A5025537050- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Dementia and Cognitive Impairment Research
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Alzheimer's disease research and treatments
- Peripheral Neuropathies and Disorders
- Intensive Care Unit Cognitive Disorders
- Decision-Making and Behavioral Economics
- Hearing Impairment and Communication
- EEG and Brain-Computer Interfaces
- Autoimmune Neurological Disorders and Treatments
- Interpreting and Communication in Healthcare
- Neurological and metabolic disorders
- Neurobiology of Language and Bilingualism
- Genetic Neurodegenerative Diseases
- Health, Environment, Cognitive Aging
- Behavioral Health and Interventions
- Parkinson's Disease and Spinal Disorders
- Genetics and Neurodevelopmental Disorders
- Adenosine and Purinergic Signaling
- Ginger and Zingiberaceae research
- Child Nutrition and Feeding Issues
The University of Queensland
2018-2025
Royal Brisbane and Women's Hospital
2018-2025
NHS Lanarkshire
2024
QIMR Berghofer Medical Research Institute
2020
Mental Health Services
2020
FrontLine Service
2020
Westmead Hospital
2014-2016
The University of Sydney
2014-2016
Norfolk and Norwich University Hospitals NHS Foundation Trust
2015
Royal North Shore Hospital
2014
Apathy is a complex, behavioural disorder associated with reduced spontaneous initiation of actions. Although present in mild forms some healthy people, it pathological state conditions such as Alzheimer's and Parkinson's disease where can have profoundly devastating effects. Understanding the mechanisms underlying apathy therefore urgent concern but this has proven difficult because widespread brain changes neurodegenerative diseases make interpretation there no good animal model. Here we...
Differentiating idiopathic Parkinson disease (iPD) from other causes of tremor and parkinsonism based on clinical grounds can be challenging, particularly early in the course or case atypical presentations.
Abstract Background The behavioural variant of frontotemporal dementia (bvFTD) is a challenging diagnosis due to overlapping symptoms with psychiatric and other neurological conditions. Accordingly, misdiagnosis common. present study aimed identify clinical factors contributing misdiagnoses bvFTD by specialist physicians. Methods We retrospectively analysed 100 consecutive referrals physicians (primarily psychiatrists, neurologists geriatricians) tertiary cognitive disorders clinic...
Huntington's Disease (HD) is a debilitating neurodegenerative condition characterized by motor, cognitive and psychiatric abnormalities. Immune hyperactivity dysregulation are common in HD. In addition to the central nervous system, HD patients exhibit systemic innate immune activation inflammation, which has been shown contribute pathogenic effects of Huntingtin gene mutation. Upregulation inflammatory mediators including interferon gamma (IFN-γ) interleukin (IL)-8 observed animal disease...
This prospective cohort study, "Prospective Imaging Study of Ageing: Genes, Brain and Behaviour" (PISA) seeks to characterise the phenotype natural history healthy adult Australians at high future risk Alzheimer's disease (AD). In particular, we are recruiting midlife older with low genetic dementia discover biological markers early neuropathology, identify modifiable factors, establish very earliest phenotypic neuronal signs onset. PISA utilises prediction recruit enrich a follow them...
Impulsivity is a feature of many brain disorders. Although often defined as the predisposition to act with an inadequate degree deliberation, forethought or control, it has proven difficult measure. This may in part be because, increasingly, impulsivity recognized multifaceted construct, impulsive decisions potentially arising due number underlying mechanisms. Indeed, certain contexts, 'functional' promote effective, motivated behavior healthy participants. tasks have been developed study...
Introduction: Autoimmune encephalitis is a disorder associated with antibodies directed against central nervous system proteins variable clinical features. This study aims to add knowledge of the disease by reporting details cohort patients autoimmune in Queensland, Australia. Methodology: We surveyed diagnosed and managed through public hospitals Australia between 2010 end 2019. Cases were identified via case detection centralized diagnostic neuroimmunology laboratory (Division Immunology,...
ABSTRACT Background Monogenic causes of isolated dystonia are heterogeneous. Assembling cohorts affected individuals sufficiently large to establish new gene–disease relationships can be challenging. Objective We sought expand the catalogue monogenic etiologies for dystonia. Methods After discovery a candidate variant in multicenter exome‐sequenced cohort with dystonia, we queried online platforms and genomic data repositories worldwide identify subjects matching genotypic profiles. Results...
Abstract Impulsivity is often characterized by rapid decisions under risk, but most current tests of decision-making do not impose time pressures on participants' choices. Here we introduce a new traffic lights test which requires people to choose whether program risky, early eye movement before light turns green (earning them high rewards or penalty) wait for the responding obtain small reward instead. Young participants demonstrated bimodal responses: an early, high-risk and later,...
Deficits in memory are seen as a canonical sign of aging and prodrome to dementia older adults. However, our understanding age-related cognition brain morphology occurring throughout broader spectrum adulthood remains limited. We quantified the relationship between cognitive function (sulcal width, SW) using three cross-sectional observational datasets (PISA, AIBL, ADNI) from mid-life adulthood, assessing influence age, sex, amyloid (Aβ) genetic risk for dementia. The data comprised...
Creativity refers to the ability produce ideas or actions that are novel and useful, incorporating convergent divergent thinking. Currently, limited attention has been paid changes in creativity with disease progression (e.g. mild cognitive impairment Alzheimer's disease). Therefore, this study examined patterns of between healthy controls (n = 36), adults (MCI; n 23), (AD; 21). The explored whether performance on tasks can predict clinical group contributing processes. Various tests were...
Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing, autoimmune, inflammatory astrocytopathy. Rituximab for B-cell suppression common treatment NMOSD; however, large-scale randomised controlled trials are lacking. Objective Evaluate long-term efficacy and safety of rituximab NMOSD. Methods Retrospective observational study patients with NMOSD treated rituximab. Annualised relapse rates (ARRs) before during were evaluated; Modified Rankin Scores (mRS) measured as marker...
Background: Apathy, characterized by a quantifiable reduction in motivation or goal-directed behavior, is multidimensional syndrome that has been observed across many neurodegenerative diseases. Objective: To develop novel task measuring spontaneous action initiation (ie, nonverbal equivalent to speech tasks) and investigate the association between apathy executive functions such as voluntary of actions energization ability initiate sustain response). Method: We compared functioning...
Abstract Background Mild memory impairment, termed amnestic mild cognitive impairment (aMCI), is associated with rapid progression towards dementia in Parkinson’s disease (PD). Studies have shown hyperactivation of hippocampal DG/CA3 subfields during an episodic task as a biomarker aMCI related to Alzheimer’s disease. This project investigates the feasibility trial establish efficacy repurposed antiepileptic drug, levetiracetam, low doses putative treatment target and improve deficits PD....
Abstract This prospective cohort study, “Prospective Imaging Study of Ageing: Genes, Brain and Behaviour” (PISA) seeks to characterise the phenotype natural history healthy adult Australians at high future risk Alzheimer’s disease (AD). In particular, we are recruiting mid-life with low genetic dementia discover biological markers early neuropathology, identify modifiable factors, establish very earliest phenotypic neuronal signs onset. PISA utilises prediction recruit enrich a follow them...
Abstract Psychiatric symptoms are historically thought a relative contraindication to DBS for advanced Parkinson's disease ( PD ). However, in the case of drug‐induced mental illness, may provide an acceptable alternative treatment motor symptoms. This allows reduction pharmacological dopaminergic therapy that might otherwise cause negative psychiatric consequences. For example, is increasingly used ameliorate specific complications , such as impulse control disorders. We present series 3...
Hemiballism is a rare hyperkinetic movement disorder. The pathophysiology of hemiballism poorly understood, and there have been few reports neurophysiological recordings. authors report three cases with associated radiological findings. In patients 1 2, who were studied in the acute phase 4 14 days after presentation, irregularly timed predominantly long-duration electromyographic (EMG) bursts observed typically ranging from 200 to 1500 milliseconds duration occurring asynchronously or...
Skilled motor performance is essential for survival. Indeed, we often not only choose to learn skills because of some external reward, but also skilled movement, in and itself, satisfying. While dopamine known drive reward-based learning, it remains unclear whether implicated learning under conditions ostensibly driven by intrinsic rewards/motivation (i.e., the absence extrinsic feedback or reward). Here, investigated role skill guided internally determined signals success, using a task...