A5085371544- Adolescent and Pediatric Healthcare
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Complement system in diseases
- HIV Research and Treatment
- BRCA gene mutations in cancer
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Lipid Membrane Structure and Behavior
- Pregnancy and preeclampsia studies
- Child and Adolescent Psychosocial and Emotional Development
- Diet and metabolism studies
- Advanced biosensing and bioanalysis techniques
- Maternal Mental Health During Pregnancy and Postpartum
- Electroconvulsive Therapy Studies
- Health, Environment, Cognitive Aging
- Attention Deficit Hyperactivity Disorder
- Cognitive Abilities and Testing
University of Gothenburg
2021-2025
Sahlgrenska University Hospital
2023-2024
Cardiff University
2024
Medical Research Council
2024
Centre for Mental Health
2024
Abstract Postsynaptic density is reduced in schizophrenia, and risk variants increasing complement component 4A ( C4A ) gene expression are linked to excessive synapse elimination. In two independent cohorts, we show that cerebrospinal fluid (CSF) concentration elevated patients with first-episode psychosis (FEP) who develop schizophrenia (FEP-SCZ: median 0.41 fmol/ul [CI = 0.34–0.45], FEP-non-SCZ: 0.29 0.22–0.35], healthy controls: 0.28 0.24–0.33]). We the CSF elevation of FEP-SCZ exceeds...
Many but not all persons with bipolar disorder require hospital care because of severe mood episodes. Likewise, some patients experience long-term occupational dysfunction that extends beyond acute It is known whether these dissimilar outcomes are driven by different polygenic profiles. Here, scores (PGSs) for major psychiatric disorders and educational attainment were assessed associations functioning admissions in disorder.
Recent evidence has implicated complement component (C) 4A in excessive elimination of synapses schizophrenia. C4A is believed to contribute physiological synapse removal through signaling within the C1q initiated classical activation axis system. So far, a potential involvement pathophysiology schizophrenia remains unclear. In this study, we first utilized large-scale gene expression datasets (n = 586 patients with and n 986 controls) observe lower C1QA mRNA prefrontal cortex tissue...
Bipolar disorder is a severe psychiatric syndrome defined by periodic mood shifts. Patients with bipolar show cognitive impairments relative to healthy controls. The risk of developing schizophrenia, and partially also disorder, has previously been shown increase lower premorbid intelligence. It not known if intelligence associated level functioning illness severity people having developed disorder. We used multiple linear ordinal regression analyze how intelligence, as measured at...
The genetic overlap between schizophrenia (SZ) and bipolar disorder (BD) is substantial. Polygenic risk scores have been shown to dissect different symptom dimensions within across these two disorders. Here, we focused on the most strongly associated SZ locus located in extended MHC region, which largely explained by copy numbers of gene coding for complement component 4A (C4A). First, utilized existing brain tissue collections (N = 1,202 samples) observed no altered C4A expression BD...
Introduction Postpartum psychosis is a rare psychiatric emergency, occurring days to weeks after 1-2 per 1000 deliveries. Its low prevalence makes it difficult recruit enough participants investigate the underlying pathophysiology. It epidemiologically linked bipolar disorder, which one study also found resemble in genetic susceptibility for disorders (Di Florio et al . Lancet Psych 2021; 8: 1045–52). Objectives In this we aim polygenic liability two new Swedish postpartum cohorts. Methods...
Abstract Excessive synapse loss is a core feature of schizophrenia and linked to the complement component 4A gene ( C4A ). In two independent cohorts, we show that cerebrospinal fluid (CSF) concentration elevated in first-episode psychosis patients who develop correlates with CSF measurements density. Using patient-derived cellular modeling, find disease-associated cytokines increase neuronal expression IL-1β associates CSF.