A5100607652- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Studies
- Colorectal Cancer Treatments and Studies
- Adipose Tissue and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Entrepreneurship Studies and Influences
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Hepatitis B Virus Studies
- Traditional Chinese Medicine Analysis
- Medical Research and Treatments
- Hepatitis C virus research
- Acute Myocardial Infarction Research
- Metabolism, Diabetes, and Cancer
- Cardiovascular Function and Risk Factors
- Genetic factors in colorectal cancer
- Private Equity and Venture Capital
- Cancer Mechanisms and Therapy
- AI in cancer detection
- Liver Disease and Transplantation
- Medical Imaging Techniques and Applications
- Plant-based Medicinal Research
- Cardiovascular Health and Risk Factors
- Exercise and Physiological Responses
- Diet and metabolism studies
Sun Yat-sen University
2020-2025
Sun Yat-sen University Cancer Center
2020-2025
Deyang Stomatological Hospital
2024
Dalian University
2012-2024
China Electric Power Research Institute
2024
North China Electric Power University
2024
Nanjing Medical University
2013-2024
Nanjing Maternity and Child Health Care Hospital
2024
Wuhan Sports University
2011-2023
Huazhong University of Science and Technology
2007-2023
Beclin-1 is a key modulator bridging autophagy, apoptosis and differentiation. This study investigated the expression of beclin-1 in human colon cancers its association with clinicopathological characteristics. A total 115 cases cancer tissues intact follow-up data were obtained from patients stage IIIB. The nest adjacent normal tissue was examined immunohistochemistry. results showed immunostaining distributed plasma-membrane, cytoplasm nucleus tumor cells, which occurred 98 (85.2%)...
The programmed death-1 (PD-1)/PD-L1 pathway plays important roles in immune responses and peripheral tolerance. Under pathological conditions, this can suppress protective T cell induce system disorders. Endometriosis (EM) is an estrogen-dependent, immune-associated disease. expression of PD-1 PD-L1 has been studied a variety cancers autoimmune diseases. Few studies, however, have attempted to explore their the possibility that they are regulated by estrogen EM. Eutopic ectopic endometria...
Leucine aminopeptidase 3 (LAP3), an M1 member of leucine aminopeptidase, was reported to be significantly upregulated in serum nonalcoholic fatty liver disease (NAFLD) patients. However, the underlying mechanisms LAP3 NAFLD pathogenesis are still unknown. We aim investigate role and explore whether has potential a candidate biomarker for diagnosis.Liver tissues from NASH rats, patients with were obtained evaluate expression. Detection GSSG/GSH, intracellular reactive oxygen species (ROS),...
The increased oxidative stress is usually observed in obese population, but the control of body weight by calorie restriction and/or exercise training can ameliorate stress. In order to evaluate response and dietary adolescents, a total 20 volunteers were enrolled 4-week intervention program including restriction. Body compositions blood samples analysed before after intervention, biomarkers associated with examined. After coupled restriction, physical composition parameters mass, mass index...
Identifying breast cancer (BC) patients with germline susceptibility gene (gBRCA) mutation is important. The current criteria for testing BC remain controversial. This study aimed to develop a nomogram incorporating ultrasound radiomic features and clinicopathological factors predict gBRCA mutations in BC. In this retrospective study, 497 women who underwent genetic from March 2013 May 2022 were included, including 348 training (84 264 without mutation) 149 validation(36 113 mutation)....
Objective Electroconvulsive therapy (ECT) has often been applied to augment antipsychotics for schizophrenia patients. However, the underpinning mechanism is still unclear. Previous studies of major depressive disorder reported an increase in γ-aminobutyric acid (GABA) after ECT. The present study investigated effects ECT on medial prefrontal GABA using a proton magnetic resonance spectroscopy. Methods Inpatients fulfilling diagnostic criteria ( Diagnostic and Statistical Manual Mental...
Rationale: Oseltamivir-induced alimentary tract hemorrhage and liver injury are rarely reported in children adult individuals. In this study, we described the clinical features outcomes of oseltamivir-induced a child. Patient concerns: Here, present case 6-year-old Asian boy with hematemesis elevated alanine aminotransferase (ALT) (80 U/L) aspartate (AST) (69 levels on day 2 oseltamivir administration. The presence was diagnosed. ALT level reached 1931.3 U/L, accompanied by an increase total...
Most high-performance computing (HPC) clusters use a global parallel file system to enable high data throughput. The is typically centralized and its storage media are physically separated from the compute cluster. Compute nodes as clients of often additionally equipped with SSDs. node internal rarely well-integrated into I/O workflows. How make full flexible these therefore valuable research question.
An experiment was conducted to investigate the effect of niacin supplementation on hepatic lipid metabolism in rabbits. Rex Rabbits (90 d, n = 32) were allocated two equal treatment groups: Fed basal diet (control) or fed with additional 200 mg/kg (niacin). The results show that significantly increased levels plasma adiponectin, apoprotein B and leptin receptors mRNA (p<0.05), but decreased fatty acid synthase activity adiponectin receptor 2, insulin acetyl-CoA carboxylase (p<0.05). Plasma...
In high-performance computing (HPC), data and metadata are stored on special server nodes client applications access the servers’ through a network, which induces network latencies resource contention. These typically equipped with (slow) magnetic disks, while store temporary fast SSDs or even non-volatile main memory (NVMM). Therefore, full potential of parallel file systems can only be reached if side storage devices included into overall architecture. this article, we propose an...
Interstitial lung disease with cancer (ILD-LC) is rare and its management has not been fully described. This study aimed to investigate the prognosis of ILD-LC patients in China.The present analysis a retrospective real-world cohort study. Clinical data were obtained from 3 hospitals China. The overall survival (OS) was analyzed. Univariate multivariate regression analyses performed.One hundred eighty-four included biased toward male (85.3%), smokers (75.5%), idiopathic pulmonary fibrosis...
This study investigated the characteristics of oxaliplatin-induced hypersensitivity reactions (HSRs) and evaluated efficacy premedication for controlling HSRs among colorectal cancer patients. A retrospective was performed on clinical records 291 patients with in The Tenth People's Hospital Shanghai from January 2008 to 2016. Patients who experienced oxaliplatin were compared those did not. total received oxaliplatin, 39 (13.40%) experiencing HSRs. Oxaliplatin-free interval dexamethasone...
Objectives: To evaluate the effect of Yugengtongyu granules on reducing incidence adverse cardiovascular events and improving quality life (QOL) in patients with stable coronary artery disease (SCAD). Methods: A double-blind randomized controlled trial was conducted among SCAD population. One hundred fourteen were randomly assigned to experimental group (n = 57) control following block design. Combined basis standard treatment SCAD, received or placebo, respectively, twice daily for 6 months...
e18504 Background: Watson for Oncology (WFO) is a cognitive computing system developed by IBM to assist in tumor therapy which was trained the Memorial Sloan Caitlin Cancer Center (MSKCC) four years. It helps oncologists or clinic team make therapeutic decisions providing evidence-based treatment options recommendations with priority and personality. There have been some reports that provided WFO are highly consistent. Therefore, may become an important tool help options. Methods: A new...
Noninvasive fibrosis tests are highly needed but have not been well studied in chronic hepatitis B patients with normal or minimally elevated alanine aminotransferase (ALT) levels. This study is aimed at developing a noninvasive score system to predict liver these patients. HBeAg-positive ALT levels of <80 IU/l and histology (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>290</mml:mn></mml:math>) were assigned training...
Purpose Accurate determination of the primary tumor extension nasopharyngeal carcinoma (NPC) by 18 F-FDG PET/CT is limited high physiological uptake in surrounding area, especially brain tissue. We aimed to assess whether 11 C-choline could improve accuracy T staging and volume delineation for NPC patients. Methods Patients with pathologically confirmed diagnosis were enrolled. The each patient was evaluated PET/CT, contrast-enhanced MRI. PET/CT-based ( V PET ) measured 3 threshold methods,...
Objectives: Comorbid of non-alcoholic fatty liver disease (NAFLD) in chronic hepatitis B (CHB) patients is common but no simple noninvasive diagnostic methods are available for the identification. This study aims to develop a nomogram accurate detection NAFLD CHB patients. Patients and methods: included 535 biopsy-proven with or without comorbid NAFLD. Independent risk factors were identified by multivariate logistic regression analysis. The then incorporated into nomogram. Performance was...
In order to examine the effect of 4-week combinatorial intervention with exercise training and dietary restriction on serum fatty acids, explore correlation intervention-induced improvement acid profile reduction body fat arterial stiffness.Thirty-three obese adolescents were randomized into (n = 19) control 14) groups. The participants from group subjected while maintained regular activities diet habits. Anthropometry, acids stiffness measured before after intervention.The upon revealed...
The skin, the body's largest organ, plays an important role in biotransformation/detoxification and elimination of xenobiotics endogenous toxic substances, but its oxidative stress insulin resistance is unclear. We investigated relationship between skin detoxification stress/insulin by examining burn-induced changes nicotinamide degradation. Rats were divided into four groups: sham-operated, sham-nicotinamide, burn, burn-nicotinamide. received intraperitoneal glucose injection (2 g/kg) with...