A5019791805- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Shape Memory Alloy Transformations
- Advanced Neuroimaging Techniques and Applications
- Cerebral Palsy and Movement Disorders
- Functional Brain Connectivity Studies
- Magnetic and transport properties of perovskites and related materials
- Neurogenetic and Muscular Disorders Research
- Heusler alloys: electronic and magnetic properties
- Magnetic Properties and Applications
- MRI in cancer diagnosis
- Spinal Dysraphism and Malformations
- Cerebral Venous Sinus Thrombosis
- Diet and metabolism studies
- Vestibular and auditory disorders
- Dementia and Cognitive Impairment Research
- Neurological disorders and treatments
- Visual Attention and Saliency Detection
- Intracerebral and Subarachnoid Hemorrhage Research
- Machine Learning in Materials Science
- Cholinesterase and Neurodegenerative Diseases
- Subtitles and Audiovisual Media
- Magnetic Properties of Alloys
- Explainable Artificial Intelligence (XAI)
- Multiferroics and related materials
University of Newcastle Australia
2024-2025
Hunter Medical Research Institute
2024
Universität Ulm
2021-2023
University Hospital Ulm
2023
Hologic (Germany)
2023
Leibniz Institute for Solid State and Materials Research
2013-2015
Bielefeld University
2015
Abstract Scientific discoveries often hinge on synthesizing decades of research, a task that potentially outstrips human information processing capacities. Large language models (LLMs) offer solution. LLMs trained the vast scientific literature could integrate noisy yet interrelated findings to forecast novel results better than experts. Here, evaluate this possibility, we created BrainBench, forward-looking benchmark for predicting neuroscience results. We find surpass experts in...
Background: Over the life span, diffusion metrics in brain MRI show different, partly nonlinear changes. These age-dependent changes also seem to exhibit regional differences with respect anatomy. The age correction of a study cohort's might thus require consideration age-related factors. Methods: Diffusion tensor imaging data sets were acquired from 219 healthy participants at ages between 19 and 81 years. Fractional anisotropy (FA), mean diffusivity (MD), axial radial (AD RD, respectively)...
The complex nature of magnetic ordering in the spinel $\mathrm{C}{\mathrm{o}}_{2}\mathrm{Ti}{\mathrm{O}}_{4}$ is investigated by analyzing temperature and field dependence its magnetization ($M$), specific heat (${C}_{\mathrm{p}}$), ac susceptibilities ${\ensuremath{\chi}}^{\ensuremath{'}}$ ${\ensuremath{\chi}}^{\ensuremath{''}}$. X-ray diffraction sample synthesized solid-state reaction route confirmed structure whereas x-ray photoelectron spectroscopy shows electronic to be...
Temperature affects the kinetics of all biochemical processes. Consequently, brain temperature is a key factor in neuronal excitability and synaptic function, with significant implications for both physiological pathological activity. Recent studies have refined our understanding principles underlying thermoregulation enhanced thermometric techniques could open new avenues therapeutic strategies.In this review, we highlight biological basis thermal homeostasis brain: Heat generated by...
The structural, magnetic, and magnetocaloric properties of epitaxial Ni-Co-Mn-Al thin films with different compositions have been studied. were deposited on MgO(001) substrates by co-sputtering heated substrates. All show a martensitic transformation, where the transformation temperatures are strongly dependent composition. structure martensite phase is shown to be 14M. metamagnetic occurs from ferromagnetic austenite weakly magnetic martensite. structural investigated atomic force...
Within the core neuroimaging signature of amyotrophic lateral sclerosis (ALS), corpus callosum (CC) is increasingly recognized as a consistent feature. The aim this study was to investigate sensitivity and specificity microstructural segmental CC morphology, assessed by diffusion tensor imaging (DTI) high-resolution T1-weighted (T1w) imaging, in large cohort ALS patients including different clinical phenotypes. In single-centre study, 575 with (classical phenotype, N = 432; restricted...
Diffusion tensor imaging (DTI) can be used to tract-wise map correlates of the sequential disease progression and, therefore, assess stages amyotrophic lateral sclerosis (ALS) in vivo. According a threshold-based scheme, classification ALS patients into is possible, however, several cannot staged for methodological reasons. This study aims implement multivariate Bayesian algorithm stage prediction at an individual patient level based on DTI metrics involved tract systems improve mapping.The...
Cognition and behaviour are emergent properties of brain systems that seek to maximise complex adaptive while minimising energy utilization. Different species reconcile this trade-off in different ways but humans the outcome is biased towards behaviours hence relatively high use. However, even intensive brains, numerous parsimonious processes operate optimize We review how balance manifests both homeostatic task-associated cognition. also consider perturbations disruptions metabolism...
The potential of multiparametric quantitative neuroimaging has been extensively discussed as a diagnostic tool in amyotrophic lateral sclerosis (ALS). In the past, integration multimodal, data into useful classifier was major challenge. With recent advances field, machine learning driven approach is solution: biomarkers ALS are mainly observed cerebral microstructure, with diffusion tensor imaging (DTI) and texture analysis promising approaches. We set out to combine these markers...
A thickness dependent exchange bias in the low temperature martensitic state of epitaxial Ni-Mn-Sn thin films is found. The effect can be retained down to very small thicknesses. For a Ni50Mn32Sn18 film, which does not undergo transformation, no observed. Our results suggest that significant interplay between ferromagnetic and antiferromagnetic regions, origin for bias, only present martensite. finding supported by ab initio calculations showing order stabilized phase.
The exchange bias effect is commonly used to shift the coercive field of a ferromagnet. This technique crucial for use magnetic tunnel junctions as logic or memory devices. Therefore, an independent switching two ferromagnetic electrodes necessary guarantee reliable readout. Here, we demonstrate that intrinsic Ni-Mn-Sn can be apply unidirectional anisotropy junctions. For this, epitaxial films pinning layers microfabricated CoFeB/MgO/CoFeB We compare ($H_{\text{EB}}$) measured after cooling...
C9orf72 hexanucleotide repeat expansions are associated with widespread cerebral alterations, including white matter alterations. However, there is lack of information on changes in commissure fibres. Diffusion tensor imaging (DTI) can identify amyotrophic lateral sclerosis (ALS)-associated patterns regional brain alterations at the group level. The objective this study was to investigate structural connectivity corpus callosum (CC) ALS patients expansions.DTI-based mapping performed by a...
During the attempt to steadily fixate at a single spot, sequences of small involuntary fixation saccades (SIFSs, known also as microsaccades οr intrusions) occur which form spatio-temporal patterns such square wave jerks (SWJs), pattern characterised by alternating centrifugal and centripetal movements similar magnitude. In many neurodegenerative disorders, SIFSs exhibit elevated amplitudes frequencies. Elevated SIFS have been shown favour occurrence SWJs ("SWJ coupling"). We analysed in...
The clinical manifestation of amyotrophic lateral sclerosis (ALS) is characterized by motor neuron degeneration, whereas frontotemporal dementia (FTD) patients show alterations behavior and cognition. Both share repeat expansions in C9orf72 as the most prevalent genetic cause. Before disease-defining symptoms onset, structural functional changes at cortical level may emerge carriers. Here, we oculomotor parameters their association to neuropsychological domains apparently asymptomatic...
Abstract Background The underlying neuropathological process of amyotrophic lateral sclerosis (ALS) can be classified in a four‐stage sequential pTDP‐43 cerebral propagation scheme. Using diffusion tensor imaging (DTI), vivo these stages has already been shown to feasible for the specific corticoefferent tract systems. Because both cognitive and oculomotor dysfunctions are associated with microstructural changes at brain level ALS, an staging classification were developed, respectively....
The pathophysiology of idiopathic intracranial hypertension (IIH), a condition characterized by raised pressure, is not well understood.We hypothesized that the hypothalamus might exhibit alterations in patients with IIH, based on its established association obesity and potential role hormonal metabolic factors IIH.Retrospective single-center cohort study.Thirty-three individuals IIH 40 matched healthy were studied, including levels hormones proteins leptin, adiponectin, ghrelin, insulin,...
The neuropathology of amyotrophic lateral sclerosis (ALS) follows a regional distribution pattern in the brain with four stages. Using diffusion tensor imaging (DTI), this can be translated into tract-based staging scheme to assess cerebral progression vivo. This study investigates association between sequential alteration and disease severity patients ALS.DTI data 325 ALS 130 healthy controls were analyzed tract interest (TOI)-based approach. Patients categorized according their ALS-FRS-R...
Evidence suggests that poor sleep impacts cognition, brain health, and dementia risk but the nature of association is poorly understood. This study examined how self-reported duration, napping, subjective depression symptoms are associated with brain-cognition relationship in older adults, using sulcal width as a measure relative health.
Deficits in memory are seen as a canonical sign of aging and prodrome to dementia older adults. However, our understanding age-related cognition brain morphology occurring throughout broader spectrum adulthood remains limited. We quantified the relationship between cognitive function (sulcal width, SW) using three cross-sectional observational datasets (PISA, AIBL, ADNI) from mid-life adulthood, assessing influence age, sex, amyloid (Aβ) genetic risk for dementia. The data comprised...
Abstract Background The eponymous feature of progressive supranuclear palsy (PSP) is oculomotor impairment which one the relevant domains in Movement Disorder Society diagnostic criteria. Objective We aimed to investigate value specific video-oculographic parameters for use as markers PSP. Methods An analysis video-oculography recordings 100 PSP patients and 49 age-matched healthy control subjects was performed. Gain smooth pursuit eye movement latency, gain, peak velocity, asymmetry...
Combining conventional and inverse magnetocaloric materials promises to enhance solid state refrigeration. As a first step here we present epitaxial Ni–Mn–Ga/Ni–Mn–Sn bilayer films. We examine the dependence of lateral normal lattice constants on deposition sequence by combining experimental ab initio techniques. Structural properties are determined with X‐ray diffraction as well highresolution transmission electron microscopy, while calculations explain interplay strain, local relaxations...
Diffusion tensor imaging (DTI) can be used to map disease progression in amyotrophic lateral sclerosis (ALS) and therefore is a promising candidate for biomarker ALS. To this end, longitudinal study protocols need optimized validated regarding group sizes time intervals between visits. The objective of was assess the influences sample size, schedule follow-up measurements, measurement uncertainties on statistical power optimize DTI ALS.To estimate uncertainty tract-of-interest-based...