A5101968020- AI in cancer detection
- Liver Disease Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Ovarian cancer diagnosis and treatment
- Hepatitis C virus research
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Intraperitoneal and Appendiceal Malignancies
- Advanced Welding Techniques Analysis
- Colorectal and Anal Carcinomas
- MRI in cancer diagnosis
- Cell Image Analysis Techniques
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Hepatitis Viruses Studies and Epidemiology
- Stock Market Forecasting Methods
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Immune Cell Function and Interaction
Sun Yat-sen University
2019-2025
Sun Yat-sen University Cancer Center
2019-2025
Tianjin Third Central Hospital
2022-2025
Tianjin Medical University
2022-2025
Tianjin University
2025
State Key Laboratory of Oncology in South China
2019-2024
Chongqing Jiaotong University
2024
Chinese University of Hong Kong
2023
Huazhong University of Science and Technology
2023
Sun Yat-sen Memorial Hospital
2023
Abstract Ovarian cancer, a group of heterogeneous diseases, presents with extensive characteristics the highest mortality among gynecological malignancies. Accurate and early diagnosis ovarian cancer is great significance. Here, we present OvcaFinder, an interpretable model constructed from ultrasound images-based deep learning (DL) predictions, Ovarian–Adnexal Reporting Data System scores radiologists, routine clinical variables. OvcaFinder outperforms DL area under curves (AUCs) 0.978,...
An immunosuppressive tumor microenvironment in ovarian cancer facilitates progression and resistance to immunotherapy. The function of MYB Proto-Oncogene Like 2 (MYBL2) the remains largely unexplored.A syngeneic intraovarian mouse model, flow cytometry analysis, immunohistochemistry were used explore biological MYBL2 immune escape. Molecular biochemical strategies-namely RNA-sequencing, western blotting, quantitative reverse transcription-polymerase chain reaction (qRT-PCR), enzyme-linked...
Abstract Platinum resistance represents a major barrier to the survival of patients with ovarian cancer (OC). Cdc2‐like kinase 2 (CLK2) is protein associated oncogenic phenotype and development in some solid tumors. However, exact role underlying mechanism CLK2 progression OC currently unknown. Using microarray gene expression profiling immunostaining on tissues, we found that was upregulated tissues short platinum‐free interval patients. Functional assays showed protected cells from...
Although pegylated interferon α-2b (PEG-IFN α-2b) therapy for chronic hepatitis B has received increasing attention, determining the optimal treatment course remains challenging. This research aimed to develop an efficient model predicting (IFN) course. Patients with B, undergoing PEG-IFN monotherapy or combined NAs (Nucleoside Analogs), were recruited from January 2018 December 2023 at Tianjin Third Central Hospital. All patients achieved surface antigen (HBsAg) clearance post-treatment....
Functional cure strategies based on interferon therapy for chronic hepatitis B (CHB) are gaining increasing attention among clinicians. However, studies investigating the duration of response after achieving HBsAg clearance with treatment limited. This study aims to explore patterns sustained following in patients treated pegylated alpha-2b (PegIFNα-2b) through long-term follow-up, providing guidance clinical practice. We collected data from CHB who achieved and were either PegIFNα-2b...
Background: The systemic immune-inflammation index (SII) has been identified as a predictor of chemotherapy efficacy for variety cancers, and we aimed to determine its ability predict the response long-term prognosis patients with cervical squamous cell carcinoma (CSCC) who have underwent platinum-based neoadjuvant (NACT). Methods: date from 210 (133 in training cohort 77 validation cohort) CSCC received NACT were analyzed retrospectively. association between SII pathological complete (pCR)...
Identifying breast cancer (BC) patients with germline susceptibility gene (gBRCA) mutation is important. The current criteria for testing BC remain controversial. This study aimed to develop a nomogram incorporating ultrasound radiomic features and clinicopathological factors predict gBRCA mutations in BC. In this retrospective study, 497 women who underwent genetic from March 2013 May 2022 were included, including 348 training (84 264 without mutation) 149 validation(36 113 mutation)....
Abstract Small cell cervical carcinoma (SCCC) is the most common neuroendocrine tumor in female genital tract, with an unfavorable prognosis and lacking evidence‐based therapeutic approach. Until now, distinct subtypes immune characteristics of SCCC combined genome transcriptome have not been described. We performed genomic ( n = 18), HPV integration transcriptomic sequencing 19) samples. assessed differences between conventional cancer, other small carcinomas, through bioinformatics...
To evaluate the diagnostic performance of a deep learning (DL) model for breast US across four hospitals and assess its value to readers with different levels experience.
Abstract Objective Immunotherapy has led to changes in cervical cancer guidelines. Therefore, additional biomarkers identify the ideal patient who would experience most benefit may be important. Methods We retrospectively collected 208 patients with R/M CC and recorded clinicopathologic information, peripheral blood markers treatments analyze prognostic factors of clinical outcomes. Response rate comparison, univariate, multivariate analyses were performed assess efficacy different factors....
Objective: To evaluate the interobserver agreement, diagnostic value, and associated clinical factors of automated breast ultrasound (ABUS) coronal features in differentiating lesions. Materials Methods:This study enrolled 457 pathologically confirmed lesions 387 female (age, 46.4 ± 10.3 years), including 377 masses 80 non-mass (NMLs).The unique features, retraction phenomenon, hyper-or hypoechoic rim (continuous or discontinuous), skipping sign, white wall were defined recorded.The...
Objective: To develop a nomogram for predicting lymph node metastasis (LNM) in patients with epithelial ovarian cancer (EOC). Methods: Between December 2012 and August 2022, EOC who received computed tomography (CT) serological examinations were treated upfront staging or debulking surgery included. Systematic pelvic para-aortic lymphadenectomy was performed all patients. Univariate multivariate analysis used to identify significant risk factors associated LNM. A then constructed assess the...
Minimal hepatic encephalopathy (MHE) has a substantial impact on the clinical outcomes and quality of life (QOL) patients with cirrhosis. However, timely diagnosis intervention are challenging due to sophisticated diagnostic methods. In this study, 673 healthy controls 905 cirrhosis were screened, 660 757 cirrhosis, divided into test (292 patients) validation (465 cohort, analyzed after screening. A model Stroop (Stroop-CN) was constructed by multivariate linear regression based results...
The diagnostic value of axillary ultrasound (US) for level II and III lymph node metastasis after dissection invasive breast cancer is currently not clear. objectives this study were to retrospectively analyze the axillar US compare it with palpation features nodes that are predictive metastatic recurrence during follow-up.Cases or detected by between January 2005 December 2017 at a center divided into 2 groups according retrospective analysis findings: potential malignancy group follow-up...
To summarize the risk factors and emphasize prognostic importance of site recurrent neuroendocrine cervical cancer (NECC).We enrolled 88 patients who developed recurrence after radical surgery for pathological stage I-IVa primary NECC between January 2003 30 December 2020 classified these cases into 7 groups based on initial recurrence. The post-recurrence survival (PRS) were analyzed by Kaplan-Meier Cox regression methods.Among patients, nearly all (95.50%) experienced progression within 3...
Objective: To compare the differences in prevalence of mild micro-hepatic encephalopathy (MHE) among patients with cirrhosis by using psychometric hepatic score (PHES) and Stroop smartphone application (Encephal App) test. Methods: This prospective, multi-center, real-world study was initiated National Clinical Medical Research Center for Infectious Diseases Portal Hypertension Alliance registered International ClinicalTrials.gov (NCT05140837). 354 cases were enrolled 19 hospitals across...
Previous studies have highlighted significant advancements in multimodal fusion. Nevertheless, such methods often encounter challenges regarding the efficacy of feature extraction, data integrity, consistency dimensions, and adaptability across various downstream tasks. This paper proposes a generalized fusion method (GMF) via Poisson-Nernst-Planck (PNP) equation, which adeptly addresses aforementioned issues. Theoretically, optimization objective for traditional tasks is formulated...
Galvanized high-strength steel has emerged as a key focus in automotive lightweighting research. During resistance spot welding of galvanized steel, the phenomenon liquid metal embrittlement (LME) can occur, which is characterized by appearance irregular cracks on weld surface. However, impact LME mechanical properties joints remains unclear. This study investigates and its effects performance spot-welded using QP980 subject. By combining theoretical analysis, experimental methods,...