A5047013015- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Plant Genetic and Mutation Studies
- Electrohydrodynamics and Fluid Dynamics
- Respiratory viral infections research
- Antimicrobial Peptides and Activities
- Microbial Inactivation Methods
- Influenza Virus Research Studies
- Surface Modification and Superhydrophobicity
- Terahertz technology and applications
- Cell Adhesion Molecules Research
- 3D Printing in Biomedical Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cellular Mechanics and Interactions
University of Liverpool
2005-2017
Innate immune responses are critical in controlling viral infections. Viral proteins and nucleic acids have been shown to be recognized by pattern recognition receptors of the Toll-like receptor (TLR) family, triggering downstream signaling cascades that lead cellular activation cytokine production. DNA is sensed TLR9, TLRs 3, 7, 8 implicated innate RNA viruses virtue their ability sense double-stranded (ds) (TLR3) or single-stranded (murine TLR7 human TLR8). synthetic dsRNAs also a potent...
Understanding the influence of exposure biological systems to THz radiation is becoming increasingly important. There some evidence suggest that can important activities within mammalian cells. This study evaluated high peak power, low average power produced by ALICE (Daresbury Laboratory, UK) synchrotron source on human epithelial and embryonic stem The cells were maintained under standard tissue culture conditions, during which was delivered directly into incubator for various times. cell...
The cell-substrate interface plays a key role in the regulation of cell behaviour. Defining properties this is particularly important for human embryonic stem (hES) culture, because changes environment can regulate hES differentiation. It has been established that fibronectin-coated surfaces promote attachment, growth and maintenance undifferentiated phenotype cells. We investigated influence surface density adsorbed fibronectin on behaviour defined serum-free culture conditions demonstrated...
The success of stem cell therapies relies heavily on our ability to control their fate in vitro during expansion ensure an appropriate supply. biophysical properties the culture environment have been recognised as a potent stimuli influencing cellular behaviour. In this work we used advanced plasma-based techniques generate model substrates with controlled nanotopographical features 16 nm, 38 nm and 68 magnitude, three differently tailored surface chemical functionalities. effect these two...
Influenza viruses are serious respiratory pathogens, responsible for half a million deaths each year. The viral surface haemagglutinin (HA) protein has been shown to be an important determinant of pathogenicity. HA is the virion attachment and fusion protein, major target neutralizing antibodies; however, it also involved in triggering innate responses that may have impact on disease course. We examined role toll-like receptor (TLR) family influenza virus HA. TLR7 recently found mediate...
Summary Haematopoiesis is crucial for immunity because it results in the production of leucocytes. Bacterial and viral infections alter leucocyte by promoting granulopoiesis or lymphopoiesis. Recent studies suggest that changes may be caused effects inflammatory responses on differentiation haematopoietic progenitors bone marrow. We investigated mechanisms through which infection regulates formation marrow‐derived dendritic cells (BMDCs) vitro . mimicked stimulating developing with molecules...