A5011028952- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Spectroscopy and Chemometric Analyses
- Advanced Chemical Sensor Technologies
- Antibiotics Pharmacokinetics and Efficacy
- Computational Drug Discovery Methods
- Biochemical Analysis and Sensing Techniques
- Drug Transport and Resistance Mechanisms
- Drug Solubulity and Delivery Systems
- Pharmacological Effects and Assays
- Analytical chemistry methods development
- Advanced Drug Delivery Systems
- Pharmaceutical studies and practices
- Mass Spectrometry Techniques and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Protein purification and stability
- Protein Interaction Studies and Fluorescence Analysis
- Mesoporous Materials and Catalysis
- Additive Manufacturing and 3D Printing Technologies
- Crystallization and Solubility Studies
- Pesticide Residue Analysis and Safety
- Chromatography in Natural Products
- Tea Polyphenols and Effects
- Spectroscopy Techniques in Biomedical and Chemical Research
- 3D Printing in Biomedical Research
Aristotle University of Thessaloniki
2014-2025
Telio (Norway)
2009
Foundation for Research and Technology Hellas
2008
University of Patras
2008
Combination therapy has been conferred with manifold assets leveraging the synergy of different agents to achieve a sufficient therapeutic outcome lower administered drug doses and reduced side effects. The potency self-assembling peptide hydrogel for co-delivery doxorubicin curcumin was assessed against head neck cancer cells. dual loaded enabled control over rate release based on drug's aqueous solubility. A significantly enhanced cell growth inhibitory effect observed after treatment...
A pressure ulcer is the necrosis of skin and tissues due to prolonged pressure. Its prevention treatment are great importance not only for health but also patient’s quality life considered highest priority. In present study, a reliable analytical method developed quantitative determination panthenol, hesperidin, rutin, allantoin by HPLC UV detectors. The substances were formulated into pharmaceutical gel, with healing regenerative properties recommended first- second-degree bedsores. Their...
Encapsulation of poorly water-soluble drugs into mesoporous materials (e.g. silica) has evolved as a favorable strategy to improve drug solubility and bioavailability. Several techniques spray drying, solvent evaporation, microwave irradiation) have been utilized for the encapsulation active pharmaceutical ingredients (APIs) inorganic porous matrices. In present work, novel chalcone (KAZ3) with anticancer properties was successfully synthesized by Claisen-Schmidt condensation. KAZ3 loaded...
The undeniable value of sleep is commonly accepted and essential for all aspects human existence. aim the present study was to develop validate an applicable sensitive HPLC-FLD method quantitative determination pyridoxine (PYR) melatonin (MEL) in a chocolate formulation that suitable treatment insomnia. proposed chromatographic process performed on Aqua column (250 mm × 4.6 mm, 5 mm) at 45 °C, with mobile phase consisting two solvents (A, water 0.2% formic acid; B, acetonitrile acid)...
Abstract A liquid chromatography/tandem mass spectrometry (LC‐MS/MS) method, characterized by complete automation and high‐throughput, was developed for the determination of colistin B in human plasma. All sample preparation procedures were performed using 2.2 mL 96‐deep‐well plates, whereas robotic liquid‐handling workstations utilized all transfer steps, including solid‐phase extraction (SPE). The whole procedure very rapid, method had a short chromatographic run time just 2 min. Sample...
The signal intensity in electrospray ionization mass spectrometry (ESI-MS) positive mode is affected by parameters that are related to the physicochemical properties and structural features of a molecule. Accordingly, combined interactions an analyte mobile phase used still area demands further clarifications since there no general pattern regarding nature molecule mechanism which vapor-phase ions produced.A multivariate analysis method, such as Partial Least Squares (PLS), provides...
Oxidative stress degrades skin collagen and elastin causes inflammatory reactions that affect mitochondrial DNA leading to aging. In the present study, a potential cosmetic nano-emulsion (o/w) of seven substances (chlorogenic acid, caffeine, rutin, hesperidin, quercetin, α-tocopherol retinol) with antioxidant anti-aging properties was prepared analyzed. The lipophilic components were entrapped in dispersed nanoparticles (jojoba) emulsion while hydrophilic ones dissolved aqueous phase...
The theoretical interpretation of the vaginal permeability phenomenon, evaluation suitability five artificial membranes, and prediction behaviors drugs were main objectives this study. Franz vertical diffusion cells different validated HPLC methods used to measure six vaginally administered (econazole, miconazole, metronidazole, clindamycin, lidocaine, nonoxynol-9). This study was performed (in vitro) on membranes polyvinylidene fluoride (PVDF), plain cellulose or impregnated with isopropyl...
Buccal films containing two vitamins, i.e., thiamine hydrochloride (THCl) and nicotinic acid (NA), were fabricated via two-dimensional (2D) inkjet printing. For the preparation of buccal films, solubility studies rheological evaluations conducted in distilled water propylene-glycol (PG) as main solvent viscosity/surface tension modifier, respectively. The increased solvents’ mixture indicated that manufacturing several doses THCl NA is achievable. Various deposited onto sugar-sheet...
A salting-out homogeneous liquid-liquid microextraction was proposed for the quantification of four azole drugs in human urine prior to high-performance liquid chromatography analysis. The procedure involved mixing sample with acetonitrile appropriate volumes followed by addition sodium sulfate solution order facilitate phase separation. parameters influencing extraction performance were studied and optimized using a two-step experimental design. analytical thoroughly validated accuracy...
Electrospray ionization (ESI) is predominant among soft techniques since it considered as the method of choice for coupling liquid chromatography with mass spectrometry (LC-MS). Despite progress which has been achieved in ion formation theory, research community keep their interest parameters affecting increase responsiveness signal. This particular problem becoming more complex when analytes studied are compounds not having characteristic moieties, responsible a molecule's (carboxylic or...
Abstract A high-performance liquid chromatography (HPLC) method for the simultaneous determination of bamipine, phenylephrine or (phenylpropanolamine, ephedrine) and dextromethorphan has been developed. The proved suitable analysis compounds in various pharmaceutical formulations. From sample solutions no interference was observed on chromatographs. accuracy assay assessed. Recovery studies have also carried out by adding known quantities active ingredients to placebo samples (spiking recoveries).