A5029174825- Stress Responses and Cortisol
- Trigeminal Neuralgia and Treatments
- Tryptophan and brain disorders
- Moyamoya disease diagnosis and treatment
- Migraine and Headache Studies
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Sirtuins and Resveratrol in Medicine
- Advanced MRI Techniques and Applications
- Biochemical effects in animals
- Hormonal Regulation and Hypertension
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Neurological Complications and Syndromes
- Lanthanide and Transition Metal Complexes
- Neurosurgical Procedures and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Explainable Artificial Intelligence (XAI)
- Glioma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Anesthesia and Neurotoxicity Research
- Neural dynamics and brain function
- Intracranial Aneurysms: Treatment and Complications
- Cognitive Science and Mapping
- Socioeconomic and Demographic Analysis
Novosibirsk State Technical University
2023-2025
Novosibirsk State Medical University
2023-2025
Federal Neurosurgical Center Novosibirsk
2022-2024
Universidad de Morelia
2024
South Ural State University
2018-2023
Vitebsk State Medical University
1997
Abstract Scientific discoveries often hinge on synthesizing decades of research, a task that potentially outstrips human information processing capacities. Large language models (LLMs) offer solution. LLMs trained the vast scientific literature could integrate noisy yet interrelated findings to forecast novel results better than experts. Here, evaluate this possibility, we created BrainBench, forward-looking benchmark for predicting neuroscience results. We find surpass experts in...
ABSTRACT Background and Purpose Primary trigeminal neuralgia (PTN) is a prevalent chronic pain disorder whose pathogenesis not solely confined to the system. Although substantial progress has been made in understanding underlying mechanisms, comprehensive consistent data concerning involvement of hippocampal formation this process are lacking. The aim study was evaluate structural changes subfields patients with PTN. Methods Fifty‐nine individuals who were diagnosed PTN 28 healthy controls...
Primary trigeminal neuralgia (PTN) is a prevalent chronic pain disorder. This condition believed to be associated with demyelination of the nerve. Previous studies in this field have focused on diffusion tensor imaging, which has limited sensitivity and specificity myelin. In present study, we assessed nerve root via macromolecular proton fraction (MPF) mapping technique. MPF demonstrated strong correlations myelin histology number earlier animal currently viewed as promising clinical...
Mesial temporal lobe epilepsy is the most common type of focal epilepsy, imposing a significant burden on health care system worldwide. Approximately one-third patients with this disease who do not adequately respond to pharmacotherapy are considered drug-resistant subjects. Despite having some clues how such epileptic activity and resistance therapy emerge, coming mainly from preclinical models, we still witness scarcity human data. To narrow gap, in study, aimed estimate relationship...
PTSD is associated with disturbed hepatic morphology and metabolism. Neuronal mitochondrial dysfunction considered a subcellular determinant of PTSD, but link between damage in has not been demonstrated. Thus, the effects experimental on livers high anxiety (HA) low (LA) rats were compared, determinants underlying difference their investigated. Rats exposed to predator stress for 10 days. Then, 14 days post-stress, evaluated an elevated plus maze assigned HA LA groups according index....
Stress-related anxiety disorders and anxiety-like behavior in post-traumatic stress disorder (PTSD) are associated with altered neurocircuitry pathways, neurotransmitter systems, the activities of monoamine glucocorticoid-metabolizing enzymes. Resveratrol, a natural polyphenol, is recognized for its antioxidant, anti-inflammatory, antipsychiatric properties. Previous studies suggest that resveratrol reduces animal PTSD models by downregulating key enzymes such as 11β-hydroxysteroid...
Background: Rats exposed to chronic predator scent stress mimic the phenotype of complex post-traumatic disorder (PTSD) in humans, including altered adrenal morphology and function. High- low-anxiety phenotypes have been described rats (PSS). This study aimed determine whether these high- correlate with changes histomorphology corticosteroid production. Methods: were PSS for ten days. Thirty days later, rats’ anxiety index (AI) was assessed an elevated plus-maze test. Based on differences...
Susceptibility and resilience to post-traumatic stress disorder (PTSD) are recognized, but their mechanisms not understood. Here, the hexobarbital sleep test (HST) was used elucidate of PTSD or susceptibility. A HST performed in rats 30 days prior further experimentation. Based on HST, were divided into groups: (1) fast metabolizers (FM; duration < 15 min); (2) slow (SM; ≥ min). Then SM FM groups subdivided stressed (10 predator scent, rest) unstressed subgroups. Among animals, only SMs...
We investigated the presence of a molecular pathway from hepatic 11-βHSD-1 to brain MAO-A in dynamics plasma corticosterone involvement anxiety development. During 14 days following repeated exposure rats predator scent stress for 10 days, variables were measured: and activities, norepinephrine, concentrations, anxiety, as reflected by performance on an elevated plus maze. Anxiety briefly decreased then increased after exposure. This behavioral response correlated inversely with activity. A...
Currently, the efficacy of drug therapy for post-traumatic stress disorder or PTSD leaves much to be desired, making nutraceutical support a promising avenue treatment. Recent research has identified protective effects resveratrol in PTSD. Here, we tested behavioral and neurobiological combining cheese consumption with supplements an experimental model. Using elevated plus maze test, observed that intake resulted shift from anxiety-like behavior depressive behavior, evident increased...
Scientific discoveries often hinge on synthesizing decades of research, a task that potentially outstrips human information processing capacities. Large language models (LLMs) offer solution. LLMs trained the vast scientific literature could integrate noisy yet interrelated findings to forecast novel results better than experts. To evaluate this possibility, we created BrainBench, forward-looking benchmark for predicting neuroscience results. We find surpass experts in experimental outcomes....
Diffuse gliomas present a significant challenge for healthcare systems globally. While brain MRI plays vital role in diagnosis, prognosis, and treatment monitoring, accurately characterizing using conventional techniques alone is challenging. In this study, we explored the potential of utilizing amide proton transfer (APT) technique to predict tumor grade type based on WHO 2021 Classification CNS Tumors.
In post-traumatic stress disorder (PTSD), anxiety-like symptoms are often associated with elevated noradrenaline levels and decreased serotonin. Selective serotonin reuptake inhibitors (SSRIs) frequently used to treat anxiety, but has been observed in some anxiety disorders. This study investigates stress-induced as an immediate effect of chronic exposure using the predator paradigm.
A paradoxical reduction in anxiety levels chronic predator stress paradigm (PS) Sprague-Dawley rats has recently been shown previous works. In this paper, we studied the possible neurobiological mechanism of phenomenon. We segregated PS-exposed into high- and low-anxiety phenotypes. The long-lasting effects PS on corticosterone levels, blood flow speed carotid arteries, diffusion coefficient, 1H nuclear magnetic resonance spectra hippocampus were compared high-anxiety rats. addition,...
Stress-induced conditions are associated with impaired cerebral blood flow (CBF) and increased risk of dementia stroke. However, these do not develop in resilient humans animals. Here the effects predator stress (PS, cat urine scent, ten days) on CBF mechanisms regulation were compared PS-susceptible (PSs) PS-resilient (PSr) rats. Fourteen days post-stress, rats segregated into PSs PSr groups based a behavior-related anxiety index (AI). its endothelium-dependent changes measured parietal...
The results of research on the problem stress and its consequences, primarily posttraumatic disorder, from position modern neuroscience are presented. Some relationships between neurobiology cognitive psychology described. review several actual problems computational neurobiology, artificial neural networks, neurocomputing supercomputing was performed. Particular attention is paid to characteristics possibilities using structural functional methods neuroimaging – various variants computer,...
Abstract Motivation As genomics data analysis becomes increasingly intricate, researchers face the challenge of mastering various software tools. The rise Pangenomics analysis, which examines complete set genes in a group genomes, is particularly transformative understanding genetic diversity. Our interdisciplinary team biologists and mathematicians developed short Workshop covering Bash, Python scripting, Pangenome, Topological Data Analysis. These skills provide deeper insights into...
Abstract Patients suffering from chronic pain are known to exhibit distinctive personality traits and impaired neuropsychological performance across various cognitive domains. However, there is currently a lack of comprehensive evidence regarding behavioral functioning patterns in patients with trigeminal neuralgia. In this study, we aimed thoroughly characterize range psychological variables sample 80 34 healthy controls, assess their relationship intensity duration. Our findings revealed...
Abstract Intelligence is increasingly recognized as a critical factor in successful behavioral and emotional regulation. Neuroimaging techniques coupled with machine learning algorithms have proven to be valuable tools for uncovering the neural foundations of individual cognitive abilities. Nevertheless, current electroencephalograph (EEG) studies primarily focus on classification tasks predict intelligence category subjects (e.g., high, medium, or low intelligence), rather than providing...
Abstract The use of machine learning techniques combined with advanced neuroimaging methods to reveal a complex relationship between patterns neuronal activity and behavioral characteristics is an actively developing area in modern neuroscience. Investigating brain data non-invasively recorded resting-state conditions has substantially enhanced our understanding the foundations cognitive functions. However, results more recent studies using functional magnetic resonance imaging suggest that...
Moyamoya is a rare chronic brain vascular disease with set of potential life-threatening consequences due to high probability stroke occurrence. Here we present case patient moyamoya disease, who has been dynamically observed over more than 4 years after the first manifestation her symptoms. In this study report fMRI and DTI findings obtained at final follow-up point, four two revascularization surgeries were successfully performed. Our lend support idea that surgery effective in preventing...