russian tame fox experiment demonstrated clearly these changes can occur in just a few generations selection. Analysis gene expression brains aggressive foxes this allows us to ask what brain pathways have been altered by recent, strong Pathways impact function both serotonergic glutaminergic neurons were modulated selection, consistent with roles learning memory. Both allele frequency...
The foxes at Novosibirsk, Russia, are the only population of domesticated in world. These originated from farm-bred silver (Vulpes vulpes), whose genetic source is unknown. In this study we examined origin strain and two other fox populations (aggressive unselected) maintained Novosibirsk. To identify phylogenetic these sequenced regions mtDNA, cytochrome b D-loop, 24 Novosibirsk (8 each population) compared them with corresponding sequences native red Europe, Asia, Alaska Western Canada,...
During the course of our analysis fish and other aquatic materials for pesticide residues, unknown components were often detected.Concern about identity late eluting gas-liquid chromatographic (GLC) peaks in water extracts led to identification phthalic acid esters (PAEs) as environmental contaminants (1).Further study these with a GLC-mass spectrometer (GLC-MS) their di-2-ethylhexyl phtha- (DEHP) di-n-butyl phthalate (DBP).Preliminary data from acute toxicity tests indicate that compounds...
The role of chromosome rearrangements in driving evolution has been a long-standing question evolutionary biology. Here we focused on ruminants as model to assess how may have contributed the gene regulation. Using reconstructed ancestral karyotypes Cetartiodactyls, Ruminants, Pecorans, and Bovids, traced patterns gross changes. We found that lineage leading ruminant ancestor after split from other cetartiodactyls was characterized by mostly intrachromosomal changes, whereas pecoran...
Two strains of the silver fox (Vulpes vulpes), with markedly different behavioral phenotypes, have been developed by long-term selection for behavior. Foxes from tame strain exhibit friendly behavior towards humans, paralleling sociability canine puppies, whereas foxes aggressive are defensive and aggression to humans. To understand genetic differences underlying these phenotypes fox-specific genomic resources needed.cDNA mRNA pre-frontal cortex a an was sequenced using Roche 454 FLX...
The silver fox (Vulpes vulpes) offers a novel model for studying the genetics of social behavior and animal domestication. Selection foxes, separately, tame aggressive has yielded two strains with markedly different, genetically determined, behavioral phenotypes. Tame strain foxes are eager to establish human contact while from difficult handle. These have been maintained as separate outbred lines over 40 generations but their genetic structure not previously investigated. We applied...
A meiotic linkage map is essential for mapping traits of interest and often the first step toward understanding a cryptic genome. Specific strains silver fox (a variant red fox, Vulpes vulpes ), which segregate behavioral morphological phenotypes, create need such map. One strain, selected docility, exhibits friendly dog-like responses to humans, in contrast another strain aggression. Development facilitated by known cytogenetic homologies between dog availability high resolution canine...
Domesticated species exhibit a suite of behavioral, endocrinological, and morphological changes referred to as "domestication syndrome." These may include reduction in reactivity the hypothalamic-pituitary-adrenal (HPA) axis specifically reduced adrenocorticotropic hormone release from anterior pituitary. To investigate biological mechanisms targeted during domestication, we investigated gene expression pituitaries experimentally domesticated foxes (Vulpes vulpes). RNA was sequenced...
Abstract The purpose of this experiment was to investigate the welfare pregnant mares kept in straight stalls and given only limited exercise, conditions that are similar those encountered mare urine industry. Sixteen (eight each two years) were randomly assigned groups: Ex (exercised a paddock for 30 min per day) or NoEx one period every 14 days). horses housed (or ‘tie’) six months had ad libitum access grass hay. Each horse's behaviour recorded on videotape once week 24 h. major...