A5026490198- Renal Transplantation Outcomes and Treatments
- HIV/AIDS drug development and treatment
- Prostate Cancer Treatment and Research
- Neurotransmitter Receptor Influence on Behavior
- Pharmacological Effects and Toxicity Studies
- Bipolar Disorder and Treatment
- Cancer Genomics and Diagnostics
- Hematopoietic Stem Cell Transplantation
- Schizophrenia research and treatment
- Estrogen and related hormone effects
- Bioinformatics and Genomic Networks
- Cutaneous lymphoproliferative disorders research
- Breast Cancer Treatment Studies
- Electrolyte and hormonal disorders
- Gene expression and cancer classification
- Cancer Treatment and Pharmacology
- Receptor Mechanisms and Signaling
- Blood Coagulation and Thrombosis Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Statistical Methods in Clinical Trials
- Renal Diseases and Glomerulopathies
- Acute Lymphoblastic Leukemia research
- Autoimmune Bullous Skin Diseases
- Hemophilia Treatment and Research
Pfizer (United States)
2025
University of North Carolina at Chapel Hill
2019-2022
Icahn School of Medicine at Mount Sinai
2018
Tisch Cancer Institute
2018
University of Pittsburgh
2017
University of California, Santa Cruz
2010
Alopecia areata (AA) is an autoimmune disease characterized by hair loss that can negatively impact quality of life. AA has a significant pediatric prevalence; however, no systemic treatments are approved for in patients aged < 12 years. Ritlecitinib, JAK3/TEC family kinase inhibitor, to treat adults and adolescents with severe ≥ This study evaluated ritlecitinib pharmacokinetic (PK) parameters safety 6 In this single-group, uncontrolled, open-label study, participants received 20 mg once...
Abstract Resilience is a critical leadership competency directly linked to engagement, sustainable innovation, and productivity. This Commentary presents resilience concepts using the Benatti Resiliency Model ® , which comprises five inter‐related dimensions: Well‐being, Self‐awareness, Brand, Connection, Innovation. Trust discussed as competency, with three levels: self‐trust, trust in relationships at team level, community trust. The concept of Ikigai, representing intersection what one...
Tacrolimus exhibits high inter-patient pharmacokinetics (PK) variability, as well a narrow therapeutic index, and therefore requires drug monitoring. Germline mutations in cytochrome P450 isoforms 4 5 genes (CYP3A4/5) the ATP-binding cassette B1 gene (ABCB1) may contribute to interindividual tacrolimus PK which impact clinical outcomes among allogeneic hematopoietic stem cell transplantation (HSCT) patients. In this study, 252 adult patients who received for acute graft versus host disease...
Abstract Tacrolimus is a calcineurin inhibitor used to prevent acute graft versus host disease in adult patients receiving allogeneic hematopoietic stem cell transplantation (HCT). Previous population pharmacokinetic (PK) models have been developed solid organ transplant, yet none exists for HCT. The primary objectives of this study were (1) use previously published PK model who underwent kidney transplant and apply it HCT; (2) evaluate model‐predicted tacrolimus steady‐state trough...
Cocaine (COC) is a psychostimulant with high potential for abuse and addiction. Risk COC use disorder driven, in part, by genetic factors. Animal models of addiction-relevant behaviors have proven useful studying both nongenetic contributions to drug response. In previous study, we examined initial locomotor sensitivity genetically diverse inbred mouse strains. That work highlighted the relevance pharmacokinetics (PK) response but was limited single dose two sampling points. The objective...
Abstract Introduction Haemophilia A patients require perioperative clotting factor replacement to limit excessive bleeding. Weight‐based dosing of Factor VIII (FVIII) does not account for inter‐individual pharmacokinetic (PK) variability, and may lead suboptimal FVIII exposure. Aim To perform an external validation a previously developed population PK (popPK) model in haemophilia patients. Methods retrospective chart review identified at the University North Carolina (UNC) between April 2014...
To develop the first population pharmacokinetic (PopPK) model for oral tacrolimus in adult allogeneic hematopoietic cell transplant (allo-HCT) recipients, we conducted a prospective clinical pharmacology study among real-world patients (NCT04645667). This commentary describes challenges associated with planning and executing during global pandemic, provides insights on how to effectively communicate, remain adaptable institutional changes, improve consent rate, accommodate new workflows...
Background Selective serotonin reuptake inhibitors (SSRIs) are first-line pharmacotherapy for mood and anxiety disorders. The common mechanism of drugs in this class is antagonism the transporter. Within transporter gene SLC6A4, two polymorphic sites termed 5-HTTLPR STin2 proposed to have functional consequences thus been attractive candidates pharmacogenetic studies SSRI efficacy tolerability studies. Objective This review summarizes approximately 15 years study these polymorphisms as...
Aim: To evaluate the potential impact of preemptive multigene pharmacogenomic (PGx) testing on medication prescribing in real-world clinical settings. Patients & methods: Prescription frequencies for 65 medications with actionable PGx recommendations were collected 215 percutaneous coronary intervention (PCI) and 131 allogeneic hematopoietic cell transplant (allo-HCT) patients. A simulation projected number PGx-guided opportunities. Results: In PCI allo-HCT patients, respectively, 66.5 90.1%...
Abstract Large-scale whole-genome assays such as aCGH and expression profiling are providing an overabundance of data on disease states, yet much the information is not relevant to driving disease. There a need for generating concise explanatory modules with powerful predictive results. Here we describe semi-supervised machine-learning method classifying -omics associated clinical features. Using NMF matrix convoluted step-wise into two matrices; table k “metagenes” containing coefficients...
Abstract Triple negative breast cancer (TNBC), which is characterized by lack of expression estrogen receptor (ER), progesterone (PR) and human epidermal growth factor type 2 (HER2), frequently associated with aggressive behavior adverse patient outcomes comprises a heterogeneous subgroup tumors diverse genomic features. Currently, TNBC patients are managed only few approved therapies treatment strategies, including taxane-anthracycline chemotherapy. However, there women whose extremely...
305 Background: The Strata trial (NCT03061305) is a multi-institutional precision oncology collaboration structured as an observational protocol that aims to match patients genomically-guided therapies. Methods: Selected University of North Carolina (UNC) metastatic prostate cancer (mPC) were enrolled on this IRB-approved study. Formalin fixed paraffin-embedded primary tumor specimens, without matched germline controls, sent for targeted next generation sequencing (NGS) detect actionable...
e16582 Background: The Strata Trial (NCT03061305) is a multi-institutional precision oncology collaboration structured as an observational protocol that aims to match patients genomically guided therapies. Methods: Selected University of North Carolina (UNC) metastatic prostate cancer (mPC) were enrolled on this IRB-approved study. Formalin fixed paraffin-embedded primary tumor specimens, without matched germline controls, sent for targeted next generation sequencing (NGS) detect actionable...