A5103176336- Facial Rejuvenation and Surgery Techniques
- Advanced materials and composites
- Diamond and Carbon-based Materials Research
- Orthodontics and Dentofacial Orthopedics
- Electromagnetic Fields and Biological Effects
- Facial Nerve Paralysis Treatment and Research
- Body Image and Dysmorphia Studies
- Bone Tissue Engineering Materials
- Microbial Inactivation Methods
- Interactive and Immersive Displays
- Additive Manufacturing and 3D Printing Technologies
- Reconstructive Facial Surgery Techniques
- Temporomandibular Joint Disorders
- Head and Neck Cancer Studies
- Cleft Lip and Palate Research
- Aluminum Alloys Composites Properties
- Bone Metabolism and Diseases
- Thermal properties of materials
- Wnt/β-catenin signaling in development and cancer
- TGF-β signaling in diseases
- Craniofacial Disorders and Treatments
- Dental Implant Techniques and Outcomes
- Semiconductor materials and devices
- Dental Radiography and Imaging
- Innovative Human-Technology Interaction
Taiyuan University of Technology
2024-2025
China Mobile (China)
2023-2025
Materials Science & Engineering
2025
Peking University
2025
Peking University Third Hospital
2025
Hainan Medical University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2022
Peking Union Medical College Hospital
2020-2022
Northwest University
2016-2019
Ministry of Education of the People's Republic of China
2016-2019
Although the genetic spectrum of human colorectal cancer (CRC) is mainly characterized by APC, KRAS and TP53 mutations, driver genes in tumor initiation have not been conclusively demonstrated. In this study, we aimed to identify novel markers for CRC. We performed exome analysis sporadic (sCRC) coding regions screen loss function (LoF) mutation genes, carried out systems-level approaches confirm top rank gene study. identified BMP5 an early event Deep sequencing was mutated 7.7% (8/104)...
Abstract Thermal conductive polymer composites have broad application prospects in the field of thermal management. However, due to intrinsically low conductivity polymers, even if fillers with high mass fraction are filled, cannot be significantly improved. In this paper, bimodal diamond particles (70 wt.% 150 μm and 22 25 μm) were incorporated into phenolic resin construct continuous heat transfer pathways by close packing, thereby enhancing its conductivity. The results indicated that...
A new strategy coupling Fe etching with Ar+ bombardment was proposed and carried out on the single-crystal diamond (SCD) surface for enhancing electrical properties of by dual effects defects impurity elements. Scanning electron microscope, energy dispersive x-ray spectrum, diffractometer, Raman spectroscopy, Hall measurements were performed to investigate modified structure field emission (EFE) performance. The results indicated that concentric circle patterns accompanying propitious clouds...
Carbon nanotubes (CNTs) are promising biomaterials in the medical field, especially tissue engineering of bone. However, use CNTs is largely confined by its unfavorable solubility and toxicity. To improve biocompatibility CNTs, functionalization has been proven to be an effective strategy. Although various functionalized have extensively studied, only few desired qualities. We compared toxicity several multi-walled carbon (MWCNTs) on rat bone-marrow derived stem cells (BMSCs). Cell...
Abstract Background The assessment of skin aging through measurements faces limitations, making perceived age evaluation a more valuable and direct tool for assessing aging. Given that the process markedly affects appearance eye contour, characterizing region could be beneficial assessment. This study aimed to analyze age‐correlated changes in contour within Chinese Han female population develop, validate, apply multiple linear regression model predicting age. Materials methods A naïve panel...
Mutations in transforming growth factor beta receptor II (TGFBR2) are detected up to 30% of overall colorectal cancer (CRC). Dysregulation some microRNAs participated the CRC pathogenesis. In this study, we used gene ontology analyses, Kyoto Encyclopedia Genes and Genomes pathway analyses set enrichment analysis indicate that miR-3191 was involved regulation (TGF-BETA) signal CRC. These bioinformatics results were supported by data obtained from samples experiments vitro. The luciferase...
Ras-association domain family protein 6 (RASSF6) is a member of tumor suppressor RASSFs with wide range function from RAS interaction, Hippo signaling involvement to cell cycle and apoptosis regulation. RASSF6 reported inactivated in various types cancer. However, whether associated colorectal cancer the underlying mechanisms have yet be investigated. In our previous exome sequencing study, we found somatic loss-of-function (LoF) mutation one sporadic (sCRC) patient, two missense mutations...
Calcium phosphate (BCP) ceramic is a promising material in bone regeneration because it was proved biocompatible, osteoconductive, osteoinductive, and effective. Although manifests favorable characteristics critical-sized defects repair, the mechanism of its osteoinduction still unclear. In present study, we studied ectopic formation, with interest Notch signaling pathway. BCP ceramics or without inhibitor RO4929097 were cocultured marrow-derived stem cells vitro. The expression osteogenesis...
Sporadic colorectal cancer (sCRC) is one of the leading causes death worldwide. As a highly heterogeneous complex disease, currently reported classical genetic markers for sCRC, including APC , KRAS BRAF and TP53 gene mutations epigenetic alterations, can explain only some sCRC patients. Here, we first deleterious c.551C>T mutation in SARDH sCRC. was identified as novel tumor suppressor abnormally decreased at both transcriptional translational level. mRNA levels were also down‐regulated...
Power-line frequency electromagnetic field (PF-EMF) was reported as a human carcinogen by some epidemiological research, but the conclusion is lack of robust experiment evidence. To identify effects long-term PF-EMF exposure on cell behavior, Balb/c 3T3 cells in exponential growth phase were exposed or sham-exposed to 50 Hertz (Hz) at 2.3 mT for 2 hours (h) one day, 5 days every week. After 11 weeks exposure, collected instantly. Cell morphology observed under invert microscope and Giemsa...
To evaluate surgical outcomes of modified Z-epicanthoplasty with blepharoplasty that we previously reported from the patient's perspective using patient-reported outcome measures (PROMs) and patient satisfaction scores.A total patients (n=180) who underwent surgery between January 2013 June 2016 were randomly selected. Standardized forms (total score, 40) validated PROMs questionnaires 12) sent to for completion. assesses severity scarring, pain asymmetry, as well functional appearance...
The biological effects of electromagnetic pulse (EMP) on the brain have been focused for years. It was reported that gelatinase played an important role in maintaining function through regulating permeability blood–brain barrier (BBB). To investigate EMP BBB, vitro BBB model established using primary cultured rat microvascular endothelial cells (BMVEC), astrocytes and half-contact culture these a transwell chamber. Cultured supernatant were collected at different time points after exposure...