A5089918409- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Wound Healing and Treatments
- Additive Manufacturing and 3D Printing Technologies
- Botulinum Toxin and Related Neurological Disorders
- Microencapsulation and Drying Processes
- Electrospun Nanofibers in Biomedical Applications
- Proteins in Food Systems
- Bee Products Chemical Analysis
- Ocular Surface and Contact Lens
- Dermatology and Skin Diseases
- Pickering emulsions and particle stabilization
- Bone Tissue Engineering Materials
- Electrohydrodynamics and Fluid Dynamics
- Pancreatic function and diabetes
- biodegradable polymer synthesis and properties
- Cannabis and Cannabinoid Research
- Pharmaceutical studies and practices
- Food Chemistry and Fat Analysis
- Drug Solubulity and Delivery Systems
- Diabetic Foot Ulcer Assessment and Management
- Phytochemistry and biological activity of medicinal plants
- Biochemical Analysis and Sensing Techniques
Aristotle University of Thessaloniki
2018-2025
A pressure ulcer is the necrosis of skin and tissues due to prolonged pressure. Its prevention treatment are great importance not only for health but also patient’s quality life considered highest priority. In present study, a reliable analytical method developed quantitative determination panthenol, hesperidin, rutin, allantoin by HPLC UV detectors. The substances were formulated into pharmaceutical gel, with healing regenerative properties recommended first- second-degree bedsores. Their...
Microneedle (MN) patches are gaining increasing attention as a cost-effective technology for delivering drugs directly into the skin. In present study, two different 3D printing processes were utilized to produce coated MNs, namely, digital light processing (DLP) and semisolid extrusion (SSE). Donepezil (DN), cholinesterase inhibitor administered treatment of Alzheimer's disease, was incorporated coating material. Physiochemical characterization MNs confirmed successful incorporation...
In this study, drug carrier nanoparticles comprised of Pluronic-F127 and cannabidiol (CBD) or cannabigerol (CBG) were developed, their wound healing action was studied. They further incorporated in 3D printed films based on sodium alginate. The prepared characterized morphologically physicochemically used to evaluate the release profiles nanoparticles. Additional studies water loss rate, retention capacity, 3D-printing shape fidelity performed. Nanoparticles for loading performance. assessed...
In the present study, two different microneedle devices were produced using digital light processing (DLP). These hold promise as drug delivery systems to buccal tissue they increase permeability of actives with molecular weights between 600 and 4000 Da. The attached reservoirs designed printed along arrays a whole device. Light microscopy was used quality control printability designs, confirming that actual dimensions are in agreement design. Non-destructive volume imaging by means...
Dissolving microneedles (MNs) are promising transdermal drug delivery systems that can effectively increase the absorption of drugs. They bypass first layer skin, stratum corneum (SC) and deliver drugs directly into dermis, by dissolving inside interstitial fluid releasing active. The traditional ways MN fabrication involve primarily micromolding, which basically uses silicone molds. Drugs polymer mixture solutions poured these molds after drying arrays carefully removed. In present study, a...
In the current study a 3D-printable system was developed, based on natural, food-grade and nontoxic materials that may be used as platform technology to host cannabinoids, more specifically CBD for medicinal purposes. Pectin honey were combined toward fabrication of 3D printable inks form solid structures upon drying. This model 3D-printed evaluated matrix incorporation CBD, in inclusion complexes with β-cyclodextrins. The prepared characterized by means Differential Scanning Calorimetry...
In the current study, coated microneedle arrays were fabricated by means of digital light processing (DLP) printing. Three different shapes designed, printed, and with PLGA particles containing two actives. Rivastigmine (RIV) N-acetyl-cysteine (NAC) coformulated via electrohydrodynamic atomization (EHDA), they incorporated into particles. The actives are administered as a combined therapy for Alzheimer's disease. printed evaluated regarding their ability to penetrate skin mechanical...
Printing technologies have recently emerged in the development of novel drug delivery systems toward personalized medicine, to improve performance formulations, existing bioavailability patterns, and patients’ compliance. In context two-dimensional printing, this article presents buccal films that are designed efficiently deliver a class II compound (diclofenac sodium), according Biopharmaceutics Classification System (BCS), oral cavity. The preparation drug-loaded inks was carried out based...
Buccal films containing two vitamins, i.e., thiamine hydrochloride (THCl) and nicotinic acid (NA), were fabricated via two-dimensional (2D) inkjet printing. For the preparation of buccal films, solubility studies rheological evaluations conducted in distilled water propylene-glycol (PG) as main solvent viscosity/surface tension modifier, respectively. The increased solvents’ mixture indicated that manufacturing several doses THCl NA is achievable. Various deposited onto sugar-sheet...
Medium Chain Triglyceride (MCT) oil was successfully combined with Glyceryl Monostearate (GMS) and Monoolein (GMO) to form oleogels that were subsequently whipped stable oleofoams. The co-crystallization of GMS GMO at a ratio 20:1, 20:2.5, 20:5 within MCT studied through Differential Scanning Calorimetry (DSC), X-ray Diffraction analysis (XRD), rheological analysis, Fluorescence Recovery after Photobleaching (FRAP), Fourier Transform Infrared Spectroscopy (FTIR), polarized microscopy....
Tissue-engineered oral epithelium (ΤΕΟΕ) was developed after comparing various culture conditions, including submerged- and air-liquid interface (ALI) human cell expansion options. Barrier formation evaluated via transepithelial electrical resistance (TEER) calcein permeation spectrofluorometry. TEOE further assessed for long-term viability live/dead staining development of intercellular connections transmission electron microscopy (TEM). Tissue architecture histochemistry the expression...
In the present study, a customized device (Epi-ExPer) was designed and fabricated to facilitate an epithelial organ culture, allowing for controlled exposure exogenous chemical stimuli accommodating evaluation of permeation tissue after treatment. The Epi-ExPer system using stereolithography (SLA)-based additive manufacturing (AM) method. Human porcine oral mucosa tissues were inserted into exposed resinous monomers commonly released by dental restorative materials. effect these xenobiotics...
To cover the unpleasant taste of amoxicillin (250 mg), maize starch (baby food) and milk chocolate were co-formulated. The raw materials final formulations characterized by means Dynamic Light Scattering (DLS), Differential Scanning Calorimetry (DSC) Fourier-Transform Infrared (FT-IR) spectroscopy. evaluate masking two different groups volunteers used, according to Ethical Research Committee Aristotle University Thessaloniki. optimization excipients' content in tablet was determined...