A5106741780- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiation Dose and Imaging
- Cancer, Hypoxia, and Metabolism
- Advanced X-ray and CT Imaging
- Peptidase Inhibition and Analysis
- Lung Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Advanced Sensor and Energy Harvesting Materials
- Cardiac Imaging and Diagnostics
- Pituitary Gland Disorders and Treatments
- Conducting polymers and applications
- Adrenal and Paraganglionic Tumors
- Orthopedic Infections and Treatments
- Ubiquitin and proteasome pathways
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Rheumatoid Arthritis Research and Therapies
- Adrenal Hormones and Disorders
- Head and Neck Surgical Oncology
- HER2/EGFR in Cancer Research
- Immune cells in cancer
- Foot and Ankle Surgery
- Thyroid and Parathyroid Surgery
Post Graduate Institute of Medical Education and Research
2013-2025
Creative Commons
2023
Govind Ballabh Pant University of Agriculture and Technology
2022
Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital
2015
Abstract Background Corticotrophin-releasing hormone (CRH) is the major regulator of adrenocorticotrophic (ACTH) secretion from anterior pituitary and acts via CRH-1 receptors (CRH-1R). Corticotropinoma though autonomous, still retain their responsiveness to CRH hence, we hypothesize that in vivo detection on adenoma using Gallium-68 (68Ga)-tagged can indicate functionality adenoma, combining it with positron emission tomography-computed tomography (PET-CT) provide requisite anatomical...
The role of 2-deoxy-2-18(F) fluoro-D-glucose (FDG) positron emission tomography (PET)-computed (CT) in assessing treatment response chronic pulmonary aspergillosis (CPA) remains to be determined. study objective was compare FDG-PET/CT parameters persons with CPA achieving success or failure after 6 months oral itraconazole. We performed PET-CT at baseline and itraconazole therapy. FDG uptake similar the background ≥13 units decline Z-score considered a complete metabolic (CMR). A >25%, >30%,...
Metastatic or recurrent adrenocortical carcinoma (ACC) is a potentially fatal malignancy, which poses major challenges in disease management owing to lack of effective systemic therapies. The drastically reduced survival rates require prompt identification selective molecules for development targeted therapeutics. We evaluated the squaric acid containing FAPI derivative, DOTA.SA.FAPI (FAPI), as potential diagnostic probe 2 cases histopathologically proven metastatic and ACC. Both patients...
Purpose of the Report Tuberculosis (TB) is a major health problem. Activated macrophages in TB lesions show high metabolic activity and can be assessed using 18 F-FDG PET/CT. This retroprospective study was done to evaluate utility PET/CT initial assessment therapeutic response patients with TB. Materials Methods Eighty-seven (male-to-female ratio, 46:41) diagnosed pulmonary extrapulmonary underwent whole-body for follow-up scan 3 4 months after initiation antitubercular therapy (ATT)....
This study was undertaken to evaluate the effect of external metal filters on image quality computed tomography (CT) and single photon emission (SPECT)/CT images. Images Jaszack phantom filled with water containing iodine contrast syringes were acquired using CT (120 kV, 2.5 mA) component SPECT/CT system, ensuring fixation filter X-ray collimator. Different thickness Al Cu (1 mm, 2 3 4 mm) combinations 1 mm each in combination mm), respectively, used. All sets visually analyzed for streak...
The expression of alpha-five beta-three (αVβ3) integrins is upregulated in various malignancies undergoing angiogenesis. development integrin antagonists as diagnostic probes makes the αVβ3 a suitable candidate for targeting tumor goal this study was to optimize radiolabeling and evaluate potential conjugated antagonist carbamate (IAC), peptidomimetic, theranostic radiopharmaceutical
The aim of the study was to estimate radiation burden personnel performing robotic arm-assisted positron emission tomography/computed tomography (PET/CT)-guided metabolic biopsies and staff assisting procedure in a PET/CT facility.We estimated whole-body exposures physicians based on dose rate measurement with an ionization chamber-based calibrated survey monitor pocket dosimeters during 2-[F-18]-fluoro-2-deoxy-D-glucose PET/CT-guided from September 2016 February 2017. In addition, we also...
The present study aimed to optimize the injected dose of <sup>18</sup>F-FDG in whole-body PET/CT scans and assess its effect on noise-equivalent count rate (NECR) visual image quality (IQ). <b>Methods:</b> Patients scheduled undergo were prospectively recruited from January December 2019, regardless indication or underlying disease. divided into 4 groups with different amounts radioactivity per kilogram body weight (1.85, 3.7, 5.5, 7.4 MBq/kg). All patients underwent studies,...
Abstract Breast cancer is the most common in women with rising incidence worldwide. 18 F-FDG PET/CT imaging has already established itself as a pivotal modality for staging, restating and response assessment patients carcinoma breast. The complex biology of this increasingly being decoded various molecular targets have been identified exploited guiding treatment at time points during course disease. We here depict series metabolic receptor targeting PET radiotracers breast which may help us...
Radioiodine (I-131) is used as an effective noninvasive treatment for thyroid malignancies. Salivary gland one of the most affected nontarget organs. The present study aims to perform early quantification salivary function after I-131 therapy (RIT) cancer considering down-scatter in Tc-99m window.A total 20 patients (6 males and 14 females) with differentiated carcinoma were enrolled study. Baseline dynamic scintigraphy was performed all using 185-370 MBq (5-10 mCi) pertechnetate....
Objective The aim of this study was to compare the performance angiogenesis-specific 68 Ga-RGD 2 PET/CT with Disease Activity Score 28–erythrocyte sedimentation rate (DAS28-ESR) in assessing disease activity and treatment response rheumatoid arthritis (RA). Methods This a prospective comparing DAS28-ESR 30 RA patients. All them underwent scan from head toe clinical examination at baseline. A repeat were done 27 patients after 3 months disease-modifying antirheumatic drugs ± steroids. Three...
Abstract 18 F-FDG PET/CT imaging is an important diagnostic tool for accurate staging and assessment of response to neoadjuvant chemotherapy (NACT) in patients with locally advanced breast carcinoma (LABC). However, being non-specific marker, it also accumulates inflammatory conditions, leading false positive results. Angiogenesis, essential characteristic tumor development, intrusion metastasis can be imaged using 68 Ga-labeled RGD tripeptide. We here depict a series clinically staged LABC...
Purpose: Adrenocorticotropic hormone (ACTH)-dependent Cushing's disease accounts for 75% cases of the endogenous syndrome. The size lesion is usually very small, which results in false-negative magnetic resonance imaging (MRI) even after biochemical confirmation disease. Corticotrophin-releasing (CRH) key controller hypothalamus-pituitary--adrenal axis binds to CRH receptor R1 and R2. overexpressed pituitary adenomas. present study aims target these receptors with 68Ga-DOTA-CRH noninvasive...
We aimed to evaluate the radiation exposure patients undergoing positron emission tomography/computed tomography (PET/CT)-guided biopsies.Patients PET/CT-guided biopsy were recruited prospectively from October 2019 April 2020. a tracer avid site was done using an automated-robotic-arm 1 h after intravenous injection of F-18-fluorodeoxyglucose (FDG) (2-5 mCi) or Ga-68-PSMA (1-4 mCi). Regional CT-images acquired for planning and confirmation needle placement. The internal due PET component...
Abstract Duramycin, a 19 amino acids peptide, is known for its potential to target phosphatidylethanolamine. During cell death (apoptosis), rearrangement of membrane phospholipids results in the externalization phosphatidylethanolamine outer leaflet membrane, which can be imaged using 68 Ga-NOTA-duramycin. We report Ga-NOTA-duramycin imaging 50-year-old man with biopsy-proven diffuse large B-cell lymphoma planned anthracycline-based chemotherapy. PET/CT along 18 F-FDG was performed before...
Abstract Prostate cancer (PCa) is one of the major causes death due to in men. Conventional imaging modalities such as magnetic resonance (MRI) provide locoregional status, but fall short identifying distant metastasis. C-11 choline F-18 fluorocholine (F-18 FCH) has been shown be useful PCa. The present prospective study evaluates and compares role FCH positron emission tomography–computed tomography (PET-CT) with MRI whole-body bone scintigraphy PCa patients for initial staging recurrence...