Abstract This minireview focuses on recent advancements in the synthesis of planar chiral ferrocenes by means transition‐metal‐catalyzed enantioselective C−H activation. Enantioenriched are synthesized through simple straightforward asymmetric carbon−carbon or carbon−heteroatom bond‐formation reactions. In these reports, site selectivity ferrocene activation is controlled two strategies, coordination direction and intramolecular cyclization. Herein significance results summarized.

Abstract We describe herein an efficient organocatalytic system for the selective N ‐methylation and ‐formylation of amines with carbon dioxide (CO 2 ) as a sustainable C1 feedstock polymethylhydrosiloxane (PMHS) cost‐effectvie reducing reagent. High‐yielding products are obtained low catalyst loading (1%) DBU. Selective is achieved using same catalytic at lower reaction temperature. magnified image

Abstract We herein describe an efficient iron‐catalyzed selective N ‐methylation and ‐formylation of amines with CO 2 silane using mono‐phosphine as ligand. With commercially available [CpFe(CO) ] catalyst, Fe‐catalyzed methylation was achieved triphenylphosphine a Using tributylphosphine ligand, formylation realized at lower temperature. The method successfully applied in the late‐stage drug molecules containing amine moiety. magnified image

An efficient visible light-facilitated decarbon-carboxylation of activated alkenes has been successfully developed.Compared with traditional alkene carboxylation, this method features mild conditions, up to 96% yield and good compatibility a variety functional groups.It provides new for the synthesis phenylacetic acid its derivatives.The mechanism study shows that reaction realizes corresponding carboxylic constant apparent carbon number by substituting carbon-carbon double bond...

A Ni-mediated oxidative C(sp³)–H functionalization of <italic>N</italic>,<italic>N</italic>-substituted amides with α,α-diaryl allylic alcohols through a radical 1,2-aryl migration process has been developed. This features broad substrate scope and excellent functional group tolerance.

The asymmetric total synthesis of (-)-retigeranic acid A has been realized. key features the current include (1) a Pt-catalyzed Conia-ene 5-exo-dig cyclization enolyne to establish quaternary stereochemical center C-10 (D/E ring), (2) an intramolecular diastereoselective Prins construct trans-hydrindane backbone (A/B and (3) late-stage Fe-mediated hydrogen atom transfer (HAT) Baldwin-disfavored 5-endo-trig radical rapidly assemble vicinal centers core structure (C ring).

Although photothermal catalysis is a clean, efficient, and green approach to access organic products, its application in the synthesis transformation of covalent frameworks (COFs), however, still unprecedented. Herein, we report catalytic C‐C bond linked COF under visible light, which can be reusable photocatalyst highly promote oxidation benzyl amines. Furthermore, have developed new postsynthetic modification strategy construct COFs by photoinduced thermally‐driven hydroamination via...

Although photothermal catalysis is a clean, efficient, and green approach to access organic products, its application in the synthesis transformation of covalent frameworks (COFs), however, still unprecedented. Herein, we report catalytic C‐C bond linked COF under visible light, which can be reusable photocatalyst highly promote oxidation benzyl amines. Furthermore, have developed new postsynthetic modification strategy construct COFs by photoinduced thermally‐driven hydroamination via...

Chiral phospholane ligands and catalysts have been widely applied in asymmetric catalysis synthesis. However, the construction of chiral skeleton remains challenging primarily relies on use auxiliaries or resolution. In this work, a highly enantioselective diastereoselective synthesis P-stereogenic oxides has achieved through cobalt-catalyzed desymmetric hydroalkylation strategy. This method enables two discrete stereocenters with excellent yields enantiomeric excesses.

An efficient copper-catalyzed asymmetric ring-opening reaction of diaryliodonium salts with imides has been developed, affording a wide range axially chiral 2-imidobiaryl compounds excellent enantioselectivities and better convertibility. The potential utility the current method supported by synthesis two known ligands efficiency, which would be great significance to development other catalytic reactions.

A Strecker type reaction between aldehydes and readily available N,N-disubstituted aminomalononitriles has been realized for the first time to give an alternative strategy synthesis of α-aminonitriles. This features broad substrate scope use water as solvent, its utility supported by formal racemic Clopidogrel a 3-aminoindole compound.

A nickel-catalyzed arylation of both aliphatic and aromatic aldehydes proceeds with air-stable (hetero)arylboronic acids, an exceptionally wide substrate scope. The neutral condition tolerates acidic hydrogen sensitive polar groups also preserves α-stereocenters some chiral aldehydes. Interestingly, this nickel(0) catalysis does not follow common 1,2-insertion arylmetal species to β-hydrogen elimination.

A new transition-metal-free reductive deoxygenative olefination of phosphorus ylides with CO2, an abundant and sustainable C1 chemical feedstock, is described. This catalytic CO2 fixation afforded β-unsubstituted acrylates vinyl ketones in good yields broad scope functional group tolerance under mild reaction conditions. Cost-effective easily handled polymethylhydrosiloxane was used as a reductant. Bis(silyl)acetal proved to be the key intermediate this functionalization CO2.

Main observation and conclusion Herein, we describe a novel catalytic Pictet‐Spengler‐type cyclization using CO 2 as nontoxic sustainable C1 feedstock with environmentally benign non‐precious‐metal iron catalyst. The reaction is achieved by selective four‐electron reduction of into methylene level intermediate through carefully tuning the parameters. A variety tetrahydro‐β‐carbolines other nitrogen‐containing heterocycles can be easily obtained under mild conditions. Mechanistic studies have...

A novel carbon electrophile induced intermolecular oxa-Diels-Alder/semipinacol rearrangement/aldol cascade reaction of allylic silyl ether with β,γ-unsaturated α-ketoester has been developed under the promotion SnCl4. This highly efficient transformation enables quick construction polycyclic architectures up to five contiguous stereogenic centers in a single operation moderate good yields as well high diastereoselectivity and would provide versatile short approaches frameworks and/or...

Abstract A simple and efficient strategy for the construction of 6‐ aza/oxa ‐spiro[4.5]decane skeletons under cocatalysis gold(I)/copper(II) was developed, its potential utility demonstrated by a formal synthesis biologically active marine alkaloid (±)‐halichlorine. magnified image

Abstract A novel and efficient strategy to build α‐benzylic quaternary cyclopentanones with excellent enantioselectivities (up 96 % ee ) high yields 99 yield) has been developed, its application demonstrated by the first catalytic asymmetric total synthesis of (−)‐1,14‐herbertenediol formal (−)‐aphanorphine.

An Au(I)-catalyzed tandem reaction for the synthesis of 2-phenyl-1,4,5,6-tetrahydrocyclopenta[b]pyrrole derivatives from 1-(1-hydroxy-3-phenylprop-2-yn-1-yl)cyclobutanol and primary amines or NH4OAc has been developed to afford a series polysubstituted pyrroles in moderate good yields.

A polyene cyclization mode using the allene group as initiator has been successfully developed, and its potential utility well demonstrated by collective synthesis of seven abietane-type diterpenoids.

A catalytic asymmetric 1,3-acyloxy shift/polyene cyclization cascade has been achieved with good enantioselectivities under the catalysis of chiral Au(I) reagent. The synthetic utility this method showcased by total syntheses (+)-2-ketoferruginol, (+)-fleuryinol B, and (+)-salviol. Notably, first enantioselective synthesis (-)-erythroxylisin also realized in 15 steps.

This work discloses an iridium-catalyzed selective arylation of B(6)–H 3-Ar- o -carboranes with arylboronic acid via direct B–H activation for the first time.

An organocatalytic enantioselective alkylation of α,α-disubstituted aldehydes with 3-bromooxindoles is reported. Enantioenriched oxindoles vicinal quaternary stereocenters are accessed by an asymmetric conjugate addition process branched o-azaxylylene intermediates (indol-2-ones). Key to the success highly diastereo- and transformations combined use a triphenylsilyl-protected β-amino alcohol catalyst derived from spiropyrrolidine scaffold 3,5-dinitrobenzoic acid. This study also presents...