A5101746514- Metal-Organic Frameworks: Synthesis and Applications
- Supramolecular Chemistry and Complexes
- Advanced Database Systems and Queries
- Cloud Computing and Resource Management
- Immunotherapy and Immune Responses
- Advanced Data Storage Technologies
- Organometallic Complex Synthesis and Catalysis
- Circular RNAs in diseases
- Molecular Biology Techniques and Applications
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Cancer Immunotherapy and Biomarkers
- Advanced Vision and Imaging
- Hippo pathway signaling and YAP/TAZ
- Sirtuins and Resveratrol in Medicine
- Advanced Image and Video Retrieval Techniques
- Angiogenesis and VEGF in Cancer
- Plant Pathogens and Fungal Diseases
- Fungal Biology and Applications
- Eosinophilic Esophagitis
- Bioactive natural compounds
- Service-Oriented Architecture and Web Services
- IL-33, ST2, and ILC Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Graph Theory and Algorithms
- Proteoglycans and glycosaminoglycans research
Zhongshan Hospital
2022-2024
Fudan University
2022-2024
University of Chinese Academy of Sciences
2011-2022
Chinese Academy of Sciences
2009-2022
Shanghai Institutes for Biological Sciences
2010-2022
Ministry of Education of the People's Republic of China
2021-2022
Northwest University
2021-2022
South China Institute of Collaborative Innovation
2022
Shanghai Institute of Nutrition and Health
2022
ShanghaiTech University
2022
Abstract Background Inflammatory responses in the CNS mediated by activated glial cells play an important role host-defense but are also involved development of neurodegenerative diseases. Resveratrol is a natural polyphenolic compound that has cardioprotective, anticancer and anti-inflammatory properties. We investigated capacity resveratrol to protect microglia astrocyte from inflammatory insults explored mechanisms underlying different inhibitory effects on astrocytes. Methods A murine...
Neoantigen-directed therapy lacks preclinical models recapitulating neoantigen characteristics of original tumors. It is urgent to develop a platform assess T cell response for screening. Here, immunogenic potential neoantigen-peptides tumor tissues and matched organoids (n = 27 pairs) are analyzed by Score tools with whole genome sequencing (WGS)-based human leukocyte antigen (HLA)-class-I algorithms. The comparisons between 9203 predicted from 2449 mutations 9991 ones 2637 demonstrate that...
HAWQ, developed at Pivotal, is a massively parallel processing SQL engine sitting on top of HDFS. As hybrid MPP database and Hadoop, it inherits the merits from both parties. It adopts layered architecture relies distributed file system for data replication fault tolerance. In addition, standard compliant, unlike other engines fully transactional. This paper presents novel design including query processing, scalable software interconnect based UDP protocol, transaction management, tolerance,...
Tangled cubes feature the topology of typical Platonic cubes, with their "faces" traversed by edges in different ways. This study generates an "A-type" tangled metallocube from reaction binuclear gold-NHC complex and H2 S. The cube was validated multinuclear nuclear magnetic resonance (NMR) spectroscopy, high-resolution electrospray-ionization (HR-ESI) mass spectrometry, single-crystal X-ray diffraction analysis. offers a simple effective approach to designing fabricating new, topologically...
Colorectal cancer (CRC) is a highly prevalent malignancy affecting the digestive system on global scale. This study aimed to explore previously unexplored role of CHPF in progression CRC. Our results revealed significant upregulation expression CRC tumour tissues compared normal tissues, with its levels correlating malignancy. In vitro experiments using cell lines demonstrated that inhibiting suppressed proliferation, colony formation and migration, while promoting apoptosis. Conversely,...
The application of tumor antigen-based immunotherapy is hindered by the rarity validated immunogenic peptides. In this study, we aimed to investigate potential circular RNAs (circRNAs) as a novel source antigen peptides in hepatobiliary organoids. Using RNA-sequencing (RNA-seq) with an algorithm-based score tool, 3950 translated tumor-specific circRNAs were predicted generate 18 971 27 view landscape, 11 amino acid length (mer) and human leukocyte (HLA)-A binding harbored highest...
Immune-mediated neuroinflammation has been proposed to underlie the loss of lower esophageal sphincter (LES) myenteric neurons in achalasia. However, immune status and key pathogenic subpopulations remain unclear. This study aims evaluate inflammatory patients with achalasia their correlation clinical characteristics, further explore subpopulations.We investigated complete blood cell count markers a large population (n = 341) healthy controls 80). The lymphocytes were analyzed by flow...
With MapReducepsilas restricted structure, multi-datasets merging problem, commonly in many data mining applications, cannot be efficiently resolved with MapReduce. This paper proposes a novel hybrid datasets algorithm on top of Map Reduce, HDMA. HDMA can help to automatically determine the relatively better one between two methods, DMCM and DPM, which have different effective fields. retains advantages both it make good use memory nodes. Experiments show that get best performance most situations.
Abstract Tangled cubes feature the topology of typical Platonic cubes, with their “faces” traversed by edges in different ways. This study generates an “ A ‐type” tangled metallocube from reaction binuclear gold‐NHC complex and H 2 S. The cube was validated multinuclear nuclear magnetic resonance (NMR) spectroscopy, high‐resolution electrospray‐ionization (HR‐ESI) mass spectrometry, single‐crystal X‐ray diffraction analysis. offers a simple effective approach to designing fabricating new,...
Hadoop has shown great power in processing vast data parallel. Hive, the database on Hadoop, enables more experts to process relational by providing sql-like interface. However, Hive does not provide an efficient approach for join, a common but expensive operator database. Due importance of this paper proposes novel hybrid algorithm, HJA, which can help automatically choose relatively better one among several methods, divide and memory copy merge, Partition Join(PJ) naïve join. Experiments...
We propose a pyramid based representation together with partial weighted similarity measure to address the occlusion problem in visual tracking. In current histogram tracking methods, due lost of spatial information, cannot be handled very well. this paper, is introduced into Bayesian inference framework, which approximate global information retained and multi-scale explored. Correspondingly, considering that visible parts occluded target high resolution should have more contribution...
The post‐assembly modification (PAM) of metallosupramolecular assemblies plays an important role in obtaining diverse architectures and expanding new functions. In this work, the trinuclear organometallic [Ag 3 ( L ) 2 ](PF 6 = 1a – c were generated from corresponding internal olefin‐bridged trisimidazolium, trisbenzoimidazolium, trisimidazo[1,5‐ ɑ ]pyridinium salts H ‐ (PF with Ag O through coordination‐driven self‐assembly. Subsequently, complexes , 1b converted into gold(I) [Au I by...