A5043792577- Horticultural and Viticultural Research
- MicroRNA in disease regulation
- Fermentation and Sensory Analysis
- Circular RNAs in diseases
- Plant Pathogens and Fungal Diseases
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- Viral gastroenteritis research and epidemiology
- Phytochemicals and Antioxidant Activities
- Plant-Microbe Interactions and Immunity
- Conducting polymers and applications
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- RNA regulation and disease
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Probiotics and Fermented Foods
- Hepatitis Viruses Studies and Epidemiology
- Organic Electronics and Photovoltaics
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Genomics and Phylogenetic Studies
- Metamaterials and Metasurfaces Applications
- Biosensors and Analytical Detection
- Adenosine and Purinergic Signaling
Guangzhou Medical University
2020-2024
Chinese Academy of Agricultural Sciences
2021-2024
Case Western Reserve University
2024
First Affiliated Hospital of Wannan Medical College
2024
Zhengzhou Fruit Research Institute
2021-2024
Key Laboratory of Guangdong Province
2023
Zhengzhou City Hospital
2021
Tsinghua University
2019-2020
Hebei Medical University
2014-2020
Xingtai People's Hospital
2020
Although the genetic spectrum of human colorectal cancer (CRC) is mainly characterized by APC, KRAS and TP53 mutations, driver genes in tumor initiation have not been conclusively demonstrated. In this study, we aimed to identify novel markers for CRC. We performed exome analysis sporadic (sCRC) coding regions screen loss function (LoF) mutation genes, carried out systems-level approaches confirm top rank gene study. identified BMP5 an early event Deep sequencing was mutated 7.7% (8/104)...
Grape white rot, a devastating disease of grapevines caused by Coniella diplodiella (Speg.) Sacc., leads to significant yield losses in grape. Breeding grape cultivars resistant rot is essential reduce the regular use chemical treatments. In recent years, Chinese species have gained more attention for breeding due their high tolerance various biotic and abiotic factors along with changing climatic conditions. this study, we employed whole-genome resequencing (WGR) genotype parents 'Manicure...
Abstract Background Circular RNAs (circRNAs) have been reported to play vital roles in colorectal cancer (CRC). However, only a few circRNAs experimentally validated and functionally described. In this research, we aimed reveal the functional mechanism of circCSPP1 CRC. Methods 36 DOX sensitive resistant CRC cases participated study. The expression circCSPP1, miR-944 FZD7 were detected by quantitative real time polymerase chain reaction (qRT-PCR) protein levels FZD7, MRP1, P-gp LRP western...
Evaluation of volatile aroma compounds from Chinese wild grape species aimed to explore new via fruit aroma. In this study, the organic (VOCs) ten cultivars belonging nine different were detected, by using headspace solid-phase microextraction with GC-MS. studied along table (Muscat Hamburg, Concord) and wine (Cabernet Sauvignon) origins. Total forty-five upon which several VOCs including pentanoic acid, cyclobutyl ester, maltol, (+)-neoisomenthol, 8-methyloctahydrocoumarin detected in...
The pomegranate fruit is valued for its nutritional and medicinal properties, the composition content of primary secondary metabolites are main factors impacting properties. However, a deep understanding in different parts still lacking. Here, peel, aril, seed mature fruits were analyzed separately to compare metabolic component differences using UPLC/MS-MS. A total 858 belonging 11 classes identified, which flavonoids, such as delphinidin-3-O-glucoside cyanidin-3-O-glucoside; tannins,...
Abstract Background Colorectal cancer (CRC) is one of the third normal malignancy worldwide. Taurine-upregulated gene 1 (TUG1), a member long noncoding RNAs (lncRNAs), has been reported to be involved in various cancers. However, mechanism underlying TUG1 progression CRC remains unclear. Methods The expression TUG1, microRNA-542-3p (miR-542-3p), and tribbles homolog 2 (TRIB2) tissues cells (LoVo HCT116) were detected by quantitative real-time PCR (qRT-PCR). Methyl thiazolyl tetrazolium...
Salicylic acid (SA) is a well-studied phenolic plant hormone that plays an important role in defense against the hemi-biothrophic and biothrophic pathogens depends on living cells of host for successful infection. In this study, pathogenesis test was performed between Vitis davidii V. vinifera cultivars grape white rot disease (Coniella diplodiella). found to be resistant disease. SA contents were higher cultivar after different time points. RNA-seq analysis conducted susceptible grapevine...
Ras-association domain family protein 6 (RASSF6) is a member of tumor suppressor RASSFs with wide range function from RAS interaction, Hippo signaling involvement to cell cycle and apoptosis regulation. RASSF6 reported inactivated in various types cancer. However, whether associated colorectal cancer the underlying mechanisms have yet be investigated. In our previous exome sequencing study, we found somatic loss-of-function (LoF) mutation one sporadic (sCRC) patient, two missense mutations...
Background . Pyroptosis, a novel form of inflammatory programmed cell death, was recently found to be cause mucosal barrier defect. In our pervious study, CD147 expression documented increase in intestinal tissue bowel disease (IBD). Objective The aim this study determine the function serum pyroptosis. Methods group consisted 96 cases. centration CD147, IL-1 β , and IL-18 levels assessed by ELISA. Real-time PCR WB were performed analyze effect on Results results showed that induced...
Grape white rot caused by Coniella diplodiella (Speg.) affects the production and quality of grapevine in China other grapevine-growing countries. Despite importance C. as a serious disease-causing agent grape, genome information molecular mechanisms underlying its pathogenicity are poorly understood. To bridge this gap, 40.93 Mbp strain WR01 was de novo assembled. A total 9,403 putative protein-coding genes were predicted. Among these, 608 248 potentially secreted proteins candidate...
Haplotype analysis has been increasingly used to study the genetic basis of human diseases, but models for characterizing interactions between haplotypes from different chromosomal regions have not well developed in current literature. In this article, we describe a statistical model testing haplotype-haplotype diseases with case-control association design. The is formulated on contingency table which cases and controls are typed same set molecular markers. By integrating well-established...
Diarrhea remains a significant health threat to children under five years of age. The study aims systematically elucidate the global burden diarrhea in children, providing scientific insights for effective prevention and control strategies.
The aim of the study is to investigate effects miR-34a targeted at PAI-1 on urinary microalbumin and renal function in hypertensive mice.Twenty specific-pathogen-free (SPF) BPN/3J mice were selected normal group, 120 SPF BPH/2J evenly divided into model negative control mimic inhibitor Si-PAI-1 + group. qRT-PCR was used detect expression mRNA. protein expressions PAI-1, angiotensin-converting enzyme (ACE) ACE2 detected by Western blot. Serum levels AngII Ang1-7 ELISA.miR-34a negatively...
CD147/basigin (Bsg), a transmembrane glycoprotein, activates matrix metalloproteinases and promotes inflammation.The aim of this study is to explore the clinical significance CD147 in pathogenesis inflammatory bowel disease (IBD).In addition monocytes, analysis showed that there no obtained leucocyte, neutrophil, eosinophil, basophil, erythrocyte between IBD controls. Immunohistochemistry was increased intestinal tissue patients with active compared control group. What more, involved barrier...
To investigate the impact of IGJ on proliferation, inflammation, and motility rheumatoid arthritis (RA) fibroblast-like synoviocytes elucidate underlying mechanism.
<abstract abstract-type="Summary"> <sec> <b>What is already known about this topic?</b> Diarrhea represents a substantial public health issue, contributing globally to high number of pediatric medical consultations, hospital admissions, and mortality rates. </sec><sec> added by report?</b> An increase in diarrheal frequency serves as critical benchmark for evaluating severity. The predominant pathogens associated with diarrhea are rotavirus norovirus, co-infections exerting notable...
Cancer is always the greatest threat to human health. In this work, a split-ring resonator (SRR)-based sensor was simulated for label-free detection on biomarkers in microwave. The model of biosensor by Computer Simulation Technology 2017 (CST2017) and some influences feature parameters resonance frequency Q-factor were also discussed. From simulation results, our work showed ultrahigh sensitivity under different permittivities exhibited trend better performance when it works higher...