A5073373194- Hemoglobinopathies and Related Disorders
- Pain Mechanisms and Treatments
- Ginseng Biological Effects and Applications
- Endoplasmic Reticulum Stress and Disease
- Veterinary Pharmacology and Anesthesia
- Hemoglobin structure and function
- Heat shock proteins research
- Neurobiology and Insect Physiology Research
- Gut microbiota and health
- Stress Responses and Cortisol
- Erythrocyte Function and Pathophysiology
Medical College of Wisconsin
2023-2024
Few analgesics identified using preclinical models have successfully translated to clinical use. These translational limitations may be due the unidimensional nature of behavioral response measures used assess rodent nociception. Advances in high-speed videography for pain behavior allow objective quantification nuanced aspects evoked paw withdrawal responses. However, whether videography-based assessments mechanical hypersensitivity outperform traditional measurement reproducibility is...
Abstract Pain is a debilitating symptom and leading reason for hospitalization of individuals with sickle cell disease. Chronic pain poorly managed because the biological basis not fully understood. Using transgenic mice fecal material transplant, we determined that gut microbiome drives persistent pain. In parallel patient mouse analyses, identified bilirubin as one metabolite induces by altering vagus nerve activity. Furthermore, decreased abundance bacteria Akkermansia mucinophila...