A5071257793- Spondyloarthritis Studies and Treatments
- Osteoarthritis Treatment and Mechanisms
- Inflammasome and immune disorders
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Dermatological and Skeletal Disorders
- Bone and Joint Diseases
- Total Knee Arthroplasty Outcomes
- Cancer-related molecular mechanisms research
- Psoriasis: Treatment and Pathogenesis
- Extracellular vesicles in disease
- Heterotopic Ossification and Related Conditions
- Lower Extremity Biomechanics and Pathologies
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammation biomarkers and pathways
Changhai Hospital
2020-2024
Second Military Medical University
2020-2024
Objective: Osteoarthritis (OA) is the most prominent chronic arthritic disease, affecting over 3 billion people globally.Synovial macrophages, as immune cells, play an essential role in cartilage damage OA.Therefore, regulating macrophages crucial for controlling pathological changes OA.Triggering receptor expressed on myeloid cells 2 (TREM2), cell surfaces, such and dendritic has suppressed inflammation regulated M2 macrophage polarization but demonstrated unknown synovial OA.This study...
Ankylosing spondylitis (AS) is an autoimmune disease with a genetic correlation and characterized by inflammation in the axial skeleton sacroiliac joints. Many AS patients also have inflammatory bowel diseases (IBD), but underlying causes of intestinal osteoporosis are not well understood. CX3CL1, protein involved inflammation, has been found to be up-regulated AS-model mice.The authors investigated effects CX3CL1 on studying its impact macrophage polarization, factors, osteoclast...
ObjectiveChondrocyte death is the hallmark of cartilage degeneration during osteoarthritis (OA). However, specific pathogenesis cell in OA chondrocytes has not been elucidated. This study aims to validate role CDKN1A, a key programmed (PCD)-related gene, chondrogenic differentiation using combination single-cell and bulk sequencing approaches.DesignOA-related RNA-seq data (GSE114007, GSE55235, GSE152805) were downloaded from Gene Expression Omnibus database. PCD-related genes obtained...
Ankylosing spondylitis (AS) is a chronic, progressive, and inflammatory disease that mainly affects the central axis joint. Although this has already been well documented studied, its pathogenesis still not understood. This study aimed to screen identify key candidate genes involved in progression of AS. For purpose, expression profiles GSE39340 GSE41038 were downloaded from Gene Expression Omnibus displayed form volcano plots heatmaps. Differentially expressed (DEGs) identified by Limma...
Ankylosing spondylitis (AS) is a rheumatic bone and joint disease caused by inflammation, erosion, pathological formation. The features of chronic destruction, ossification occur due to the disruption body's immune regulation altered remodeling balance. Mesenchymal stem cells (MSCs) have multidirectional differentiation potential immunomodulatory functions play an important role in osteogenic capacity MSCs AS are factors such as genetic background, internal environment, infection, mechanical...
Objective Axial spondyloarthritis (axSpA) is a chronic rheumatic disease predominantly characterized by inflammation and progressive structural damage. Patients are often diagnosed very late, which delays the optimal treatment period. Early diagnosis of axSpA, especially non-radiographic axSpA (nr-axSpA), remains major challenge. This study aimed to investigate diagnostic value anti-Kaiso autoantibodies in their correlation with clinical indicators. Methods Two pooled serum samples (seven...